Soochow University

Early oseltamivir initiation and influenza outcomes in kidney transplant recipients: a multicenter real-world study

Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

PD-L1+ exosomes as biomarkers and therapeutic targets in multiple myeloma: implications for CAR-T efficacy and combination immunotherapy

Although chimeric antigen receptor T-cell (CAR-T) therapy has reshaped the treatment landscape for relapsed/refractory multiple myeloma (RRMM), durable remission remains challenging. T-cell dysfunction and exhaustion are key obstacles to long-term efficacy. Programmed death-ligan...

Sirtuin 4 knockout exacerbates cardiac injury in septic cardiomyopathy via activating the MAPK-JNK pathway

Septic cardiomyopathy (SCM) significantly contributes to mortality among septic patients, and its mechanism is closely related to abnormal inflammatory responses. Previous studies revealed the essential role of the Sirtuin4 gene in cardiomyocyte and myocardial function; however,...

Spin-quenching cobalt center for efficient ammonia synthesis derived from oxide mixology

The spin polarization plays a critical role in heterogeneous catalysis by influencing the properties of active sites and thereby altering catalytic performance. However, precise construction of active sites with well-tuned spin states remains challenging. Here we demonstrate to m...

Situational characteristics of lower limb muscle cramps in male semi-elite football players: a video-based descriptive case series

Lower limb muscle cramps are a common yet under-researched acute condition in semi-elite football, and empirical evidence regarding their situational characteristics remains scarce. This study aimed to systematically explore the temporal-spatial situational characteristics, short...

An Enhanced Fault-Tolerant Scheme for Arm-Multiplexing Modular Multilevel Converters

The arm-multiplexing modular multilevel converter (AM-MMC) is a new compact MMC topology that is especially promising for offshore high-voltage direct current transmission systems. However, the reliable operation of AM-MMCs suffers from submodule (SM) faults. The fault-tolerant s...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Effect of Nickel Addition on Corrosion Behavior of Laser–Arc Hybrid Welded Al-Mg-Si-Cu Alloy Joints

The corrosion performance of Al-Mg-Si-Cu laser–arc hybrid welded joints modified by 1.8 wt.% Ni remains poorly clarified. In this study, the corrosion behavior was examined via electrochemical measurements combined with SEM, EDS, and SKPFM. Nickel alloying increased the corrosion...

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...

Validation of the “purfling sign” for differentiating primary central nervous system lymphoma from high-grade glioma: a retrospective multicenter cohort study

Abstract Background The study aimed to evaluate whether the imaging marker “purfling sign” can reliably distinguish primary central nervous system lymphoma (PCNSL) from high-grade glioma and systematically assess its diagnostic performance, differential utility and clinical value...

Macrophage RIPK3 facilitates TRAF6 K63-linked ubiquitination and exacerbates acute pancreatitis

Abstract Acute pancreatitis (AP) is characterized by acinar cell injury and death triggered by multiple etiologies, culminating in local and systemic inflammatory responses. Current therapeutic options for AP, particularly severe AP, remain limited. While RIPK3-mediated necroptos...

Validation of [89Zr]Zr-oxine labelling and PET/CT imaging for tracking mesenchymal stem cells in mice and patients with perianal fistula

Allogeneic umbilical cord-derived mesenchymal stem cells (TH-SC01) hold promise for treating perianal fistulas (pf) in Crohn’s disease (pfCD); however, like other live-cell products, their in vivo behaviour remains unclear. Zirconium-89 ([ 89 Zr]Zr)-oxine positron emission tomogr...

Regulating Uniform Zinc Deposition via Covalently Tethered Imidazolium Cations in Polyacrylamide Hydrogel Electrolytes for Stable Aqueous Zinc Batteries

ABSTRACT Aqueous zinc‐ion batteries (AZIBs) are promising candidates for next‐generation energy storage due to their intrinsic safety and low cost. However, the uncontrollable zinc dendrite growth and interfacial side reactions limit their cycling stability and practical applicat...

Synthesis, Structure, and Photothermal Conversion of a Bowl‐Shaped Nanographene Containing Fused 5‐/7‐Ring Pairs

ABSTRACT Incorporation of non‐hexagonal topologies into bowl‐shaped nanographenes offers opportunities for tailoring their electronic properties and supramolecular behavior, however synthesis of such curved systems remains challenging. Herein, we report the facile synthesis of a...

Synthesis, Structure, and Photothermal Conversion of a Bowl‐Shaped Nanographene Containing Fused 5‐/7‐Ring Pairs

ABSTRACT Incorporation of non‐hexagonal topologies into bowl‐shaped nanographenes offers opportunities for tailoring their electronic properties and supramolecular behavior, however synthesis of such curved systems remains challenging. Herein, we report the facile synthesis of a...

Emerging Near‐Infrared Optical Materials Based on Supramolecular Charge Transfer Complexes

ABSTRACT Organic charge transfer complexes (CTCs), formed by donor–acceptor (D–A) coassembly, have emerged as a supramolecular platform for programmable near‐infrared (NIR) optics. In their D–A assemblies, packing‐dependent electronic coupling and delocalization generate tunable...

Dual Multiplexing of Wavelength and Orbital Angular Momentum for Expanded Information Capacity With a Single Freeform Micro‐Structured Element

ABSTRACT Optical multiplexing is an important method for expanding information capacity. Here, we propose and experimentally demonstrate dual multiplexing of wavelength and orbital angular momentum (OAM) for expanded information capacity with a single freeform micro‐structured el...

Subcutaneous Belimumab Demonstrates Consistent Steady-State Pharmacokinetics and is Well Tolerated in Paediatric Patients with SLE in China: An Open-Label Study

This study assessed pharmacokinetics and safety of subcutaneous (SC) belimumab in Chinese paediatric patients with systemic lupus erythematosus (cSLE) who previously received intravenous (IV) belimumab; only the IV form is approved for cSLE in China. This single-arm, open-label,...

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

ABSTRACT Ferroptosis contributes to Parkinson's disease (PD) through interconnected processes including iron dysregulation, oxidative stress, and mitochondrial dysfunction, yet current therapies targeting single pathways remain insufficient. Herein, we developed gallium–quercetin...