Radboud University Nijmegen

Linking nasopharyngeal and oropharyngeal microbiota to immune responses during influenza-like illness in an aging population

Older adults are vulnerable to influenza-like illness (ILI). To study how infection shapes the respiratory microbiota, we profiled nasopharyngeal (NP) and oropharyngeal (OP) communities alongside local immune mediators in adults aged 60–88, comparing asymptomatic, ILI, and recove...

Self-reported memory strategy use following acquired brain injury

INTRODUCTION: Neuropsychological rehabilitation following acquired brain injury (ABI) often involves interventions teaching individuals with ABI strategies to compensate for memory impairment. However, little is known about spontaneous memory strategy use (i.e. without treatment)...

Implementation of a Guideline-Based Preference Elicitation Tool to Enhance Shared Decision-Making in Supervised Exercise Therapy for Patients With Intermittent Claudication: A Multi-Methods Cluster Randomized Trial

Abstract Importance Shared decision-making is not yet common practice in physical therapy, emphasizing the need for effective decision aids. A preference elicitation tool (PE-tool) was designed to complement supervised exercise therapy (SET) in intermittent claudication treatment...

Airflows redefine the cost of aerial transport in the wild

Fuel economy matters to both animals and machines, as the cost of transport can determine where, when, and how far locomotion is possible. However, established estimates of these values for animal flight come from laboratories and treat the atmosphere as constant, even though fre...

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

Hemocytometric Parameters Associated with Bacterial and Viral Etiology in COPD Exacerbations: An Exploratory Analysis

Exacerbations of Chronic Obstructive Pulmonary Disease (ECOPD) are often triggered by bacterial and viral infections, yet current diagnostic methods are time-consuming and biomarkers (e.g. C-reactive protein (CRP)) show limited accuracy in differentiating between these triggers....

Investigating the transfer of physical stimuli to the dreamed body: A comparative study of muscular, vestibular, and haptic stimulation on dream incorporation

The relationship between the dreamed body and the physical body remains an open question in sleep and dream research. This study examined whether somatosensory stimulation applied during REM sleep modulates the corresponding dream content under controlled conditions. Using a with...

Health-related interpretation of human biomonitoring results – new and updated human biomonitoring guidance values from PARC and HBM4EU

During the first three years of the Partnership for the Assessment of Risks from Chemicals (PARC), we derived health-based human biomonitoring guidance values (HBM-GVs) for 11 substances to enable the direct health-related interpretation of human biomonitoring (HBM) results. HBM-...

The environmental republic: why citizens will save the world

The best and most influential books in social, political or environmental thought are not dry, detailed academic treatises but lively statements of innovative, for some provocative, visions for the...

Natural History of Rare Tumor Risk Syndromes: A Scoping Review to Inform Cost-Effectiveness Models

Background Hereditary cancer syndromes account for approximately 10% of all cancers. Many of these, classified as rare tumor risk syndromes (RTRS), lack comprehensive data on natural history, lifetime cancer risk, and the long-term impact of surveillance. These evidence gaps limi...

Renal trauma in a pediatric Level 1 trauma center: morbidity, mortality, and the role of renal scintigraphy

Abstract Purpose Pediatric renal trauma is uncommon but potentially serious, and is often managed conservatively. Complications may occur, and the clinical value of renal scintigraphy during follow-up remains unclear. This study aimed to assess morbidity and mortality after pedia...

Investigating the role of pragmatic visual signals in language emergence using communication games and agent-based models

Abstract Studying the emergence of language has often relied on communication games and agent-based models, with a strong focus on referential linguistic signals, often overlooking pragmatic signals that are frequently expressed visually, such as facial signals. These signals are...

Anxiety state-related task disengagement varies with trait anxiety

Cognitively demanding tasks are often perceived as costly, leading to effort avoidance, particularly in populations with motivational impairments. Research on anxiety and cognitive effort are mixed: some suggest anxiety increases effort cost, while others indicate it can motivate...

Efficient and robust control with spikes that constrain free energy

Animal brains exhibit remarkable efficiency in perception and action, while being robust to both external and internal perturbations. The means by which brains accomplish this remains, for now, poorly understood, hindering our understanding of animal and human cognition, as well...

Impacting Rare Diseases Healthcare by Case‐Based Telelearning: Description of the Dutch Pilot Metabolic Diseases ECHO

ABSTRACT Inherited metabolic diseases (IMDs) are individually (ultra)rare but collectively relatively common. The Extension for Community Healthcare Outcomes (ECHO) model has been used worldwide since 2003 to disseminate knowledge and best practices in chronic diseases. In 2024,...

Dynamic Observation of Lacy Pattern Formation in a Bone Tissue Model Using Liquid Phase Scanning Transmission Electron Microscopy

ABSTRACT Bone is a hierarchical composite in which carbonated hydroxyapatite platelets form a continuous mineral network within and between collagen fibrils. Although the nanoscale organization of mature bone is well characterized, how mineral precursors transform into this archi...

Ultrasound- and fluoroscopy-guided hip aspiration before revision total hip arthroplasty: procedural outcomes and diagnostic accuracy in sequential cohorts

BACKGROUND AND PURPOSE: Hip aspiration remains essential in the diagnostic work-up of a painful total hip arthroplasty (THA) to assess for periprosthetic joint infection (PJI). In 2020, our institution transitioned from fluoroscopy-guided to ultrasound-guided aspiration. Our stud...

Immunohistochemistry for c-MET, HLA class II, and CD68 does not show prognostic value in early-stage classic Hodgkin lymphoma patients in the EORTC-GELA H9 intergroup randomised trial

Background In classic Hodgkin lymphoma (cHL), identifying high-risk patients is crucial for tailored treatment. Clinical risk factors are useful, but there is room for improvement. Although many diagnostic tissue-based biomarkers have been described to correlate with prognosis, n...

Different lenses on human-AI collaboration: towards a comprehensive view on hybrid intelligence in education

This paper aims to deepen our understanding of hybrid intelligence in education by investigating human-AI collaboration in four real-world educational use cases. We argue against the simple view of automation and augmentation as distinct processes and foreground the automation-au...

Evolution of dipole–dipole dynamics in cold ammonia collisions

Cold polar molecules offer fascinating prospects for ultracold chemistry and quantum physics. However, their inherent collision properties remain largely unknown, as it seems fundamentally impossible to reach sufficiently low energies by merging two beams of molecules with substa...