Soochow University

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

ABSTRACT Immune surveillance hinges on the precise regulation of molecular sentinels to maintain the equilibrium between physiological homeostasis and pathological distress. Central to this process is the sensing of exogenous pathogen‐associated molecular patterns (PAMPs) and end...

Early gastric carcinoma with lymphoid stroma associated with a low risk of lymph node metastasis and favorable prognosis: a multicenter study in a Chinese population

Abstract Objective Gastric carcinoma with lymphoid stroma is a rare subtype of gastric carcinoma. The clinicopathological features and prognosis of early gastric carcinoma with lymphoid stroma (EGCLS) remain elusive, especially in Chinese populations. Methods In this study, we in...

Integrative single-cell and machine-learning analysis identifies LGALS1 as a macrophage-associated diagnostic and prognostic biomarker in hepatocellular carcinoma

Background Hepatocellular carcinoma (HCC) is characterized by marked heterogeneity and an immunosuppressive microenvironment in which tumor-associated macrophages contribute to disease progression. This study aimed to identify macrophage-associated biomarkers with diagnostic, pro...

Melanins Enhance Radical Scavenging Through Wavelength‐Selective Excited‐State Manifold Diversity

ABSTRACT Melanin is a ubiquitous pigment that mitigates photoinduced damage in biological systems through light absorption, heat dissipation, and radical scavenging. While these functions have traditionally been considered independent, recent studies suggest that they may be intr...

Association between albumin-bilirubin score and mortality risk in patients with acute myocardial infarction: a retrospective study based on MIMIC-IV

The albumin-bilirubin (ALBI) score, a liver function indicator, has a not fully established prognostic association with acute myocardial infarction (AMI) mortality. Our study sought to investigate the adjusted association of the ALBI score with all-cause mortality (ACM) in this p...

Laboratory aspirin resistance and the incidence of preeclampsia under prophylactic low-dose aspirin therapy: a systematic review and meta-analysis

A subset of pregnant women treated with prophylactic low-dose aspirin (LDA) still develop preeclampsia (PE), a severe pregnancy-related complication. It is hypothesized that laboratory aspirin resistance (LAR), which may undermine the preventive efficacy of LDA, is associated wit...

Phase‐Controlled Bi 2 O 3 Nanosheets for Highly Efficient Electrochemical CO 2 Reduction to Formate

ABSTRACT The electrochemical carbon dioxide reduction reaction (CO 2 RR) offers a sustainable route to convert CO 2 into valuable chemicals, with formic acid being one of the most economically attractive products. Bismuth (Bi)‐based materials have shown promise as CO 2 RR electro...

Drosha in mesangial cells regulates glomerular capillary tufts formation through drosha/ribosome/Gata3 axis

Abstract Drosha is a critical regulator of kidney development; its loss or mutation, identified in a subsets of Wilms tumor (WT), a pediatric kidney cancer, leads to nephric cap mesenchyme developmental defects. Here, we investigated the role of Drosha in mesangial cells and its...

Association Between Vitamin D and Muscle Mass and Function in Children and Adolescents

OBJECTIVE: This study aimed to investigate the association between vitamin D and muscle health in children and adolescents. DESIGN: A cross-sectional analysis was performed using data from 2,775 participants aged 8-17 years in NHANES 2011-2014. Muscle mass was evaluated through w...

Cholesteric Liquid Crystal Elastomer-Based Single-Ion Conductor for Advanced Quasi-Solid Electrolyte Membranes

Self-assembled liquid crystal polymer networks build directional transport channels via molecular alignment, enabling efficient and ordered lithium-ion migration, while single-ion conducting polymer electrolytes improve lithium-ion transference number by covalently anchoring anio...

Prognostic value of systemic immune‐inflammation index and systemic inflammation response index with maternal gestational diabetes mellitus: A systematic review and meta‐analysis

OBJECTIVE: Mounting evidence indicates that the systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) might be associated with the risk of gestational diabetes mellitus (GDM). However, existing findings remain inconclusive. This systematic revie...

A Comprehensive Assessment Framework for the Sustainable Ecological Carrying Capacity of Chinese Cities Based on Time-Series Uncertainty and Interval-Valued Fermatean Fuzzy Sets

The assessment of sustainable ecological carrying capacity (SECC) serves as a crucial scientific foundation for supporting high-quality urbanization, advancing ecological civilization, and achieving the strategic goals of the “Dual Carbon” initiative. However, existing assessment...

Synergistic Molecular Modulation via Coordination and Hydrogen Bonding for Efficient Perovskite and Tandem Solar Cells

ABSTRACT Molecular additives offer a powerful route to control crystallization kinetics and homogenize component distribution in perovskite semiconductors. However, additives that integrate Pb‐related coordination and hydrogen‐bonding functionalities within a single molecular fra...

Gut microbiota-derived indoleacrylic acid ameliorates rheumatoid arthritis by preventing necroptosis of fibroblast-like synoviocytes and regulating macrophage polarization

Rheumatoid arthritis (RA) is associated with gut metabolite dysfunction, but the contribution of tryptophan-derived metabolites to RA remains fully uncharacterized. Here, we investigated the role of the gut microbiota-derived tryptophan metabolite indoleacrylic acid (IA) in exper...

Ultra-fast battery health estimation from random 100 mV charging fragments using conditional generative diffusion

State-of-health (SOH) estimation is essential for lithium-ion battery management. However, real-world disruptions often result in fragmented battery data, making reliable SOH estimation challenging. Generative artificial intelligence offers a promising paradigm to address these l...

Astaxanthin supplementation and cardiometabolic risk factors in overweight and obese adults: a GRADE-assessed systematic review and meta-analysis

Astaxanthin, a marine-derived carotenoid, has shown antioxidant and anti-inflammatory properties in studies. However, its effects on cardiometabolic risk factors in overweight and obese populations remain inconclusive. Therefore, this systematic review and meta-analysis aimed to...

The influence of position effects of repeated items in non-strict sequences on the distance effect and reverse distance effect

This study systematically investigated the sequential processing mechanisms in non-strict sequences (sequences containing repeated items) through four experiments, examining how sequence length, item repetition position, and material type modulate distance effect patterns. Experi...

An Integrated dual-mode NIR Screening Device Forged by Spectrally Engineered Perovskite pc-LEDs

Abstract Translating advanced luminescent materials into field-deployable screening tools remains a core challenge, demanding synergy between advanced optical materials and device engineering. Here, we demonstrate a portable dual-mode near-infrared semi-quantitative screening dev...

Vitality Measurement and Smart Governance Strategies for Marginal Communities in Suzhou: A Study Based on the Vision of an International and Modern People-Oriented City

Accelerating the construction of an international, modern, and people-oriented city, Suzhou often faces bottlenecks in its peripheral communities. These open spaces suffer from rapid vitality decline, extensive governance, and weak resilience, which directly hinder residents’ dai...

Association Between Cognitively Stimulating Activities and Cognitive Function in Older Adults Living in Residential Care Homes

OBJECTIVE: To examine the relationship between cognitively stimulating activities and cognitive function among older adults in residential care homes. METHODS: A convenience sampling method was used to recruit older adults from three residential care homes in East China. Data wer...