RWTH Aachen University

What can we learn on ALS pathophysiology from iPSC-derived motor neurons harbouring TARBDP mutations: a systematic review

The degenerating motor neurons of amyotrophic lateral sclerosis (ALS) patients are characterized by the accumulation of cytoplasmic aggregates, specifically enriched in ubiquitinated TDP-43. Expressed mainly in the nucleus and partially in the cytoplasm to execute its role in RNA...

Borosulfates Hosting Se 4 2+ Ions—Crystal Structures, Chemical Bonding, Optical Spectroscopy, and Magnetism

ABSTRACT Despite consistent growth in the number of compounds known to host homo‐ and hetero polycations of group 16 elements, only two, Se 4 [HS 2 O 7 ] 2 and Se 4 [S 4 O 13 ], provided an exclusively oxidic coordination environment, the former being the first structural charact...

A Descriptor for Non‐Arrhenius Ion Transport Enables Design of Sulfide Superionic Conductors

ABSTRACT Non‐Arrhenius ion transport is increasingly observed in solid electrolytes but remains difficult to compare across materials or use in screening. A curated database of 867 conductivity‐temperature entries from thio‐LISICON and LGPS‐type sulfides is used to introduce Meye...

A Descriptor for Non‐Arrhenius Ion Transport Enables Design of Sulfide Superionic Conductors

ABSTRACT Non‐Arrhenius ion transport is increasingly observed in solid electrolytes but remains difficult to compare across materials or use in screening. A curated database of 867 conductivity‐temperature entries from thio‐LISICON and LGPS‐type sulfides is used to introduce Meye...

Classification of recurrence status after surgical treatment of chronic subdural hemorrhage – A machine learning approach

Background Chronic subdural hematoma (cSDH) recurrence requiring reoperation occurs in 5–33% of cases. Predicting recurrence could enable risk-stratified surveillance, reducing imaging in low-risk patients while maintaining monitoring for high-risk individuals. We evaluated wheth...

Remote intestinal changes following blast-induced thoracic trauma with transient hemorrhagic shock and hind-limb ischemia

Abstract Background The intestine is both a driver and a target of posttraumatic organ dysfunction. However, it remains unclear whether, and to what extent an extra-abdominal trauma, such as thoracic trauma with transient hemorrhagic shock and hind-limb ischemia (THS), provokes r...

Strong Converse Exponent of Channel Interconversion

Abstract In their seminal work, Bennett et al. [1] showed that, with sufficient shared randomness, one noisy channel can simulate another at a rate equal to the ratio of their capacities. We establish that when coding above this channel interconversion capacity, the exact strong...

Genolator enables protein function interpretation using a multimodal large language model fusing genomic and structural interpretation with natural language interaction

Abstract Background Decoding the genetic code to unveil its genome functionality is a monumental task which would greatly advance the understanding of disease mechanisms and development of targeted treatments. Although large language models (LLMs) have transformed natural languag...

Context-dependent siderophore exploitability shapes microbial community structure

Siderophores are classically viewed as shared iron-scavenging public goods, yet their ecological roles in multispecies communities remain incompletely understood. Here, we establish a synthetic microbial community to dissect how different siderophores, their uptake compatibility...

Case study of a site-specific design and operation optimization of a wind farm co-located PEM electrolyzer and BESS including degradation

The expansion of volatile renewable energy sources leads to increased electricity price volatility and cannibalization effects, intensifying the economic pressure on project developers. Decentralized hybrid energy systems for renewable hydrogen production offer a solution to expl...

Annual Research Review: Sex differences in conduct disorder – revisiting existing evidence and exploring future directions

Conduct disorder (CD) is a common psychiatric disorder in youth, characterized by severe and recurrent aggressive and antisocial behaviors and associated with substantial healthcare and societal costs. Rates of CD increase during adolescence in both sexes, with the male‐to‐female...

Parvovirus B19 infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity

Summary In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections b...

Enhanced coupling efficiency in geometric terahertz rectennas based on scalable CVD graphene

Ubiquitous electromagnetic radiation from wireless communication networks is an untapped energy source for low-power devices. Passive rectennas (a combination of a rectifier and an antenna) can harvest this energy to power devices and systems, such as autonomous sensors. Rectenna...

Diorganotelluride···N Chalcogen Bonds: Analysis and Tuning of Two σ‐Holes

Organotellurium(II) compounds contain two σ‐holes that may be fine‐tuned through substituents. This work investigates the structural chemistry of two new chalcogen bond (ChB) aggregates of organotellurium(II) compounds and the strong bases 1,4‐diazabicyclo[2.2.2]octane (DABCO) an...

The impact of dimensionality on the stability of node embeddings

Abstract Previous work has shown that node embedding methods can produce different representations and downstream predictions across repeated training runs, even when trained on the same data with identical hyperparameters. However, the role of embedding dimensionality in this in...

Toward the Rational Design of Molecular Field-Coupled Nanocomputing Candidates

Abstract Molecular Field-Coupled Nanocomputing (MolFCN) is a promising beyond-CMOS paradigm in which information is propagated electrostatically rather than through charge transport, enabling ultra-low-power logic. However, identifying molecules with stable logic states and relia...

From Data Lake to Data Mesh. Implementing Distributed Research Data Management in CRC1382

Collaborative Research Centers (CRCs) generate large volumes of heterogeneous research data across multiple projects and disciplines. CRC1382 "Gut-Liver Axis" comprises 22 projects organized into three project areas (A, B, and Q), each contributing complementary perspectives on t...

Coronary artery calcification score as a prognostic factor in patients undergoing allogeneic stem cell transplantation – a retrospective analysis

Abstract Background Coronary artery calcification (CAC) scoring can be measured as a by-product of computed tomography (CT). CAC scoring reflects the general cardiovascular risk profile of patients. The aim of the present study was to determine the prognostic role of CAC on overa...

Host Response Impairs Tissue Integration of a Fibrin Hydrogel Scaffold Containing Poly(ε-caprolactone) Nanofibers for Peripheral Nerve Repair

The development of bioengineered conduits for the repair of large peripheral nerve defects remains challenging. Here, we introduce a biomimetic fibrin hydrogel scaffold containing stacked arrays of aligned poly(ε-caprolactone) (PCL) nanofibers that mimics the naturally forming fi...

Diffusion Kinetics of Ba Cations in Perovskite BaTiO3: A Combined Tracer Diffusion and Metadynamics Study

Abstract Tracer diffusion experiments and metadynamics (MetaD) simulations were used to study the diffusion of Ba cations in the cubic phase of the perovskite oxide BaTiO3. 130BaTiO3 thin films were used as diffusion sources to introduce barium tracer diffusion profiles into sing...