Shanxi Medical University

Novel Autoantibodies in Rheumatoid Arthritis: Translational Prospects from Seronegative Breakthrough to Precision Diagnosis and Treatment

Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic, erosive synovitis. While significant progress and breakthroughs have been made in disease diagnosis through basic research and clinical practice, approximately 30%–40% of seronegative RA patients still e...

Externally Validated Plasma Phospholipid Panel for Pneumoconiosis Triage Across Dust-Exposed and Unexposed Worker Cohorts

Objective: To evaluate whether targeted plasma phospholipidomics identifies an externally validated blood panel for pneumoconiosis triage across dust-exposed and nonexposed worker cohorts. Methods: We quantified 53 plasma phospholipids by UPLC-MS/MS in discovery (n=392) and exter...

Ecological Restoration of Degraded Mining Soils Through Key‐Layer Construction Using Industrial By‐Products: A Comprehensive Analysis of Soil Physics, Microbiology, and Maize Yield

ABSTRACT Coal mining severely degrades soil profiles and ecosystem functions, highlighting the need for effective reclamation. Reconstructing soil profiles with industrial solid wastes offers a promising waste‐to‐resource approach, but the ecological effects of different engineer...

Association between living environmental quality and risk of gastrointestinal diseases among middle-aged and older adults: evidence from a national study

Abstract Background With the rapid progression of population aging in China, gastrointestinal (GI) diseases have become one of the most common chronic conditions among middle-aged and older adults, substantially impairing quality of life and increasing healthcare burdens. However...

Application and cross-cultural validation of the ASAS HI-based health state utility algorithm in Chinese patients with spondyloarthritis

Health State Utility (HSU) reflects individual preferences for specific health states and serve as a core parameter in health economic evaluations. Spondyloarthritis (SpA), a group of rheumatic diseases characterized by chronic back pain and joint involvement, imposes a substanti...

Transcriptomic and Metabolomic Analysis Following LmRab11A Knockdown Reveals Its Role in Metabolic Regulation and Molting in Locusta migratoria

Rab proteins are key members of the Ras superfamily that regulate vesicular trafficking in eukaryotic cells, ensuring accurate cargo transport and cellular homeostasis. To investigate the functional role of Rab proteins, RNA interference (RNAi) was employed to silence LmRab11A in...

Age-related degeneration initiates at the surface: preferential biomechanical and biological decline in rat articular cartilage

Age-related degeneration of articular cartilage is a key pathological hallmark of primary osteoarthritis (OA). As the cartilage’s barrier layer, the superficial zone maintains tissue homeostasis and is increasingly recognized as the initial site of age-related cartilage degenerat...

Probiotic-hydrogel systems for microbiome-associated diseases: design principles, preclinical evidence, and translational challenges

The human microbiome provides a robust ecosystem for mucosal barrier function, immune regulation, metabolism, and resistance to pathogen infection. Dysbiosis causes inflammatory bowel disease, oral inflammation, wound damage, skin disease, and cancer-related immune dysregulation....

Effects of ursodeoxycholic acid on blood glucose and related metabolic indexes in type 2 diabetes rats

Bile acids (BAs) play critical roles in regulating glucose, lipid and energy metabolism, but its effects on type 2 diabetes is not very clear, we studied the effects of ursodeoxycholic acid (UDCA) intervention on blood glucose and related metabolic indexes in type 2 diabetes rats...