Shanxi Medical University

Research on the correlation between artificial intelligence and depression

This study aims to systematically assess the research productivity of artificial intelligence (AI) technologies and depression using bibliometric methods, while also exploring the trends and prospects of AI applications in the diagnosis, prediction, and treatment of depression. T...

Candidate plasma proteins associated with all-cause mortality among patients with prostate cancer: a UK biobank analysis

Evidence remains limited regarding circulating protein signals associated with long-term mortality among patients with prostate cancer (PCa). This study aimed to identify circulating proteins associated with long-term mortality in PCa patients and assess their potential increment...

Metabolic reprogramming in diabetic panvascular disease: Molecular mechanism and therapeutic strategies

Diabetes mellitus substantially increases the risk of cardiovascular, cerebrovascular, renal, retinal and peripheral vascular complications. These are collectively referred to as diabetic panvascular disease. A traditional approach that treats each complication separately is no l...

Multiomics profiling identifies molecular and cellular signatures of regular exercise in human peripheral blood

Regular exercise is well established to protect against metabolic disorders and bolster immunity, but the underlying molecular and cellular mechanisms remain incompletely understood. We integrated plasma metabolomics and lipidomics with single-cell transcriptomic and chromatin ac...

The application of nanoparticles green-formulated by Lycium barbarum leaf aqueous extract in the treatment of myocardial infarction

Cardiovascular diseases, including myocardial infarction, remain a main cause of mortality and morbidity worldwide, and raising attention has been directed toward plant-derived bioactive compounds and green nanotechnology for developing safer remedial approaches. This research de...

Association between sarcopenia and hypertension: results from large databases in China and the United States

Sarcopenia and hypertension are prevalent conditions with substantial public health implications. However, whether their association is consistent across different populations remains unclear. This study aimed to investigate the association between sarcopenia and hypertension usi...

Characterizations of the multi-kingdom gut microbiota in elderly individuals with end-stage renal disease

End-stage renal disease (ESRD) is common in older adults and has been linked to gut dysbiosis, yet multi-kingdom alterations and cross-kingdom interactions in elderly patients remain incompletely defined. We characterized the gut bacteriome, mycobiome, and virome in elderly indiv...

The relationship between serum E2F1 and MMP-9 levels and clinical and pathological characteristics and prognosis in patients with epithelial ovarian cancer

To investigate the association between serum levels of E2F transcription factor 1 (E2F1) and matrix metalloproteinase 9 (MMP-9) in patients with epithelial ovarian cancer (EOC) and their clinical and pathological characteristics and prognosis, with the aim of identifying potentia...

Multi-Endpoint Prediction of Bioactivity and ADMET Properties Coupled with Multi-Objective Optimization in Molecular Descriptor Space for Candidate ERα Antagonists

Objectives: Candidate estrogen receptor alpha (ERα) antagonists should combine strong inhibitory activity with favorable absorption, distribution, metabolism, excretion, and toxicity (ADMET)-related properties. This study developed an integrated framework for multi-endpoint predi...

EPHX2 Loss Promotes CRC Migration via EET ‐Dependent Chemokine Elevation and Mitochondrial Defect

ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and carcinogenesis. However, the role and mechanism of EPHX2 in colorectal cancer (CRC) migrati...

Death anxiety and its associated factors among palliative care nurses in China: a multicenter cross-sectional study

To investigate the current status of death anxiety among palliative care nurses, explore its associated factors based on the Conservation of Resources theory, and provide an empirical reference to inform future targeted clinical interventions. A multicenter cross-sectional study...

Development and validation of an interpretable prognostic model for in-hospital GCS-based neurological recovery after intracerebral hemorrhage in young and middle-aged adults: a multicenter retrospective cohort study

Prognostic tools for intracerebral hemorrhage (ICH) are largely derived from older or mixed-age cohorts and rarely incorporate lifestyle factors, limiting their relevance to young and middle-aged adults. We aimed to develop and externally evaluate an interpretable model for unfav...

Prevalence and risk factors of human papillomavirus infection and cervical cytological lesions among women in Shanxi, China: a cross-sectional study

Abstract Background With the introduction of human papillomavirus (HPV) vaccination into China’s national immunization programme in November 2025, robust baseline evidence on HPV epidemiology is critical. Data on HPV prevalence, genotype-specific distribution, risk factors, and t...

Smartphone Addiction Modulates Object-Based Attention

Smartphone addiction has been linked to altered attentional functioning. However, it remains unclear whether these alterations are associated with enhanced attentional bias or impaired attentional shifting. Moreover, previous studies have largely relied on self-report measures, a...

Aerobic Exercise Ameliorates Renal Injury in High‐Fat Diet‐Fed Mice: A Novel Effect Mediated by the Drp1‐mtROS Pathway

AIM: Aberrant activation of dynamin-related protein 1 (Drp1) promotes excessive mitochondrial reactive oxygen species (mtROS) production; however, whether the Drp1-mtROS pathway mediates the renoprotective effects of aerobic exercise remains unclear. METHODS: High-fat diet (HFD)-...

Development and validation of a 154-plex MPS STR panel for Illumina and Nanopore: a comprehensive tool for forensic genetic analysis

Capillary electrophoresis (CE)-based STR typing, while long established as the gold standard, is constrained by limited allele resolution and multiplexing capacity—unable to resolve variation within length-identical alleles or to simultaneously capture autosomal, X-, and Y-chromo...

West Asian Art in the Murals of Zhang Shiqing’s Tomb: Cultural Selection and Visual Representation in the Context of Local Adaptation

The Liao Dynasty culture among the northern nomadic peoples absorbed profound West Asian historical heritage and uniquely ingenious artistic essence to enrich its own diversity. These mural paintings of Liao tombs most concentratedly reflect this phenomenon. As a visual medium fo...

18F-FDG PET/CT in idiopathic retroperitoneal fibrosis with predominant presacral involvement

Idiopathic retroperitoneal fibrosis (IRF) is a rare fibro-inflammatory disease that is often diagnosed only after the development of complications, making early recognition and long-term management challenging. 18 F-FDG PET/CT provides both anatomical and functional information,...

From Agreement to Replacement: Adjudicating a Discordant Fistula Finding

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

A dual GLP-1/GIP agonist inhibits oxidative stress in diabetic rats with cerebral ischemia-reperfusion injury by activating the Nrf2/ARE signaling pathway

Stroke is the leading cause of disability-affected life years in China, posing a great social hazard. Diabetes is a chronic disease that seriously affects human health that can aggravate cerebral ischemia - reperfusion injury. Oxidative stress is the main mechanism through which...