Shanxi Medical University

Exploratory evaluation of large language models in patient-oriented orthopedic MRI report interpretation: a two-stage study

Abstract Background Magnetic resonance imaging (MRI) reports for orthopedic conditions are filled with highly specialized terminology, leading to information asymmetry between clinicians and patients. Deficiencies persist in routine patient education regarding orthopedic imaging...

Stress hyperglycemia ratio as a risk factor for delirium in older intensive care unit patients: a retrospective cohort study

Delirium is a severe neurocognitive complication in older ICU patients, associated with poor outcomes. The stress hyperglycemia ratio (SHR), reflecting acute hyperglycemia relative to chronic glycemic control, may predict adverse outcomes. This study examined the association betw...

Decision fusion model for predicting WHO/ISUP grade of clear cell renal cell carcinoma based on multi-phase CT radiomics: a multicenter study

The pathological grading of clear cell renal cell carcinoma (ccRCC) plays a critical role in both its diagnosis and treatment. This study aimed to develop a decision fusion model based on multi-phase CT to predict the WHO/ISUP grade of ccRCC. This retrospective study included cli...

Surface Modification of Sulfonated Carbon Fiber-Reinforced Polyetheretherketone Composite by Polydopamine-Assisted nHA/Zn/CMCS and Its Evaluation of Osteogenic Properties

OBJECTIVE: Carbon fiber-reinforced polyetheretherketone (CF/PEEK) possesses the elastic modulus similar to that of natural bone, yet its inherent surface hydrophobicity and bio-inertness restrict its application in oral implantation. To overcome this limitation, this study propos...

18F-PSMA-1007 PET/CT in PSMA-avid bladder urothelial carcinoma with extensive bone metastases: a case report

Abstract Background: PSMA PET can accurately localize PSMA-expressing lesions. However, PSMA expression is not limited to prostate cancer cells but is also widely present in the neovascular endothelial cells of various solid tumors. Case presentation: We present a case of urothel...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Nighttime Sensory–Behavioral Activation and Admission Suicidality in Young Inpatients With Major Depressive Disorder: A Retrospective Clinical‐Record Study

INTRODUCTION: Suicide risk assessment during psychiatric admission may benefit from clinically observable information beyond overall depressive symptom severity. This study examined whether clinician-documented nighttime sensory-behavioral activation was associated with admission...

The revelation of immune cell interaction and the building of a prognostic model in diffuse large B-cell lymphoma under Hedgehog signaling abnormalities based on single-cell data

The Hedgehog (Hh) signaling pathway is activated in diffuse large B-cell lymphoma (DLBCL) and helps facilitate tumor cell survival and proliferation. Currently, the role of the Hh signaling pathway in the prognosis of DLBCL has yet to be thoroughly investigated. RNA-Seq data and...

Effectiveness of digital health interventions for the management of Low Anterior Resection Syndrome (LARS) after sphincter-preserving surgery for rectal cancer: a systematic review and meta-analysis

Low anterior resection syndrome (LARS) frequently occurs following sphincter-preserving rectal cancer surgery. Although recent studies have reported the effects of digital health interventions for LARS management, no systematic review and meta-analysis has been conducted. We sear...

SLC7A11-associated astrocyte states are linked to redox imbalance and synaptic microenvironment remodeling in multiple sclerosis: translational implications

Abstract Background Multiple sclerosis (MS) is characterized by inflammatory demyelination, oxidative stress, and neurological dysfunction. Despite disease-modifying therapies, chronic active lesions and ongoing neurodegeneration remain largely untreated, highlighting the need fo...

Association Between the Non-High-Density Lipoprotein/High-Density Lipoprotein Cholesterol Ratio and Sarcopenia in Older Chinese Men.

=0.164）. Conclusions NHHR is inversely associated with sarcopenia risk among older Chinese men，while this association is substantially attenuated after adjustment for BMI，suggesting it may be largely confounded by body size or obesity-related factors.These findings should be i...

Woven dECM yarn scaffolds enable volumetric muscle loss regeneration via immunomodulation

Volumetric muscle loss (VML) represents a significant unmet clinical need in current medical practice. Decellularized extracellular matrix (dECM) offers a promising clinical approach. However, its inherent architecture impedes adaptive topological guidance for rapid cellular infi...

Small extracellular vesicles induced by Angiotensin-(1-7) enhance cardioprotection following myocardial ischemia-reperfusion injury

Although Angiotensin-(1-7) [Ang-(1-7)], a non-classical peptide of the renin-angiotensin system (RAS), is widely recognized for alleviating cardiovascular stress through activation of the Mas receptor. we identified a largely Mas receptor-independent pathway that expands its ther...

Complete genome-derived metabolic interactions reveal the impact of gut ecology on human health

Abstract Metabolic interactions govern gut microbiome assembly, yet functional rules remain obscured by genomic incompleteness and fragmentation. Here, we leverage 1,150 complete genomes to construct genome-scale metabolic models, demonstrating that draft genomes introduce system...

The optimal neoadjuvant modality in locally advanced gastric cancer in the era of immune-drugs: a multicenter retrospective analysis

Optimal neoadjuvant strategies for locally advanced gastric cancer (LAGC) remain contentious. The purpose of this study was to compare the survival prognosis and safety of LAGC receiving three different neoadjuvant modalities. In this multicenter retrospective cohort, 670 patient...

Efficacy, safety, and pharmacokinetics of pumecitinib nasal spray for moderate-to-severe seasonal allergic rhinitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Background Seasonal allergic rhinitis (SAR) is a pollen-triggered condition causing nasal inflammation and quality of life impairment. Pumecitinib, a topical Janus kinase (JAK) inhibitor may modulate allergic inflammation. We evaluated the efficacy, safety, and pharmacokinetics o...

Distribution of human papillomavirus in cervical, vaginal and vulvar lesions: a single-center retrospective study from Shanxi, China

Unlike the well-studied cervical cancer caused by human papillomavirus (HPV), there is a lack of epidemiological data on HPV, which covers the entire lower genital tract and has regional characteristics. This study investigated the HPV distribution in cervical, vaginal and vulvar...

Noise‐Resistant Correlated Biphoton Imaging Based on the Superbunching Emission From Single Colloidal Quantum Dots

ABSTRACT Quantum‐correlated techniques enable high‐contrast and super‐resolution imaging through the feature of correlated photons. The superbunching effect with a second‐order correlation larger than 2, i.e., g (2) (0) > 2, demonstrates the existence of strong correlations betwe...

Tiered diagnosis and value-based healthcare: can the outpatient reimbursement policy for medical costs in retail pharmacies promote both?

Amid growing health demands and tight welfare budgets, guiding rational healthcare-seeking behavior to improve health while controlling costs has become a global challenge. This study aims to examine whether the reform of medical insurance on the cost-sharing of pharmacy can prom...

Flood redistribution and hydraulic responses to controlled levee breaching in highly Leveed urban rivers

Study region Study region: The upper reach of the Ganjiang River in Ganzhou, Jiangxi Province, China, where rapid urbanization and extensive levee systems have increased exposure to extreme flood hazards. Study focus A coupled 1D-2D hydrodynamic model (GAST) was applied to simula...