Shanxi Medical University

The SIRT1-ΔExon8 transcript is differentially expressed across brain regions and during neural stem cell differentiation in rats

SIRT1 is an NAD+-dependent deacetylase involved in the maintenance and differentiation of neural stem cells (NSCs). Although alternative splicing increases the regulatory complexity of SIRT1, its splice isoforms in the rat nervous system remain poorly defined. This study aimed to...

Fuzuloparib in combination with apatinib versus fuzuloparib alone for recurrent ovarian cancer: a randomized, open-label, phase 2 trial

A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...

Integrating Network Pharmacology and Metabolomics to Elucidate the Mechanism of Allopurinol in Hyperuricemia Treatment

This study integrated network pharmacology and metabolomics to investigate the mechanism of allopurinol in treating hyperuricemia (HUA). Therapeutic targets were identified by screening drug and disease databases. A drug-target-disease network was constructed and validated by mol...

The genetic association between celiac disease and risk of functional dyspepsia

Celiac disease (CeD) is a common autoimmune disease of the small intestine triggered by ingesting gluten-containing foods. Chronic symptoms are characteristic of functional dyspepsia (FD), including chronic epigastric pain and burning. The clinical and genetic overlap between FD...

Distinct Profiles of Heart-Focused Anxiety and Their Association with Kinesiophobia Among Patients with Coronary Heart Disease: A Cross-Sectional Study

Jingwen Qin, Jiamin Li, Yan Zhou, Ping Yu, Xin Wang, Xin Pan, Kaizheng Gong; Distinct Profiles of Heart-Focused Anxiety and Their Association with Kinesiop

An integrative view of bile acids

Abstract Bile acids (BAs) are an important metabolic product in the human body, synthesized by the liver and existing in the form of steroid molecules. They are primarily excreted into the intestine via the gallbladder to assist in the digestion and absorption of fats. While the...

Early oseltamivir initiation and influenza outcomes in kidney transplant recipients: a multicenter real-world study

Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...

Toward therapnostic integration as a new paradigm for precision management of interstitial cystitis driven by medical-engineering convergence

Abstract Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a complex chronic inflammatory disease involving mucosal barrier defects, neurogenic inflammation, mast cell activation, and tissue remodeling. Current diagnosis lacks objective biomarkers, relying instead on sympto...

Fertility-related distress and female identity reconstruction among reproductive-age women with breast cancer in China: a qualitative study

Breast cancer is increasingly diagnosed among Chinese women of childbearing age. Cancer treatments carry variable gonadotoxic risks that participants feared could lead to lasting reproductive impairment, triggering widespread fertility-related distress closely intertwined with fe...

Female infertility in nonclassic congenital adrenal hyperplasia: beyond hyperandrogenism

Nonclassic congenital adrenal hyperplasia (NCCAH) is a common autosomal recessive endocrinopathy, primarily caused by partial 21-hydroxylase ( CYP21A2 ) deficiency, and represents a significant but often underrecognized cause of female infertility. Clinically, affected women freq...

Discoveryof High-Affinity Peptide Ligands Targetingthe SPIN1 Tudor 3 Domain Via a Minimalist Pruning Strategy

Abstract Spindlin1 (SPIN1) is an epigenetic reader involved in oncology, whose third Tudor domain remains largely underexplored. Here, we applied a minimalist pruning strategy to the 26-mer peptide DOCpep3 to identify the core pharmacophore for SPIN1 Tudor 3 domain binding. This...

Rising burden and deepening inequalities: a national study of high BMI-related uterine cancer in the United States using GBD and NHANES data

OBJECTIVE: Uterine cancer mortality is rising in the U.S. while other cancer deaths decline, posing a major public health challenge. High BMI is the strongest modifiable risk factor, but its full burden and associated inequalities remain poorly characterized. METHODS: Using data...

From synthesis to clinic: a task-specific framework for CT images metal artifact reduction in cervical brachytherapy

Severe metal artifacts in cervical brachytherapy CT scans obscure critical anatomical structures and applicator geometry. Existing metal artifact reduction (MAR) models are inadequate in addressing these complex artifacts, leading to uncertainties in organs at risk (OARs) delinea...

Novel Autoantibodies in Rheumatoid Arthritis: Translational Prospects from Seronegative Breakthrough to Precision Diagnosis and Treatment

Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic, erosive synovitis. While significant progress and breakthroughs have been made in disease diagnosis through basic research and clinical practice, approximately 30%–40% of seronegative RA patients still e...

Association between living environmental quality and risk of gastrointestinal diseases among middle-aged and older adults: evidence from a national study

Abstract Background With the rapid progression of population aging in China, gastrointestinal (GI) diseases have become one of the most common chronic conditions among middle-aged and older adults, substantially impairing quality of life and increasing healthcare burdens. However...

Ecological Restoration of Degraded Mining Soils Through Key‐Layer Construction Using Industrial By‐Products: A Comprehensive Analysis of Soil Physics, Microbiology, and Maize Yield

ABSTRACT Coal mining severely degrades soil profiles and ecosystem functions, highlighting the need for effective reclamation. Reconstructing soil profiles with industrial solid wastes offers a promising waste‐to‐resource approach, but the ecological effects of different engineer...

Externally Validated Plasma Phospholipid Panel for Pneumoconiosis Triage Across Dust-Exposed and Unexposed Worker Cohorts

Objective: To evaluate whether targeted plasma phospholipidomics identifies an externally validated blood panel for pneumoconiosis triage across dust-exposed and nonexposed worker cohorts. Methods: We quantified 53 plasma phospholipids by UPLC-MS/MS in discovery (n=392) and exter...

Application and cross-cultural validation of the ASAS HI-based health state utility algorithm in Chinese patients with spondyloarthritis

Health State Utility (HSU) reflects individual preferences for specific health states and serve as a core parameter in health economic evaluations. Spondyloarthritis (SpA), a group of rheumatic diseases characterized by chronic back pain and joint involvement, imposes a substanti...

Transcriptomic and Metabolomic Analysis Following LmRab11A Knockdown Reveals Its Role in Metabolic Regulation and Molting in Locusta migratoria

Rab proteins are key members of the Ras superfamily that regulate vesicular trafficking in eukaryotic cells, ensuring accurate cargo transport and cellular homeostasis. To investigate the functional role of Rab proteins, RNA interference (RNAi) was employed to silence LmRab11A in...

Age-related degeneration initiates at the surface: preferential biomechanical and biological decline in rat articular cartilage

Age-related degeneration of articular cartilage is a key pathological hallmark of primary osteoarthritis (OA). As the cartilage’s barrier layer, the superficial zone maintains tissue homeostasis and is increasingly recognized as the initial site of age-related cartilage degenerat...