Soochow University

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...

Effect of Nickel Addition on Corrosion Behavior of Laser–Arc Hybrid Welded Al-Mg-Si-Cu Alloy Joints

The corrosion performance of Al-Mg-Si-Cu laser–arc hybrid welded joints modified by 1.8 wt.% Ni remains poorly clarified. In this study, the corrosion behavior was examined via electrochemical measurements combined with SEM, EDS, and SKPFM. Nickel alloying increased the corrosion...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Macrophage RIPK3 facilitates TRAF6 K63-linked ubiquitination and exacerbates acute pancreatitis

Abstract Acute pancreatitis (AP) is characterized by acinar cell injury and death triggered by multiple etiologies, culminating in local and systemic inflammatory responses. Current therapeutic options for AP, particularly severe AP, remain limited. While RIPK3-mediated necroptos...

Validation of [89Zr]Zr-oxine labelling and PET/CT imaging for tracking mesenchymal stem cells in mice and patients with perianal fistula

Allogeneic umbilical cord-derived mesenchymal stem cells (TH-SC01) hold promise for treating perianal fistulas (pf) in Crohn’s disease (pfCD); however, like other live-cell products, their in vivo behaviour remains unclear. Zirconium-89 ([ 89 Zr]Zr)-oxine positron emission tomogr...

Spin-quenching cobalt center for efficient ammonia synthesis derived from oxide mixology

The spin polarization plays a critical role in heterogeneous catalysis by influencing the properties of active sites and thereby altering catalytic performance. However, precise construction of active sites with well-tuned spin states remains challenging. Here we demonstrate to m...

Situational characteristics of lower limb muscle cramps in male semi-elite football players: a video-based descriptive case series

Lower limb muscle cramps are a common yet under-researched acute condition in semi-elite football, and empirical evidence regarding their situational characteristics remains scarce. This study aimed to systematically explore the temporal-spatial situational characteristics, short...

Dual Multiplexing of Wavelength and Orbital Angular Momentum for Expanded Information Capacity With a Single Freeform Micro‐Structured Element

ABSTRACT Optical multiplexing is an important method for expanding information capacity. Here, we propose and experimentally demonstrate dual multiplexing of wavelength and orbital angular momentum (OAM) for expanded information capacity with a single freeform micro‐structured el...

Regulating Uniform Zinc Deposition via Covalently Tethered Imidazolium Cations in Polyacrylamide Hydrogel Electrolytes for Stable Aqueous Zinc Batteries

ABSTRACT Aqueous zinc‐ion batteries (AZIBs) are promising candidates for next‐generation energy storage due to their intrinsic safety and low cost. However, the uncontrollable zinc dendrite growth and interfacial side reactions limit their cycling stability and practical applicat...

Synthesis, Structure, and Photothermal Conversion of a Bowl‐Shaped Nanographene Containing Fused 5‐/7‐Ring Pairs

ABSTRACT Incorporation of non‐hexagonal topologies into bowl‐shaped nanographenes offers opportunities for tailoring their electronic properties and supramolecular behavior, however synthesis of such curved systems remains challenging. Herein, we report the facile synthesis of a...

Synthesis, Structure, and Photothermal Conversion of a Bowl‐Shaped Nanographene Containing Fused 5‐/7‐Ring Pairs

ABSTRACT Incorporation of non‐hexagonal topologies into bowl‐shaped nanographenes offers opportunities for tailoring their electronic properties and supramolecular behavior, however synthesis of such curved systems remains challenging. Herein, we report the facile synthesis of a...

Subcutaneous Belimumab Demonstrates Consistent Steady-State Pharmacokinetics and is Well Tolerated in Paediatric Patients with SLE in China: An Open-Label Study

This study assessed pharmacokinetics and safety of subcutaneous (SC) belimumab in Chinese paediatric patients with systemic lupus erythematosus (cSLE) who previously received intravenous (IV) belimumab; only the IV form is approved for cSLE in China. This single-arm, open-label,...

Emerging Near‐Infrared Optical Materials Based on Supramolecular Charge Transfer Complexes

ABSTRACT Organic charge transfer complexes (CTCs), formed by donor–acceptor (D–A) coassembly, have emerged as a supramolecular platform for programmable near‐infrared (NIR) optics. In their D–A assemblies, packing‐dependent electronic coupling and delocalization generate tunable...

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

ABSTRACT Ferroptosis contributes to Parkinson's disease (PD) through interconnected processes including iron dysregulation, oxidative stress, and mitochondrial dysfunction, yet current therapies targeting single pathways remain insufficient. Herein, we developed gallium–quercetin...

Interim Efficacy Analysis of Different Anticoagulation Regimens in Patients with Long-term Implantation of Inferior Vena Cava Filter

Abstract: To analyze the interim efficacy of different anticoagulation regimens for patients with long-term inferior vena cava filter (IVCF) implantation. From August 2021 to August 2024, a retrospective analysis of patients who underwent long-term IVCF implantation in multiple c...

MBNL1 hijacks a structured single-stranded distal DNA element to sustain FLT3 expression in KMT2A-rearranged leukemias

The molecular mechanisms by which KMT2A-rearranged (KMT2A-r) leukemias maintain the oncogenic FLT3 expression remain largely unclear, limiting therapeutic opportunities. Here, we identify the RNA binding protein MBNL1 as an unexpected positive regulator of FLT3 by DepMap dataset...

An ensemble learning framework for protein stability prediction with enhanced recognition of stabilizing mutations

Accurately predicting mutation-induced protein stability changes remains a central challenge in structural bioinformatics. Existing methods exhibit a strong bias toward destabilizing mutations, leading to limited performance for stabilizing mutations and constraining their utilit...

An ELISA‐Inspired Self‐Propagating Click‐Fluoresce‐and‐Release Assay for the Ultrasensitive Detection of CD13 in Lung Cancer Patient Plasma

ABSTRACT Reaction‐based fluorescent probes often suffer from limited sensitivity in biomarker detection due to slow reaction kinetics and inherent stoichiometric constraints. Inspired by the decoupling of capture and detection in the enzyme‐linked immunosorbent assay (ELISA), we...

Comprehensive genomic characterization of extraintestinal pathogenic Escherichia coli isolated from neonates: multiple center insights into virulence, resistance, and transmission dynamics

Neonatal extraintestinal pathogenic Escherichia coli (ExPEC), which can cause severe long-term sequelae by systemic infections, is gradually becoming the primary pathogen threatening neonatal health. The lack of large-scale genomic epidemiological investigation hinders further un...

An ELISA‐Inspired Self‐Propagating Click‐Fluoresce‐and‐Release Assay for the Ultrasensitive Detection of CD13 in Lung Cancer Patient Plasma

ABSTRACT Reaction‐based fluorescent probes often suffer from limited sensitivity in biomarker detection due to slow reaction kinetics and inherent stoichiometric constraints. Inspired by the decoupling of capture and detection in the enzyme‐linked immunosorbent assay (ELISA), we...