RWTH Aachen University

Development of a monoclonal antibody targeting the calcification blocking factor CBF

Chronic kidney disease (CKD) patients suffer from a multitude of comorbidities, with vascular calcification being a major one. Recently, a new 19 amino acid long peptide, called calcification blocking factor (CBF), inhibiting vascular calcification has been identified. CBF concen...

Percolation‐Driven β ‐Relaxation Enables Resonant Acceleration of Crystallization in Amorphous Phase‐Change Materials

ABSTRACT Amorphous phase‐change materials enable fast and reversible switching in optical and electronic devices, yet crystallization kinetics are still controlled primarily through empirical thermal protocols. Here we identify a microscopic picture governing crystallization in t...

Construction methods for space-filling heterogeneous topological interlocking assemblies

Deforming fundamental domains of wallpaper groups provides a systematic way to generate non-convex blocks which admit topological interlocking assemblies (TIAs). We use this approach to construct TIAs that fully occupy the space between two parallel planes and incorporate multipl...

Grain boundary complexions stabilize Mg3Sb2-based thermoelectric devices with superior performance

Grain boundary complexions stabilize Mg 3 Sb 2 -based thermoelectric devices with superior performanceGraphical abstract Highlights • Ga-rich grain boundary complexions block Mg-diffusion channels • Mg 3 Sb 2 materials stabilize at 718 K for over 80 h• Single-leg device shows 13....

Decoding the autotetraploid origin of the stress-tolerant wild beet Beta corolliflora

Abstract Background Most crop plants, including sugar beet ( Beta vulgaris subsp. vulgaris ), suffer from domestication bottlenecks and low genetic diversity caused by extensive selection for few traits. However, crop wild relatives (CWRs) harbour useful traits relevant for crop...

Submultiplicative polynomials in combinatorics

Abstract For normalized sequences $$\left( g(n)\right) _{n\in \mathbb {N}}$$ g ( n ) n ∈ N we consider recursively defined polynomials $$P_n^g(x)$$ P n g ( x ) . In this paper we study their submultiplicative property, viewed as a Bessenrodt–Ono type inequality for the partition...

Supporting AI Readiness Through Digital Workflows in Materials Science

Materials science produces heterogeneous data across experiments, simulations, and industrial processes that often remain bound to local formats, manual procedures, and project‐specific software. Digital workflows address this fragmentation through explicit, repeatable, and machi...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Mechanical Characterization of Cervical Spinal Cord Tissue Under Varied Environmental Conditions

ABSTRACT Identifying material parameters for cervical spinal cord tissue requires an understanding of how testing protocols affect the measured response. We use ovine cervical spinal cord white matter to examine the effects of hydration, temperature, adhesive fixation and repeate...

Wafer‐Scale Top‐Down Patterning of Metal Halide Perovskites

ABSTRACT Metal halide perovskites (MHPs) are promising semiconductor materials for next‐generation integrated photonics and electronics because they can be deposited from solution at low temperatures, enabling their monolithic integration with conventional semiconductor substrate...

Identification of a Conserved Temporal Molecular Response Signature to CDK4/6 Inhibition Through Multi-Omics Integration Across Cancer Cell Lines

Treatment of metastatic breast cancer with CDK4/6 inhibitors in combination with hormone ablation is the current first-line standard of care for this indication, and the therapeutic activity of these inhibitors has been demonstrated in various tumor entities. However, the efficac...

Selective dependency of CALR-mutant myeloproliferative neoplasms on TYK2 signaling

Abstract Myeloproliferative neoplasms (MPN) are driven by the oncoproteins JAK2V617F, mutant calreticulin (CALR), and mutant thrombopoietin receptor (TPOR; MPL), all of which activate JAK/STAT signaling. While JAK2 signaling is engaged in all MPNs, TYK2 is dispensable for JAK2V61...

2D theoretically twistable material database

The study of twisted two-dimensional (2D) materials, in which twisting layers create moiré superlattices, has created opportunities for investigating topological phases and strongly correlated physics. The broader potential of a seemingly infinite set of twistable 2D materials re...

Microgels Enable iPSCs to Assemble, Expand, and Differentiate Into Organoids—From Sizable to High‐Throughput

Organoid research holds tremendous potential for personalized medicine and drug development. However, current limitations include reproducibility issues largely due to the use of biologically derived materials, which are prone to batch-to-batch variations. Here, we report a chemi...

Software and Systems Modeling journal celebrates its silver anniversary-a look into the future of modeling

Abstract SoSyM has turned 25. You can even see that on the cover of this dedicated issue. The 25th anniversary of Software and Systems Modeling provides an opportunity to look back—not only at the development of our journal, but also at the evolution of the entire scientific fiel...

Mind the Trust Gap: Identifying (Mis)alignments in Teacher-Student Views Toward Control and Agency in K-12 Classroom AI

As Artificial Intelligence (AI)-based technologies have been integrated into school classrooms where multiple stakeholders (with different roles) interact with each other, it is critical to deeply understand stakeholder views in the classroom. In particular, prior work has not fu...

Flexibility in adsorption-based direct air capture: drivers, mechanisms, and research needs

Direct Air Capture (DAC) is key for net-zero goals, but its high energy demand and costs prevent large-scale deployment. Leveraging time-varying external drivers — renewables availability, electricity prices, ambient conditions, and downstream CO 2 demand — offers a promising pat...

Bryne: sustainable prototyping of finite element models

Abstract Open-source simulation frameworks are evolving rapidly to provide accessible tools for the numerical solution of partial differential equations. Modern finite element (FEM) software such as FEniCS, Firedrake, or DUNE-FEM alleviates the need for modelers to recode the dis...

FAIR Chemistry Data: An Adoptable and Easy-to-Use Workshop Concept for RDM Training

This poster presentation and the associated abstracts belong to the "Fellowship of the Data — International RDM Community Meeting 2026" (datafellows.univie.ac.at/) taking place in Vienna on September 21 and 22, 2026, and to the "Data Stewardship in Germany Community Meeting 2026"...

FAIR Chemistry Data: An Adoptable and Easy-to-Use Workshop Concept for RDM Training

This poster presentation and the associated abstracts belong to the "Fellowship of the Data — International RDM Community Meeting 2026" (datafellows.univie.ac.at/) taking place in Vienna on September 21 and 22, 2026, and to the "Data Stewardship in Germany Community Meeting 2026"...