Peking University

Light‐Absorbing‐Layer‐Free Flash Lamp Annealing for High‐Throughput Fabrication of All‐Solution‐Processed Oxide Electronics

ABSTRACT Metal oxides exhibit high transparency across the visible spectrum, making them challenging to anneal via flash lamp annealing (FLA). Whether such materials can effectively absorb light and self‐heat remains debated. Conventional workarounds often involve light‐absorbing...

Isomer Effect of Double-Spiro Mechanophores in Polymer Mechanochemistry

Abstract Easy construction of rhodamine spiro rings and diversity of naphthalenediol enable various isomers of the naphthalene-fused double rhodamine structure and provide the possibility to study the structure–performance relationship of double-spiro mechanophores. Herein, we fo...

Discovery of a novel MurA inhibitor via AlphaFold 3 model-based virtual screening

S. aureus is one of the most important bacteria associated with human diseases. UDP-N-acetylglucosamine 1-carboxyethylene transferase (MurA) is an important enzyme involved in the synthesis of peptidoglycan in bacterial cell walls. The crystal structure of MurA from S. aureus has...

Plant-derived exosome-like nanovesicles alleviate testicular injury by suppressing p21-mediated cell cycle arrest in Sertoli cells

Testicular dysfunction represents a leading cause of male infertility, yet effective therapeutic interventions remain elusive. Here, we report a novel plant-derived nanotherapeutic strategy for testicular injury using Cistanche deserticola -derived exosome-like nanovesicles (CDEL...

Development of a deep learning model for detecting and measuring gallstones on computed tomography images

PURPOSE: To develop a deep learning model for the automated detection and measurement of gallstones on non-contrast CT images. METHODS: A total of 3,231 CT scans were retrospectively enrolled as an internal cohort, while 753 CT scans from the public AMOS (Abdominal Multi-Organ Se...

Hyper-spectral photonic integrated circuits based on recursive inverse design

Manipulating optical spectra with complex spectral responses is central to high-performance photonic computing and sensing, but conventional integrated circuits typically increase features by cascading devices, which scales complexity linearly with cascade depth and is difficult...

Low Dasatinib Penetration of the Blood–Brain Barrier in Children With Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia: Evidence From LC‐MS/MS Analysis

ABSTRACT We measured dasatinib concentrations in paired plasma and cerebrospinal fluid (CSF) samples from children with Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL). Blood samples were collected from children at 0 h (pre‐dasatinib) and 2 h post‐dasatini...

Hepatocyte-intrinsic ER stress and NRF2 initiate primary sclerosing cholangitis, providing therapeutic insights

primary sclerosing cholangitis (PSC) is a severe liver disease that can progress to cholangiocarcinoma. Therapeutic development has been hindered by the rarity of PSC and by its poorly understood origin, which reflects incompletely defined genetic and environmental risk factors....

Environmental exposure to semi-volatile organic compounds and COPD progression: Evidence mapping, exposure assessment and metabolomic insights

Introduction Chronic obstructive pulmonary disease (COPD) progression may be influenced by non-smoking environmental exposures, especially among never-smokers and environmentally exposed populations. Semi-volatile organic compounds (SVOCs) are relevant because they persist in air...

Small-molecule cocktail 2SM promotes heart regeneration via inducing embryonic-like cardiomyocyte state

Adult mammalian cardiomyocytes exhibit limited regenerative capacity, which remains a major challenge for functional recovery after myocardial infarction (MI). Our previous study identified a cocktail of five small molecules (5SM) that promotes cardiomyocyte proliferation and hea...

Concordance of genetic determinants of acute coronary artery disease between European and Chinese populations

AIMS: This study examined the concordance of associations of single nucleotide polymorphisms (SNPs) for acute coronary artery disease (CAD) discovered in Europeans with acute CAD, chronic ischaemic heart disease (IHD) or stroke in Chinese adults. METHODS: In a nested case-control...

Carbohydrate food structure before sugar dose in metabolic ageing after hypertension or diabetes

Hypertension and diabetes make large populations candidates for dietary counseling, yet carbohydrate advice is often narrowed to reducing sugar intake. This study asked whether carbohydrate food structure should be assessed before sugar dose using biological ageing and renal risk...

China’s Policy Responses to High Oil Prices: Balancing Macroeconomic Stability and Low-Carbon Transition

International oil price volatility poses severe risks to macroeconomic stability and energy security, presenting complex policy challenges for China as it simultaneously pursues economic growth and a low-carbon transition. To bridge the gap between general equilibrium reallocatio...

Beyond cholesterol: targeting ceramide signaling in cardiorenal metabolic crosstalk

Cardiovascular-Kidney-Metabolic (CKM) syndrome is associated with increased risks of cardiovascular mortality and target organ failure. Despite optimal lipid-lowering therapies, patients remain at substantial residual risk for adverse cardio-renal outcomes. Conventional cholester...

From predictive model to clinical application: interpretable prediction of metachronous liver metastasis in colorectal cancer

Metachronous liver metastasis (MLM) after curative surgery is a major determinant of poor prognosis in colorectal cancer (CRC), yet existing approaches based on clinicopathological indicators or imaging alone have limited predictive performance and clinical applicability. This re...

Estimating individualized gonadotropin starting doses in women with PCOS: a target-driven machine learning model for GnRH-antagonist stimulation

Abstract Background Women with polycystic ovary syndrome (PCOS) are prone to excessive ovarian response and ovarian hyperstimulation syndrome (OHSS) during controlled ovarian stimulation, whereas overly conservative gonadotropin (Gn) dosing reduces oocyte yield and efficiency. Th...

Suspected donor-vessel ischemia in a collateral-dependent right coronary artery occlusion presenting as a de Winter-like pattern with inferior ST-segment elevation: a case report

The de Winter electrocardiographic pattern is a recognized equivalent of ST-segment elevation myocardial infarction and is most commonly associated with acute left anterior descending artery ischemia. Its coexistence with overt ST-segment elevation in another territory is uncommo...

Post-translational modifications of integrins: molecular mechanisms and pathological implications

Integrins are cell-surface adhesion receptors that mediate bidirectional signaling governing migration, proliferation, and survival. Emerging evidence reveals that integrin function is finely controlled by an interconnected network of post-translational modifications (PTMs), span...

Reliability and diagnostic performance of radiologic indices of the proximal humerus in evaluating bone mineral density: a retrospective study

Proximal humerus fractures (PHFs) are the third most common osteoporotic fractures. Assessment of bone mineral density (BMD) is clinically relevant in patients with PHFs. Several studies have proposed the use of radiologic indices, including the average cortical bone thickness (C...

Incidence and risk factors for rotator cuff retear after arthroscopic rotator cuff repair in middle-aged and older patients: a systematic review and meta-analysis

Abstract Background Rotator cuff retear remains a major challenge after arthroscopic rotator cuff repair (ARCR), particularly among middle-aged and older patients. This study aimed to investigate the incidence of retear and identify its associated risk factors in this patient pop...