Shanxi Medical University

Carbapenem-Resistant Gram-Negative Bacilli in China: Current Situation and Trend Inference (2014–2029)

The objective of this study was to analyze longitudinal trends in the detection rates of Carbapenem-resistant Gram-negative bacilli (CRGNB) in China from 2014 to 2024, and to forecast their evolution over the subsequent five years. Surveillance data were extracted from the annual...

Distribution of human papillomavirus in cervical, vaginal and vulvar lesions: a single-center retrospective study from Shanxi, China

Unlike the well-studied cervical cancer caused by human papillomavirus (HPV), there is a lack of epidemiological data on HPV, which covers the entire lower genital tract and has regional characteristics. This study investigated the HPV distribution in cervical, vaginal and vulvar...

Noise‐Resistant Correlated Biphoton Imaging Based on the Superbunching Emission From Single Colloidal Quantum Dots

ABSTRACT Quantum‐correlated techniques enable high‐contrast and super‐resolution imaging through the feature of correlated photons. The superbunching effect with a second‐order correlation larger than 2, i.e., g (2) (0) > 2, demonstrates the existence of strong correlations betwe...

Flood redistribution and hydraulic responses to controlled levee breaching in highly Leveed urban rivers

Study region Study region: The upper reach of the Ganjiang River in Ganzhou, Jiangxi Province, China, where rapid urbanization and extensive levee systems have increased exposure to extreme flood hazards. Study focus A coupled 1D-2D hydrodynamic model (GAST) was applied to simula...

Tiered diagnosis and value-based healthcare: can the outpatient reimbursement policy for medical costs in retail pharmacies promote both?

Amid growing health demands and tight welfare budgets, guiding rational healthcare-seeking behavior to improve health while controlling costs has become a global challenge. This study aims to examine whether the reform of medical insurance on the cost-sharing of pharmacy can prom...

ZMIZ1 promotes aerobic glycolysis and development of hepatocellular carcinoma through inducing NOTCH1-mediated transcription of PYCR1

Hepatocellular carcinoma (HCC) is characterized by profound metabolic reprogramming that promotes tumor progression. Although zinc finger MIZ-type containing 1 (ZMIZ1) has been implicated in several malignancies, its biological function and underlying mechanism in HCC remain uncl...

The SIRT1-ΔExon8 transcript is differentially expressed across brain regions and during neural stem cell differentiation in rats

SIRT1 is an NAD+-dependent deacetylase involved in the maintenance and differentiation of neural stem cells (NSCs). Although alternative splicing increases the regulatory complexity of SIRT1, its splice isoforms in the rat nervous system remain poorly defined. This study aimed to...

Endpoint-specific associations of the cholesterol, high-density lipoprotein, and glucose (CHG) index and its adiposity- and inflammation-related derivatives with incident cardiovascular disease and mortality: evidence from CHARLS and NHANES

The cholesterol-high-density lipoprotein–glucose (CHG) index combines lipid and glycemic measures, but whether its adiposity- and inflammation-related derivatives add information beyond their components and established risk factors is uncertain. We compared nine CHG-related indic...

Fuzuloparib in combination with apatinib versus fuzuloparib alone for recurrent ovarian cancer: a randomized, open-label, phase 2 trial

A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...

Integrating Network Pharmacology and Metabolomics to Elucidate the Mechanism of Allopurinol in Hyperuricemia Treatment

This study integrated network pharmacology and metabolomics to investigate the mechanism of allopurinol in treating hyperuricemia (HUA). Therapeutic targets were identified by screening drug and disease databases. A drug-target-disease network was constructed and validated by mol...

An integrative view of bile acids

Abstract Bile acids (BAs) are an important metabolic product in the human body, synthesized by the liver and existing in the form of steroid molecules. They are primarily excreted into the intestine via the gallbladder to assist in the digestion and absorption of fats. While the...

The genetic association between celiac disease and risk of functional dyspepsia

Celiac disease (CeD) is a common autoimmune disease of the small intestine triggered by ingesting gluten-containing foods. Chronic symptoms are characteristic of functional dyspepsia (FD), including chronic epigastric pain and burning. The clinical and genetic overlap between FD...

Distinct Profiles of Heart-Focused Anxiety and Their Association with Kinesiophobia Among Patients with Coronary Heart Disease: A Cross-Sectional Study

Jingwen Qin, Jiamin Li, Yan Zhou, Ping Yu, Xin Wang, Xin Pan, Kaizheng Gong; Distinct Profiles of Heart-Focused Anxiety and Their Association with Kinesiop

Early oseltamivir initiation and influenza outcomes in kidney transplant recipients: a multicenter real-world study

Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...

Toward therapnostic integration as a new paradigm for precision management of interstitial cystitis driven by medical-engineering convergence

Abstract Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a complex chronic inflammatory disease involving mucosal barrier defects, neurogenic inflammation, mast cell activation, and tissue remodeling. Current diagnosis lacks objective biomarkers, relying instead on sympto...

Female infertility in nonclassic congenital adrenal hyperplasia: beyond hyperandrogenism

Nonclassic congenital adrenal hyperplasia (NCCAH) is a common autosomal recessive endocrinopathy, primarily caused by partial 21-hydroxylase ( CYP21A2 ) deficiency, and represents a significant but often underrecognized cause of female infertility. Clinically, affected women freq...

Fertility-related distress and female identity reconstruction among reproductive-age women with breast cancer in China: a qualitative study

Breast cancer is increasingly diagnosed among Chinese women of childbearing age. Cancer treatments carry variable gonadotoxic risks that participants feared could lead to lasting reproductive impairment, triggering widespread fertility-related distress closely intertwined with fe...

Rising burden and deepening inequalities: a national study of high BMI-related uterine cancer in the United States using GBD and NHANES data

OBJECTIVE: Uterine cancer mortality is rising in the U.S. while other cancer deaths decline, posing a major public health challenge. High BMI is the strongest modifiable risk factor, but its full burden and associated inequalities remain poorly characterized. METHODS: Using data...

Discoveryof High-Affinity Peptide Ligands Targetingthe SPIN1 Tudor 3 Domain Via a Minimalist Pruning Strategy

Abstract Spindlin1 (SPIN1) is an epigenetic reader involved in oncology, whose third Tudor domain remains largely underexplored. Here, we applied a minimalist pruning strategy to the 26-mer peptide DOCpep3 to identify the core pharmacophore for SPIN1 Tudor 3 domain binding. This...

From synthesis to clinic: a task-specific framework for CT images metal artifact reduction in cervical brachytherapy

Severe metal artifacts in cervical brachytherapy CT scans obscure critical anatomical structures and applicator geometry. Existing metal artifact reduction (MAR) models are inadequate in addressing these complex artifacts, leading to uncertainties in organs at risk (OARs) delinea...