Soochow University

Carnosol Accelerates Pressure Ulcer Healing via Keap1-Nrf2/HO-1-Mediated Mitochondrial Quality Control

Abstract Pressure ulcer pathogenesis involves ischemia-reperfusion-induced oxidative stress and mitochondrial dysfunction. Carnosol, a rosemary-derived diterpene with antioxidant properties, was investigated for its therapeutic potential in tissue repair. Carnosol pretreatment pr...

Ambient‐Pressure Polyolefin Upcycling With Earth‐Abundant Catalyst

ABSTRACT Polyolefin hydrogenolysis offers a promising route for the upcycling of plastic waste, yet is hindered by the high cost of noble‐metal catalysts and the safety concerns of high‐pressure H 2 . Current systems typically rely on Ru or Pt catalysts to mediate key elementary...

Chronic kidney disease due to hypertension in China, Japan, and the Republic of Korea: trends from the Global Burden of Disease Study 1990–2023

Abstract Objective To evaluate the burden and temporal trends of chronic kidney disease (CKD) attributable to hypertension in China, Japan, and the Republic of Korea from 1990 to 2023 using Global Burden of Disease (GBD) 2023 data. Methods Age-standardized incidence, mortality, a...

SDF4 is a potential biomarker for diagnosis and severity assessment in patients with systemic lupus erythematosus

Abstract Background The implementation of refined management of systemic lupus erythematosus (SLE) poses a considerable challenge in clinical practice. In this study, we evaluated serum stromal cell-derived factor 4 (SDF4) as potential biomarkers for SLE diagnosis, disease severi...

Efficacy and Safety of the First Adalimumab Biosimilar in Chinese Children with Severe Plaque Psoriasis: The PISCES Study, a Multicenter Prospective Study

Adalimumab, a monoclonal antibody targeting tumor necrosis factor-alpha, has been approved for the treatment of severe plaque psoriasis in children aged 4 years and older. Data on its use in the clinical management of pediatric psoriasis in China remains limited. This study is th...

Intermolecular Formal [2 + 1] Cycloaddition with Sulfoxonium Ylides via Energy Transfer Photocatalysis

Abstract Among the recognized methods to build cyclopropanes via photocatalytic [2 + 1] cycloaddition, the strategy of activation of the C1 synthon is exclusively dominant, while the photocatalytic activation of C2 synthon coupled with appropriate C1 synthon remains overlooked. H...

Nintedanib in the prevention of radiation-induced lung injury in patients with unresectable stage II-III NSCLC: A protocol for a randomized, multicenter, control group study

Background Radiation-induced lung injury (RILI) is a common and dose-limiting complication in patients with non-small cell lung cancer (NSCLC) receiving radiotherapy, especially in combination with chemotherapy and/or immunotherapy. RILI encompasses acute radiation pneumonitis (R...

A fitness advantage from the pLVPK plasmid fuels the global spread of a carbapenem-resistant hypervirulent Klebsiella pneumoniae high-risk clone: ST11-KL64

BACKGROUND: The global emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP), particularly the ST11-KL64 subclone acquiring pLVPK-like virulence plasmids, represents a critical public health threat. This study investigates the epidemiological dominance a...

Flexible Photochromic Synaptic Devices for UV Perception and Spatiotemporal Encoding

ABSTRACT Flexible synaptic devices with short‐term optical dynamics offer promising building blocks for low‐power and visualized neuromorphic perception, yet introducing time‐dependent weight update and visual readout remains highly challenging. Herein, we establish a universal s...

Genomic and transcriptomic landscape of overweight Chinese breast cancer reveals NOTCH2 mutation–mediated endocrine resistance and therapeutic strategies

Abstract Background Obesity (OB) and overweight (OW) are common in patients with breast cancer and are associated with inferior outcomes, yet their impact on tumor molecular architecture remains incompletely understood. This study aimed to define the genomic and transcriptomic fe...

24-hour movement behaviour patterns differ across depressive symptom trajectories in community-dwelling older adults: a group-based trajectory model and compositional data analysis

Depressive symptoms in older adults change over time and do not follow a single uniform pattern. Whether 24-hour movement behaviour composition differs across depressive symptom trajectories remains unclear. This longitudinal secondary analysis used data from the Survey of Health...

Supersolvable closures of finitely generated subgroups of the free group

Abstract We prove that the pro-(finite supersolvable) closure of a finitely generated subgroup of the free group is finitely generated. This extends similar results for pro-𝑝 closures proved by Ribes–Zalesskii and pro-(finite nilpotent) closures proved by Margolis–Sapir–Weil.

Exploring baryon semileptonic decays through polarization and entanglement

Abstract The unitarity of the Cabibbo–Kobayashi–Maskawa (CKM) matrix is a cornerstone of the standard model (SM). Precise tests of this unitarity require independent determinations of its elements, such as | V us |, which governs the transition between strange and up quarks. Curr...

Uncorrelated Semi-paired Subspace Learning

Multi-view datasets are increasingly collected in many real-world applica tions, and existing multi-view learning methods byleveraging therelation information across multiple views have gained great successes comparing to conventional single view learning methods. However, most o...

WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M 6 A‐Mediated Regulation of CSF1R Signaling in Estrogen‐Deficient Osteoporosis

ABSTRACT Osteoporosis, characterized by imbalanced bone homeostasis, is driven by excessive osteoclast‐mediated bone resorption, yet the epitranscriptomic regulation via m 6 A modification remains unclear. Here, we identify WTAP, a component of the m 6 A methyltransferase complex...

The role of lipid metabolism in immune thrombocytopenia: new perspectives from immune inflammation and thrombopoiesis

Abstract Background Primary immune thrombocytopenia (ITP) is an autoimmune condition defined by increased immune-driven platelet destruction and inadequate platelet generation. Emerging research highlights that global alterations in lipid metabolism are closely associated with im...

Carbon dots in photocatalytic water splitting and related proton/electron‐coupled reactions: Multiscale regulation of charge dynamics and interfacial processes

Abstract Photocatalytic water splitting provides a representative platform for understanding the relationship between photogenerated charge utilization and interfacial catalytic conversion. The overall efficiency of this process is governed by the coupling between ultrafast photo...

Differential nodal topology in resting-state networks as a potential imaging marker for adolescent bipolar and depressive disorders

Overlapping clinical features and the absence of objective diagnostic markers frequently lead to the misdiagnosis of adolescent bipolar disorder (BD) as major depressive disorder (MDD). However, direct comparisons of functional brain network topology between adolescents with MDD...

Prediction models for intraoperative blood loss in spine surgery: a systematic review and methodological appraisal

Prediction models may support perioperative blood management in spine surgery, but their credibility depends on outcome definition, prediction time, calibration, validation, and transparent reporting rather than discrimination alone. We searched nine databases from inception to A...

Conformation‐Locking in Thiazole‐Rich Mixed‐Linkage Covalent Organic Frameworks for Spontaneous Exciton Dissociation and Efficient Photocatalysis

ABSTRACT The formidable exciton effect inherent in organic semiconductors fundamentally restricts free charge carrier generation, thereby impeding photocatalytic redox efficiency. Facilitating spontaneous exciton dissociation and lowering exciton binding energy are essential for...