Soochow University

Laboratory aspirin resistance and the incidence of preeclampsia under prophylactic low-dose aspirin therapy: a systematic review and meta-analysis

A subset of pregnant women treated with prophylactic low-dose aspirin (LDA) still develop preeclampsia (PE), a severe pregnancy-related complication. It is hypothesized that laboratory aspirin resistance (LAR), which may undermine the preventive efficacy of LDA, is associated wit...

Drosha in mesangial cells regulates glomerular capillary tufts formation through drosha/ribosome/Gata3 axis

Abstract Drosha is a critical regulator of kidney development; its loss or mutation, identified in a subsets of Wilms tumor (WT), a pediatric kidney cancer, leads to nephric cap mesenchyme developmental defects. Here, we investigated the role of Drosha in mesangial cells and its...

Cholesteric Liquid Crystal Elastomer-Based Single-Ion Conductor for Advanced Quasi-Solid Electrolyte Membranes

Self-assembled liquid crystal polymer networks build directional transport channels via molecular alignment, enabling efficient and ordered lithium-ion migration, while single-ion conducting polymer electrolytes improve lithium-ion transference number by covalently anchoring anio...

Prognostic value of systemic immune‐inflammation index and systemic inflammation response index with maternal gestational diabetes mellitus: A systematic review and meta‐analysis

OBJECTIVE: Mounting evidence indicates that the systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) might be associated with the risk of gestational diabetes mellitus (GDM). However, existing findings remain inconclusive. This systematic revie...

Association Between Vitamin D and Muscle Mass and Function in Children and Adolescents

OBJECTIVE: This study aimed to investigate the association between vitamin D and muscle health in children and adolescents. DESIGN: A cross-sectional analysis was performed using data from 2,775 participants aged 8-17 years in NHANES 2011-2014. Muscle mass was evaluated through w...

Gut microbiota-derived indoleacrylic acid ameliorates rheumatoid arthritis by preventing necroptosis of fibroblast-like synoviocytes and regulating macrophage polarization

Rheumatoid arthritis (RA) is associated with gut metabolite dysfunction, but the contribution of tryptophan-derived metabolites to RA remains fully uncharacterized. Here, we investigated the role of the gut microbiota-derived tryptophan metabolite indoleacrylic acid (IA) in exper...

Synergistic Molecular Modulation via Coordination and Hydrogen Bonding for Efficient Perovskite and Tandem Solar Cells

ABSTRACT Molecular additives offer a powerful route to control crystallization kinetics and homogenize component distribution in perovskite semiconductors. However, additives that integrate Pb‐related coordination and hydrogen‐bonding functionalities within a single molecular fra...

Ultra-fast battery health estimation from random 100 mV charging fragments using conditional generative diffusion

State-of-health (SOH) estimation is essential for lithium-ion battery management. However, real-world disruptions often result in fragmented battery data, making reliable SOH estimation challenging. Generative artificial intelligence offers a promising paradigm to address these l...

A Comprehensive Assessment Framework for the Sustainable Ecological Carrying Capacity of Chinese Cities Based on Time-Series Uncertainty and Interval-Valued Fermatean Fuzzy Sets

The assessment of sustainable ecological carrying capacity (SECC) serves as a crucial scientific foundation for supporting high-quality urbanization, advancing ecological civilization, and achieving the strategic goals of the “Dual Carbon” initiative. However, existing assessment...

Astaxanthin supplementation and cardiometabolic risk factors in overweight and obese adults: a GRADE-assessed systematic review and meta-analysis

Astaxanthin, a marine-derived carotenoid, has shown antioxidant and anti-inflammatory properties in studies. However, its effects on cardiometabolic risk factors in overweight and obese populations remain inconclusive. Therefore, this systematic review and meta-analysis aimed to...

The influence of position effects of repeated items in non-strict sequences on the distance effect and reverse distance effect

This study systematically investigated the sequential processing mechanisms in non-strict sequences (sequences containing repeated items) through four experiments, examining how sequence length, item repetition position, and material type modulate distance effect patterns. Experi...

An Integrated dual-mode NIR Screening Device Forged by Spectrally Engineered Perovskite pc-LEDs

Abstract Translating advanced luminescent materials into field-deployable screening tools remains a core challenge, demanding synergy between advanced optical materials and device engineering. Here, we demonstrate a portable dual-mode near-infrared semi-quantitative screening dev...

Association Between Cognitively Stimulating Activities and Cognitive Function in Older Adults Living in Residential Care Homes

OBJECTIVE: To examine the relationship between cognitively stimulating activities and cognitive function among older adults in residential care homes. METHODS: A convenience sampling method was used to recruit older adults from three residential care homes in East China. Data wer...

Vitality Measurement and Smart Governance Strategies for Marginal Communities in Suzhou: A Study Based on the Vision of an International and Modern People-Oriented City

Accelerating the construction of an international, modern, and people-oriented city, Suzhou often faces bottlenecks in its peripheral communities. These open spaces suffer from rapid vitality decline, extensive governance, and weak resilience, which directly hinder residents’ dai...

Early oseltamivir initiation and influenza outcomes in kidney transplant recipients: a multicenter real-world study

Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Sirtuin 4 knockout exacerbates cardiac injury in septic cardiomyopathy via activating the MAPK-JNK pathway

Septic cardiomyopathy (SCM) significantly contributes to mortality among septic patients, and its mechanism is closely related to abnormal inflammatory responses. Previous studies revealed the essential role of the Sirtuin4 gene in cardiomyocyte and myocardial function; however,...

PD-L1+ exosomes as biomarkers and therapeutic targets in multiple myeloma: implications for CAR-T efficacy and combination immunotherapy

Although chimeric antigen receptor T-cell (CAR-T) therapy has reshaped the treatment landscape for relapsed/refractory multiple myeloma (RRMM), durable remission remains challenging. T-cell dysfunction and exhaustion are key obstacles to long-term efficacy. Programmed death-ligan...

Validation of the “purfling sign” for differentiating primary central nervous system lymphoma from high-grade glioma: a retrospective multicenter cohort study

Abstract Background The study aimed to evaluate whether the imaging marker “purfling sign” can reliably distinguish primary central nervous system lymphoma (PCNSL) from high-grade glioma and systematically assess its diagnostic performance, differential utility and clinical value...

An Enhanced Fault-Tolerant Scheme for Arm-Multiplexing Modular Multilevel Converters

The arm-multiplexing modular multilevel converter (AM-MMC) is a new compact MMC topology that is especially promising for offshore high-voltage direct current transmission systems. However, the reliable operation of AM-MMCs suffers from submodule (SM) faults. The fault-tolerant s...