Soochow University

MBNL1 hijacks a structured single-stranded distal DNA element to sustain FLT3 expression in KMT2A-rearranged leukemias

The molecular mechanisms by which KMT2A-rearranged (KMT2A-r) leukemias maintain the oncogenic FLT3 expression remain largely unclear, limiting therapeutic opportunities. Here, we identify the RNA binding protein MBNL1 as an unexpected positive regulator of FLT3 by DepMap dataset...

Interim Efficacy Analysis of Different Anticoagulation Regimens in Patients with Long-term Implantation of Inferior Vena Cava Filter

Abstract: To analyze the interim efficacy of different anticoagulation regimens for patients with long-term inferior vena cava filter (IVCF) implantation. From August 2021 to August 2024, a retrospective analysis of patients who underwent long-term IVCF implantation in multiple c...

Comprehensive genomic characterization of extraintestinal pathogenic Escherichia coli isolated from neonates: multiple center insights into virulence, resistance, and transmission dynamics

Neonatal extraintestinal pathogenic Escherichia coli (ExPEC), which can cause severe long-term sequelae by systemic infections, is gradually becoming the primary pathogen threatening neonatal health. The lack of large-scale genomic epidemiological investigation hinders further un...

An ELISA‐Inspired Self‐Propagating Click‐Fluoresce‐and‐Release Assay for the Ultrasensitive Detection of CD13 in Lung Cancer Patient Plasma

ABSTRACT Reaction‐based fluorescent probes often suffer from limited sensitivity in biomarker detection due to slow reaction kinetics and inherent stoichiometric constraints. Inspired by the decoupling of capture and detection in the enzyme‐linked immunosorbent assay (ELISA), we...

An ELISA‐Inspired Self‐Propagating Click‐Fluoresce‐and‐Release Assay for the Ultrasensitive Detection of CD13 in Lung Cancer Patient Plasma

ABSTRACT Reaction‐based fluorescent probes often suffer from limited sensitivity in biomarker detection due to slow reaction kinetics and inherent stoichiometric constraints. Inspired by the decoupling of capture and detection in the enzyme‐linked immunosorbent assay (ELISA), we...

An ensemble learning framework for protein stability prediction with enhanced recognition of stabilizing mutations

Accurately predicting mutation-induced protein stability changes remains a central challenge in structural bioinformatics. Existing methods exhibit a strong bias toward destabilizing mutations, leading to limited performance for stabilizing mutations and constraining their utilit...

Artificial intelligence empowers full-stack histopathological diagnosis and prognosis of renal cell tumor: a multi-center study with external validation

BACKGROUND: The rapid advancement of digital pathology has opened unprecedented opportunities for intelligent diagnosis in renal cell tumor. However, there remains a significant gap in the availability of reliable deep learning models capable of comprehensive kidney cancer detect...

A molecular glue induces aberrant STING oligomerization and inhibits autoinflammatory diseases

Dysregulated activation of the stimulator of interferon genes (STING) pathway underlies various inflammatory and autoimmune pathologies. Since STING oligomerization is fundamental to its biological function, targeted modulation of this polymerization process presents a promising...

Multi‐Level Crosslinked Structure Fiber Composite Membrane With Multifunctional Properties: High Strength, Flexibility and EMI Shielding

Rational structural design remains a key challenge in developing multifunctional membranes with high strength, flexibility, and excellent electromagnetic interference shielding effectiveness (EMI SE). Herein, poly(vinyl alcohol-co-ethylene) (PVA-co-PE) nanofibers and UHMWPE fiber...

Dynamical arrest in colloidal monolayers induced by energy landscape

Using video microscopy, we experimentally investigate how a periodic potential landscape influences the dynamics of colloidal monolayers. The potential is generated by a layer of densely packed particles immobilized on the substrate, creating a spatially periodic gravitational fi...

Prediction of Mechanical Properties of Bolted Connections in CFST Column–Steel Beam Assemblies Based on Improved Particle Swarm Optimization and Deep Neural Networks

Predicting the mechanical properties of bolted connection nodes in prefabricated Concrete-Filled Steel Tube (CFST) column–steel beam assemblies remains challenging due to complex nonlinear relationships, high degrees of parameter coupling, and limited generalization capabilities...

Triboron Multiresonant Emitter With Zigzag B/N Alignment Enables Near‐Degenerate Singlet–Triplet States for High‐Performance Non‐Sensitized OLEDs With Mild Roll‐Off

ABSTRACT Boron/nitrogen‐embedded polycyclic frameworks are attractive emitters in organic light‐emitting diodes (OLEDs) because they combine narrowband emission with thermally activated delayed fluorescence. Linear extension of multiresonant frameworks with zigzag boron/nitrogen...

OMVs of Pseudomonas aeruginosa extracted from chronic suppurative otitis media trigger ototoxicity: possible relation to activation of NLRP3 inflammasome

Abstract Background Chronic suppurative otitis media (CSOM) can lead to sensorineural hearing loss (SNHL), but the underlying mechanisms remain incompletely understood. This study aimed to investigate whether the outer membrane vesicles (OMVs) from Pseudomonas aeruginosa ( P.aeru...

CTC-AttnNet: development and validation of an attention-based neural network for staging gastrointestinal malignancies

To develop and validate a noninvasive model for classifying T stage in gastrointestinal malignancies using circulating tumor cells (CTCs) and serum tumor markers and to compare the predictive value of CTCs with that of conventional tumor markers. This retrospective study included...

Adaptive intrathecal nanorobotics in mice and nonhuman primates for navigated CNS therapy

Intrathecal delivery for central nervous system (CNS) therapy lacks spatiotemporal control due to spinal canal anatomical constraints, especially at human scale. We developed an adaptive magnetic nanorobotic platform enabling multimode swarm mobility for in vivo spinal canal navi...

Macrophage senescence and senescence-like states in senile osteoporosis: cellular cross-talk and therapeutic perspectives

Senile osteoporosis (SOP) is an age-related metabolic bone disease characterized by reduced bone quality and increased fracture risk, closely associated with immune senescence. Among immune components in the bone marrow niche, macrophages undergo age-associated phenotypic and fun...

Non-elastic membrane dual-actuation liquid lens for continuous focus and zoom

Miniaturization is crucial for technological advancement and innovation. Simplifying systems, reducing device size, and integrating multiple functions remain limiting factors for the miniaturization of optical imaging systems. Liquid lenses offer compact structure, fast response,...