Soochow University

Therapeutic-scale CAR-NK microrobots with programmable swarm navigation for targeted solid tumor therapy

An urgent requirement in chimeric antigen receptor (CAR) immune cell therapy [e.g., CAR–natural killer (NK) cells] for solid tumors is to engineer the cells for precise tumor targeting. Meanwhile, medical microrobots can be navigated toward specific target sites using external ma...

Cholesteric liquid crystal polymer network patterns prepared by inkjet printing of inks with a fluorinated diacrylate liquid crystal

Diacrylate liquid crystals have been widely used in fabricating cholesteric liquid crystal polymer network (CLCN) patterns through various methods. In this work, a series of laterally fluorinated diacrylate liquid crystals were synthesised using fluorinated p-hydroxybenzoic acids...

High mobility narrowband-emissive organic semiconductors

This work proposes a synergistic control strategy of molecular packing and transition dipole moment orientation for achieving high mobility narrowband-emissive organic semiconductors.

Radon Exposure: A Comprehensive Review of the Health Risks and Therapeutic Potentials

Radon, a naturally occurring radioactive gas, is classified as a Group 1 carcinogen by the World Health Organization (WHO) and remains a significant environmental health hazard. Traditionally linked to lung cancer, radon exposure is the second leading cause of lung cancer worldwi...

A defect and multi-physics informed neural network for fatigue life prediction in friction stir welded additive manufacturing AlSi7Mg

Additively manufactured aluminium alloys joined by friction stir welding exhibit great potential for large-scale structural applications, yet their fatigue life prediction remains challenging due to the complex influence of internal defects and process-induced microstructural het...

Energy retrofit of historic buildings under wall mould growth constraints: A case study in Suzhou, China

In the hot, humid climate of southern China, energy retrofit of historic buildings is constrained by poor envelope thermal performance and a high mould risk. Although internal insulation can reduce energy demand, it alters wall hygrothermal conditions and may increase the risk of...

Behaviour-aware physics-informed trajectory prediction for freeway on-ramp merging vehicles

Freeway merging areas involve intense interactions and non-stationary traffic dynamics, making accurate on-ramp trajectory prediction essential for safe and cooperative driving. However, existing deep learning methods often overfit and fail to maintain physical consistency under...

Dialkylation of Vinyl Arenes under Cobalt Catalysis

Abstract Herein, a directing group and ligand-free cobalt-catalyzed alkene dialkylation with various alkyl halides and alkylzinc pivalates is reported. This method is distinguished by its broad scope, synthetic simplicity, and excellent regio- and chemoselectivities, thus providi...

Clinical Outcome Differences in Asia Versus Non-Asia Intracerebral Hemorrhage: IPD Analysis From BP-Lowering Clinical Trials

BACKGROUND: Evidence of regional differences in clinical outcomes after intracerebral hemorrhage (ICH) is still scarce. We quantified differential outcomes and response to early intensive blood pressure lowering treatment by region in the Blood pressure in Acute Stroke Collaborat...

Uniqueness of Markov numbers with a large prime-power divisor

The Frobenius uniqueness conjecture asserts that the largest entry of a positive integral solution of a^2 + b^2 + m^2 = 3abm determines the other two entries up to order. We prove that a Markov number m > 2 is unique if it has an odd prime-power divisor q satisfying ε q > 3^{-6/4...

Group Theory-Guided Orbital Symmetry Engineering of cis -Quinacridone: From Symmetry-Forbidden to Dipole-Allowed Transitions for Efficient Narrowband Emissions

Abstract Although group theory is widely used to analyze symmetry and electronic transition selection rules in condensed matter physics and coordination chemistry, its use as a predictive design tool for organic light-emitting diodes (OLEDs) remains largely unexplored. This is pa...

Time-Dependent Prognostic Value of the sCD25-to-Ferritin Ratio in Chronic Active Epstein–Barr Virus-Associated Hemophagocytic Lymphohistiocytosis

INTRODUCTION: Chronic active Epstein-Barr virus infection (CAEBV) is an EBV-positive T/NK-cell lymphoproliferative disease characterized by persistent EBV infection in T or NK cells. CAEBV-HLH refers to hemophagocytic lymphohistiocytosis secondary to CAEBV. As important markers o...

Molecular subclassification of MGMT-unmethylated high-grade glioma identifies divergent tumor states and therapeutic vulnerabilities

MGMT-unmethylated high-grade glioma (HGG) is associated with poor response to temozolomide and limited therapeutic options. However, substantial molecular heterogeneity exists within this clinically defined subgroup and remains insufficiently characterized. Transcriptomic and cli...

Micro/Nanostructured Materials and Microfluidic Diagnostic Platforms Enable Multimodal Detection of Circulating Tumor Cells

ABSTRACT Circulating tumor cells (CTCs), as pivotal targets in liquid biopsy, offer dynamic, multidimensional insights into tumor heterogeneity and metastatic progression. However, their extreme rarity, pronounced heterogeneity, and the complexity of the blood microenvironment se...

U-shaped association of platelet-to-lymphocyte ratio with all-cause and cardiovascular mortality in hypertension: mediating role of renal dysfunction in a nationwide cohort (NHANES 2005–2018)

To evaluate the association between the platelet-to-lymphocyte ratio (PLR) and all-cause and cardiovascular mortality among adults with hypertension in the National Health and Nutrition Examination Survey (NHANES). We conducted a prospective cohort analysis using NHANES 2005–2018...

Two‐Dimensional Framework Materials as Building Blocks for Next‐Generation Intelligent Biointerfaces

ABSTRACT The convergence of neural interfaces, wearable bioelectronics, and human‐machine interaction is driving intelligent biointerfaces capable of sensing and responding to neural, physiological, and biomechanical signals. Realizing this vision demands a substantial advance in...

Plasma Glutamine and Glutamate in Relation to Clinical Outcomes After Ischemic Stroke: A Multicenter Prospective Study

Background Glutamine (Gln) and glutamate (Glu) have been suggested to play a pivotal role in neuronal homeostasis and metabolic regulation, showing potential as prognostic biomarkers for stroke. This study aimed to evaluate the associations of plasma Gln, Glu, and glutamine‐to‐gl...

Effect of Nano‐CeO 2 Powder on Microstructure and Wear Resistance of Deloro 40 Coating Prepared by Laser Additive Manufacturing

In this study, a series of Deloro40 + x CeO 2 ( x = 0, 0.5, 1, 2, and 5 wt%) coatings were fabricated on SS316L stainless steel by laser additive manufacturing. The microstructure evolution, mechanical properties, and tribological behaviors of the deposited coatings were systemat...

Activatable Bioorthogonal Imaging of Radiotherapy-Induced Glucose Flux with Cell-Lineage Resolution

Abstract Glucose uptake in the tumor microenvironment is closely linked to both malignant progression and immune function. Radiotherapy reshapes glucose utilization across different cell populations, yet distinguishing cell-lineage-specific uptake changes remains a major technica...

Toward Integrated Upcycling of Lithium‐Ion Battery: Advances and Outlooks

The imminent retirement of large batches of lithium‐ion batteries poses a critical challenge to sustainable resource management. While present recycling technologies have demonstrated certain advantages over conventional metallurgical methods, the comprehensive assessment of thei...