RWTH Aachen University

Early definitive fracture fixation (EDFF) does not alter circulatory neutrophil activation status in physiologically restored polytrauma: a 72-h porcine observation study

Abstract Dysregulation of the cellular innate immune system, particularly involving leukocytes and mainly neutrophils, underlies post-traumatic inflammatory complications. Early definitive fracture fixation (EDFF) triggers immune activation and may exacerbate inflammatory complic...

The Impact of Mindfulness as a Session‐Introduction on Symptoms and Alliance in Individual Cognitive‐Behavioral Therapy With Children and Adolescents: A Randomized Controlled Trial

ABSTRACT Objectives Mindfulness is increasingly being implemented in child and adolescent therapy. However, little is known about its effectiveness in individual settings within a clinical outpatient context. We investigated the effects of session‐introducing mindfulness interven...

Advancing electrochemical measurements of the hydrogen diffusion, solubility, and permeability in polymers

In hydrogen technologies, polymers play a key role due to their chemical corrosion-resistance and mechanical robustness. Yet, reported data characterizing hydrogen permeation in polymers are scarce. In this work, the methodology for electrochemical measurements of hydrogen permea...

Thinking big in small scale: characterization of peroxidase production in Komagataella phaffii using two-compartment scale-down system

Abstract The replacement of cobalt-based siccatives in unsaturated polyester resin curing requires sustainable and scalable biocatalytic alternatives, with fungal peroxidases representing a promising option. For industrial implementation, however, robust large-scale production pr...

Stereotypes about tourette syndrome and associations with social media use: results from a large-scale german population survey

Abstract Misunderstandings about tic disorders are common in both the media and the genreal public. However, no large-scale population-based study has investigated public knowledge and stereotypes about tic disorders. We conducted such a survey about knowledge and stereotypes abo...

Pediatric intensive care follow-up in Germany is rarely established and highly heterogeneous: a nationwide survey of 20 PICUs

BACKGROUND: Survival after pediatric critical illness has improved substantially, but many survivors and their families experience long-term physical, neurocognitive, psychological and social sequelae, summarized as post-intensive care syndrome in pediatrics and in families. Stru...

Adhesion-Promoting Properties of Plasma Polymer Layers in Epoxy Resin for Glass Fiber-Reinforced Plastics

Glass fiber-reinforced plastics (GFRPs) rely on strong fiber–matrix adhesion to achieve optimal mechanical performance. However, conventional sizing systems provide only partial surface coverage and may limit interfacial bonding. The current study investigates atmospheric-pressur...

Learning to bin: differentiable and Bayesian optimization for multi-dimensional discriminants in high-energy physics

Abstract Categorizing events using discriminant observables is central to many high-energy physics analyses. Yet, bin boundaries are often chosen manually. A simple, popular choice in multi-classification tasks is to assign events according to the largest per-class score (“argmax...

Optimization of Material and Printing Parameter Selection for FDM 3D-Printed Bone Models for Osteotomy Training: A Biomechanical and User-Based Evaluation

Although additive manufacturing enables cost-effective surgical training models, variation in materials and printing parameters limits standardization. This study combined biomechanical testing and user evaluation to identify fused deposition modeling (FDM) settings for osteotomy...

Beyond benchmarking: an expert-guided consensus approach to spatially aware clustering

Spatial omics technologies have revolutionized the study of tissue architecture and cellular heterogeneity by integrating molecular profiles with spatial localization. In spatially resolved transcriptomics, delineating higher-order anatomical structures is critical for understand...

Impact of Menopause and Menopausal Hormone Therapy on Liver–Kidney–Metabolic Health

Menopause is associated with unfavorable metabolic changes that may contribute to the development of metabolic dysfunction-associated steatotic liver disease (MASLD), chronic kidney disease (CKD), and increased cardiometabolic risk. Within the evolving cardiovascular-kidney-metab...

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS....

Hidden barriers of education and artificial intelligence: rethinking equity, affordances and ability

Purpose This article investigates how artificial intelligence (AI) reshapes digital inequality in education by introducing the concepts of the AI divide and ability divide. It examines how exclusion emerges not only from unequal access or skills but from differential capacities t...

Toward Material‐Specific Peptides From in Silico Guided Peptide Engineering to Target PET in the Presence of PS

ABSTRACT Synthetic polymers are indispensable but pose major recycling challenges, particularly in mixed plastic waste streams. Enzymatic recycling offers a promising route to specific polymer depolymerization into oligomers and monomers. This requires controlling molecular recog...

Bilateral internal carotid artery dissection and occlusion in Eagle syndrome treated with emergency single-session bilateral carotid artery stenting: a case report

Eagle syndrome (stylocarotid variant) is a rare but potentially life-threatening cause of internal carotid artery (ICA) dissection and ischemic stroke. Bilateral ICA dissection due to Eagle syndrome has been treated with both staged and single-session bilateral carotid stenting e...

A simultaneous approach for training neural differential-algebraic systems of equations

Abstract Neural differential-algebraic systems of equations (DAEs) are a modeling paradigm where some unknown relationships within a DAE are modeled with a neural network and learned from data. Training neural DAEs is more challenging than training neural ordinary-differential eq...

Robust design of multi-energy systems accounting for mixed-integer operational problems

Identifying robust designs for multi-energy systems is computationally challenging. As rigorous approaches are often computationally intractable, heuristics are employed to generate candidate designs. Specifically, we consider a heuristic that iteratively identifies and adds extr...

Longitudinal progression, metrics, age-dependence, and modifiers of ataxia severity in SCA27B: a multicentre study of 219 patients

Background Spinocerebellar Ataxia 27B (SCA27B) is a novel, frequent and likely treatable late-onset autosomal-dominant ataxia caused by GAA repeat-expansions in FGF14 . For understanding disease evolution and imminent trial planning, metrics of the most widely used clinical outco...

DifferentiableThermodynamic Phase-Equilibria forMachine Learning

Abstract Accurate prediction of phase equilibria remains a central challenge in chemical engineering. Physics-consistent machine learning methods that incorporate thermodynamic structure into neural networks have recently shown strong performance for activity-coefficient modeling...

Reliability challenges for resistive random-access memory-based parallel logic computing

<title>Abstract</title> Conventional computing architectures are reaching their scalability limits, while their energy demands increase rapidly. A bottleneck is the separation of memory and processing units, which requires a continuous data transfer. This memory wall increases th...