Shanxi Medical University

OMA1-Mediated Mitochondrial Stress Exacerbates PANoptosis in Macrophages Via the mtROS-ZBP1 Axis in Coal Dust-Exposed Asthma

This study aimed to elucidate the mechanisms by which coal dust exposure (CDE) exacerbates asthma, focusing on macrophage mitochondrial dysfunction and programmed cell death, and identifying the key regulatory molecules involved. Control, CDE, Asth, and CDE+Asth mouse models were...

The comorbidity of hypertension and diabetes modifies the association of body roundness index with chronic kidney disease: findings from two cross-sectional studies in China and the US

This study aimed to investigate the potential effect of the comorbidity of hypertension and diabetes on the association of body roundness index (BRI) with chronic kidney disease (CKD). A total of 20,261 participants from Fuqing Cohort Study (FQCS) in China and 6,434 participants...

Integrating Multimodal MRI Habitat and Transformer‐Based Pathomics to Predict High‐Risk Molecular Subtypes and Explore Biological Mechanisms in Adult Diffuse Gliomas

BACKGROUND: This study aims to achieve accurate prediction of high-risk molecular subtypes of gliomas through a cross-scale Combined model, matching the model's classification metrics with patient risk stratification and exploring the underlying biological mechanisms. METHODS: Th...

Systems toxicology prioritization of HSD11B1 as a candidate PFOA-related metabolic homeostasis node in adrenocortical carcinoma

This study aimed to construct a hypothesis-generating evidence framework linking PFOA-related molecular target annotations to biological alterations in adrenocortical carcinoma (ACC), with emphasis on HSD11B1 as a downregulated adrenal metabolic homeostasis node and an in silico...

Associations Between Kidney Function and Risk of Cognitive Impairment Among Chinese Older Adults

ABSTRACT Background The association between kidney function and dementia remains inconsistent across studies, and its relationship in older adults is unclear. This study aimed to investigate the longitudinal associations between kidney dysfunction, assessed by estimated glomerula...

Hierarchically Porous Silver–Carbon Composite with Dialyzable Silver Release for Biofilm Control and Healing of Infected Wounds

Abstract Biofilm-associated wound infections require antibacterial materials that can control attached bacteria while limiting excessive silver exposure. In this study, we prepared a sponge-like hierarchical porous silver–carbon material through in situ glucose foaming and carbon...

Development of a recurrence risk prediction model for intracranial atherosclerotic stroke using HR-VWI combined with radiomics

Based on high-resolution vessel wall imaging (HR-VWI) and radiomics, this study constructed a predictive model for stroke recurrence in patients with symptomatic intracranial atherosclerotic stenosis (sICAS), and evaluated the performance of the model. This study retrospectively...

Association between dietary vitamin B6 intake and total bone mineral density in adolescents: a cross-sectional study of NHANES 2011–2018

Adolescence is a critical period for peak bone mass acquisition, which plays a pivotal role in lifelong skeletal health. However, the association between dietary vitamin B6 intake and bone mineral density (BMD) during this developmental stage remains unclear. This study aimed to...

Identification of transcriptomic signatures associated with an ac4C related gene set and candidate expression based clusters in osteoarthritis through integrative bioinformatics

Objective To identify osteoarthritis (OA) associated transcripts overlapping a predefined N4-acetylcytidine (ac4C) related gene set and evaluate their potential as an exploratory classification signature and basis for expression based clustering. Methods Five GEO datasets were an...

Transparent ferroelectric 0.8Bi0.5Na0.5TiO3-0.2SrTiO3 resistors for neural synapse sensors and image recognition

Ferroelectric memristors possess advantages such as low operating voltage, high storage density and sub-micron-scale multi-state storage, making them widely used in fields such as information storage and mimicking biological synaptic functions. Here, the ferroelectric resistive s...

Mitochondrial Transplantation Rejuvenates Aging Heart by Restoring Mitophagy Flux via the HIF ‐3α‐ BNIP3 Axis

Mitochondrial quality control is severely impaired in the aging heart, largely attributed to disrupted mitophagy homeostasis. However, the key molecular drivers remain poorly defined, and the translational value of mitochondria-targeted therapy for cardiac aging is still underexp...

The relationship between serum FSTL1 levels and bone destruction in patients with ankylosing spondylitis

A typical autoimmune disease, ankylosing spondylitis (AS), is characterized primarily by chronic inflammation of the axial skeleton and destruction of osseous structures. Follistatin-like protein 1 (FSTL1) is a glycoprotein that regulates inflammation and bone metabolism and has...

Unravelling gut-kidney axis alterations in BPA-related CKD: Integrating network toxicology and machine learning with experimental validation

Background Chronic kidney disease (CKD) has a complex pathogenesis. Exposure to bisphenol A (BPA) is closely associated with its occurrence and development. Although it is known that BPA can affect the gut microbial community and that the gut-kidney axis serves a crucial role in...

The Role of Eccentric Contraction Training in the Postoperative Rehabilitation of Patients With Total Knee Arthroplasty

ABSTRACT Background Eccentric contraction training may be associated with improved functional recovery after total knee arthroplasty (TKA), but its effects on pain, range of motion, and patient‐reported outcomes during the early postoperative period remain unclear. This randomize...

Decisional conflict regarding fertility preservation among women of reproductive age with systemic lupus erythematosus: a cross-sectional study of its level and associated factors

To describe the level of decisional conflict regarding fertility preservation among women of reproductive age with systemic lupus erythematosus (SLE) and to identify factors associated with it. Using convenience sampling, we recruited women of reproductive age with SLE attending...

Ganoderma Lucidum Polysaccharides Potentiate Low‐Dose Gemcitabine Against 4T1 Breast Tumors, Associated With Immune Activation and Gut Microbiota Remodeling

ABSTRACT Gemcitabine (GEM), a first‐line chemotherapeutic agent, may fail to prevent recurrence in some settings. Traditional Chinese medicine emphasizes Yin–Yang balance and “fuzheng” approaches and may offer complementary strategies. Ganoderma lucidum polysaccharides (GLP) exhi...

Diffuse uterine leiomyomatosis with a mesenteric smooth muscle lesion and a reported family history of uterine leiomyomas: a case report and literature review

Abstract Background Diffuse uterine leiomyomatosis (DUL) is a rare benign smooth muscle disorder characterized by diffuse proliferation of innumerable, poorly circumscribed leiomyomatous nodules throughout the myometrium. Because its clinical and radiologic features overlap with...

Candidate plasma proteins associated with all-cause mortality among patients with prostate cancer: a UK biobank analysis

Evidence remains limited regarding circulating protein signals associated with long-term mortality among patients with prostate cancer (PCa). This study aimed to identify circulating proteins associated with long-term mortality in PCa patients and assess their potential increment...

Research on the correlation between artificial intelligence and depression

This study aims to systematically assess the research productivity of artificial intelligence (AI) technologies and depression using bibliometric methods, while also exploring the trends and prospects of AI applications in the diagnosis, prediction, and treatment of depression. T...

Multiomics profiling identifies molecular and cellular signatures of regular exercise in human peripheral blood

Regular exercise is well established to protect against metabolic disorders and bolster immunity, but the underlying molecular and cellular mechanisms remain incompletely understood. We integrated plasma metabolomics and lipidomics with single-cell transcriptomic and chromatin ac...