Shanxi Medical University

Knowledge, attitudes, and practices regarding Helicobacter pylori resistance among physicians: a multicenter cross-sectional study in Shanxi, China

This study aimed to explore physicians’ knowledge, attitudes, and practices (KAP) regarding Helicobacter pylori ( H. pylori ) resistance to treatment in Shanxi Province, Central China. A multicenter, cross-sectional study was conducted from August to October 2024, enrolling physi...

A cross-sectional analysis and forward projection of China’s gallbladder and biliary-tract cancer burden

Gallbladder and biliary tract cancer (GBTC) remains highly lethal. We examined 32-year epidemiological trends in China and projected outcomes to 2050. Using 2021 Global Burden of Disease (GBD) data, we extracted annual GBTC incident and prevalent cases, deaths, and disability-adj...

From Single-Modal Signal Recognition to Multidimensional Precision Detection: Breakthroughs and Innovations of Multi-Modal Sensors in Tumor Biomarker Detection

The sensitive detection of tumor markers is of great significance for clinical diagnosis. Due to the extremely low abundance of early tumor biomarkers and severe background interference from biological matrices, traditional single-modal atomolar biological testing generally has l...

Ki-67 Proliferation Index Improves the Prognostic Stratification Accuracy of International Staging System in Newly Diagnosed Multiple Myeloma

Objective: To investigate the clinical characteristics and prognostic significance of distinct Ki-67 proliferation indices in patients with newly diagnosed multiple myeloma (NDMM). Methods: A retrospective analysis of clinical data from 307 NDMM patients admitted to the Second Ho...

Focusing on VaIN2 +: Development and validation of a prediction nomogram based on a large colposcopy population

Abstract Introduction Vaginal intraepithelial neoplasia 2 or worse (VaIN2+) has long remained in a largely passive diagnostic pattern due to the lack of specific clinical manifestations and routine screening strategies. This study aimed to explore its clinical characteristics and...

The role of plasma oxytocin in early-onset schizophrenia: implications for disease severity and early intervention

INTRODUCTION: Early-onset schizophrenia (EOS) is a severe psychiatric disorder with poor long-term outcomes. It offers a unique opportunity to examine the neurobiological mechanisms of schizophrenia without the confounding effects of adult environmental factors. Oxytocin (OXT), a...

Hyaluronic Acid Microneedle With α‐Boswellic Acid Heal Oral Ulcers by Anti‐inflammatory Activity

OBJECTIVE: Conventional topical therapies for oral ulcers remain limited due to poor mucosal adhesion and rapid clearance by saliva. To overcome these challenges, we aimed to develop a microneedle patch with α-boswellic acid for targeted anti-inflammatory treatment of oral ulcers...

Bio-inspired nanochannel sensors for detecting gaseous signaling molecules

Drawing inspiration from natural biosensing, researchers have developed artificial nanochannels that enable efficient target detection through transmembrane ionic current readout. These nanochannel sensors exhibit distinctive nanoconfined phenomena in their selectivity, gating, a...

Adaptive Integrated Microfluidic System with Real-Time Dielectric Feedback for Deterministic Micro-Manipulation

Abstract Conventional microfluidic particle sorting systems predominantly rely on static, open-loop operational principles, rendering them highly vulnerable to performance deterioration induced by cellular phenotypic heterogeneity and localized hydrodynamic fluctuations. Here, we...

Nanozymes in Upper Respiratory Tract Infections: Catalytic Mechanisms, Current Evidence, and Emerging Theranostic Strategies

Abstract Objective: This review evaluates nanozymes as catalytic biomaterials for upper respiratory tract infection (URTI)-related diagnosis, therapy, and prevention, with particular attention to differences in the maturity of evidence across these applications. The anatomically...

Association of inflammatory biomarkers and pericoronary fat attenuation index with coronary functional ischemia in patients with metabolic dysfunction-associated fatty liver disease

Patients with metabolic dysfunction-associated fatty liver disease (MAFLD) and coronary heart disease (CHD) exhibit systemic and coronary inflammation. However, the value of integrating systemic inflammatory biomarkers and the pericoronary fat attenuation index (FAI) for identify...

Effects of laparoscopic radiofrequency ablation combined with a levonorgestrel-releasing intrauterine system in patients with adenomyosis

To compare the 12-month clinical outcomes of laparoscopic RFA alone with those of laparoscopic RFA combined with LNG-IUS in patients with symptomatic adenomyosis. This single-center retrospective cohort study included 70 patients with adenomyosis who had complete 12-month follow-...

AI-assisted telerehabilitation in early Parkinson’s disease: a multicenter, randomized, multi-arm comparative trial

Abstract This exploratory, multicenter, randomized, rater-blinded, multi-arm comparative trial aimed to evaluate the feasibility and exploratory clinical signals of an AI-facilitated telerehabilitation system across different intervention durations in early-stage Parkinson’s dise...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Efficacy and Safety of Chemically Synthesized Semaglutide Injection ( HD1916 ) for the Treatment of Obesity: A Multicenter, Randomized, Phase III Trial

ABSTRACT Aims To evaluate whether HD1916, a chemically synthesised semaglutide, is therapeutically equivalent to the reference product semaglutide (Wegovy) in body weight reduction among Chinese adults with obesity without diabetes. Materials and Methods This multicenter, randomi...

A protein-prioritised, colocalisation-informed genetic framework for safety hypothesis generation across inflammatory bowel disease therapeutic pathways

Human genetics can help prioritise target–outcome safety hypotheses before broad therapeutic exposure, but the strength and translational meaning of such signals depend on molecular proxy type, locus specificity and instrument architecture. We developed a protein-prioritised, col...

Transillumination improves lymph node yield in left-sided colorectal cancer: an ambispective cohort study

Accurate lymph node (LN) staging is essential for prognosis and treatment decisions in colorectal cancer (CRC). Existing methods to assist LN retrieval, such as fat-clearing and methylene blue staining, improve yield but are complex, time-consuming, and require additional reagent...

Circ_0000745 Attenuates Sepsis-Induced Acute Kidney Injury Via the MiR‑671‑5p/IGFBP3 Axis, with Associated Changes in Autophagy-Related Markers

Sepsis-induced acute kidney injury (SAKI) is a frequent and life-threatening complication that currently lacks standardized therapeutic strategies. Circular RNAs have emerged as critical regulators in SAKI pathogenesis, and circ_0000745 has been identified as significantly downre...

FAM45A-Mediated Persistent Memory-Like Fibroblast Reprogramming Drives PM2.5-Exacerbated Allergic Asthma

Abstract Chronic coexposure to fine particulate matter (PM2.5) and house dust mite (HDM) allergen worsens allergic asthma outcomes, yet the stromal cell mechanisms linking combined environmental and allergic risk factors remain incompletely defined. Airway fibroblasts are traditi...

Moldavoside ameliorates hypertension and autoantibodies targeting the angiotensin II type 1 receptor-induced endothelial damage via regulation of RhoE/CAV-1/eNOS axis

Globally, more than 100 million patients with resistant hypertension experience severe endothelial damage. Therefore, exploring the mechanisms underlying endothelial damage and developing effective interventions is urgently required. The clinical data and biochemical indicators o...