Radboud University Nijmegen

Recent progress in emerging therapeutics and evaluation of oculopharyngeal muscular dystrophy

PURPOSE OF REVIEW: Oculopharyngeal muscular dystrophy (OPMD) is a late-onset, genetic, neuromuscular disorder causing progressive ptosis, dysphagia and proximal muscle weakness. This review highlights emerging therapeutic strategies and recent advances in understanding the clinic...

A roadmap for standardization of serum albumin measurements

Abstract Albumin measurements in serum have important diagnostic and prognostic roles. However, non-standardized measurement procedures are still used in medical laboratories. An agreed approach for the implementation of metrological traceability to the International System of Un...

The future of high-dose, high-intensity neurorehabilitation: Consensus-based core recommendations from the fourth Stroke Recovery and Rehabilitation Roundtable

Objective: Convergent evidence indicates that high-dose, high-intensity rehabilitation (HDHI) improves outcomes beyond usual care after stroke, yet implementation remains limited. While questions of optimal dose, timing, and delivery format continue to be refined, the biological...

P1.157. International Comparison of Clinicopathologic Characteristics and Outcomes After Minimally Invasive transCervical Esophagectomy (MICE): A Retrospective Cohort Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Minimally Invasive transCervical Esophagectomy (MICE) avoids a thoracic approach via transcervical mediastinal and abdominal dissection. Preserving pleural integrity may reduce pulmonary complica...

When networking pays unequally: proactive personality, gender and career satisfaction in Vietnam and the United States

Purpose This study investigates how proactive personality shapes employees’ career networking and career satisfaction across two national contexts and whether the career returns to networking differ by gender. Drawing on the social role theory, we argue that proactive employees a...

Endotracheal intubation practices, success rates and adverse events in four Dutch emergency departments: a multicentre retrospective study

Endotracheal intubation in the emergency department (ED) is a high-risk intervention associated with significant complications. Contemporary European data on emergency airway management remain limited, and no published data are available from the Netherlands. This study aimed to...

Between-session chasing via time of return in online eCasino gambling

Abstract Background and aims Chasing refers to continuing and/or intensifying gambling following losses (loss-chasing) and/or wins (win-chasing). It is commonly captured between sessions, i.e., returning another day/time after losses or wins in prior sessions. Between-session cha...

Multimodal prehabilitation versus no prehabilitation to improve functional capacity, reduce postoperative complications and improve quality of life in colorectal cancer surgery

OBJECTIVES: This is a protocol for a Cochrane review (intervention). The objectives are as follows: To evaluate the benefits and harms of a multimodal prehabilitation programme versus no prehabilitation with respect to functional capacity, postoperative outcomes, and health-relat...

Parent Mental Health From Preterm Birth Through the NICU Stay

OBJECTIVES: Preterm birth and neonatal intensive care unit (NICU) admission are not only extremely stressful for the infant itself but can also impact parental mental health. This Dutch national prospective cohort study aimed to describe the trajectory of parental mental health f...

Fatal invasive pulmonary aspergillosis caused by Aspergillus texensis: first documented human infection

<title>Abstract</title> Background Invasive Aspergillosis (IA) is a life-threatening infection in immunocompromised patients. Although <italic>Aspergillus fumigatus</italic> predominates, rare and cryptic species are increasingly recognized due to advances in molecular diagnostic...

Antimicrobial stewardship in practice: determinants of prescription behaviour and developing interventions to improve surgical prophylaxis in a Rwandan tertiary hospital—a mixed methods study using the behaviour change wheel

BACKGROUND: Behavioural sciences should be used to design and improve antimicrobial stewardship (AMS) interventions aiming surgical prophylaxis (SP). METHODS: A mixed-methods study at the University Teaching Hospital of Kigali, Rwanda. The study included an audit on SP practices...

Model 1b analytical performance specifications – report on the Prague 2025 workshop

diagnostic medical devices (IVD MD) meet regulatory and quality standards before market release; for external quality assurance assessments; for quality control, monitoring reagent lot-to-lot variability, and allowing preanalytical variation assessments in labs; and for guiding p...

Tiny Droplets, Large Insights: Studying Peptide Aggregationwith Droplet-Based Microfluidics Hyphenated with Ion Mobility MassSpectrometry

Abstract Peptide and protein aggregation are hallmarks of numerous neurodegenerative diseases. However, the structural characterization of oligomeric intermediates remains challenging due to their low abundance, heterogenic nature, and complexity of coinciding and transient react...

Chatbots reduce health-related conspiracy beliefs not because of but despite being perceived as AI

<title>Abstract</title> Beliefs in conspiracy theories and their resistance to correction pose critical challenges to public health. A potential countermeasure to this is the use of Large Language Model (LLM) driven debates about conspiracy theories. Yet while this approach yield...

Using the Stressor-System-Resilience Resources-Outcomes (SSRO) scaffold to clarify the core components of resilience research in medicine

Abstract Modern medicine increasingly extends beyond treating disease to supporting individuals through recovery, adaptation, and long-term functioning, all central to the concept of resilience. Despite growing interest, resilience remains conceptually difficult to structure and...

A Comprehensive Methodology for Estimating Yearly Plastic Pollution Loads in Rivers

Abstract Plastic pollution in freshwater systems represents a major global concern, as rivers serve as critical pathways between land-based sources and marine environments. Yet, inconsistencies are observed between estimated plastic inputs from land and concentrations in the ocea...

Performance Estimation and Ex Vivo Validation of Untethered Magnetic Robots in Soft Tissue

ABSTRACT The navigation and control of untethered magnetic robots (UMRs) within soft brain tissue critically depend on their ability to maintain synchronized rotation under applied rotational magnetic fields. The fundamental upper limit of this magnetic synchronization, known as...

Acceptability and Feasibility of Mindfulness-Based Cognitive Therapy in Adults with Inflammatory Bowel Disease: A Mixed-Methods Study

Abstract Objectives The high psychological burden of inflammatory bowel diseases (IBD) underscores the need for effective and feasible psychological treatment options. This study aimed to explore the acceptability and feasibility of mindfulness-based cognitive therapy (MBCT) for...

GRB 260310A / SN 2026fgk: A Multi-Wavelength Study of a Nearby Underluminous Long GRB and SN with a Complex Afterglow

Abstract We present a comprehensive multi-wavelength study of GRB 260310A / SN 2026fgk, a nearby (z = 0.153), long-duration gamma-ray burst (GRB) with an exceptionally underluminous prompt γ-ray emission and a Comptonized spectrum. The burst occurred at the edge of a blue host ga...

Biosynthesis and Genetic Tuning of Guanine Crystals via Metabolic Engineering of Yeast

ABSTRACT Purine crystals, such as guanine, generate diverse optical phenomena in animals and function as important nitrogen‐storage reservoirs in microalgae. Here, we demonstrate the formation of guanine crystals in Brewer's yeast. Whilst guanine crystals do not naturally contrib...