Institution
Oregon Health & Science University
Recent research
- Health & Medicine
Importance The treatment of prostate cancer with radiotherapy is evolving. How quickly radiotherapy can be delivered, and the relative risks and benefits of such a treatment, is of significant public interest. Objective To determine whether stereotactic body radiotherapy (SBRT) w...
- Climate & EnvironmentOpen access
Genomic catalogue of giant viruses reveals expanded diversity and functional potential
Nucleocytoplasmic large DNA and Mirusviricota viruses exhibit taxonomic richness which continually expands due to metagenomic sequencing. Here we curate a database of giant virus metagenome-assembled genomes (GVMAGs V2), comprising 8,508 species-level representatives from 18,727...
- Biology
OBJECTIVE To determine whether soluble urokinase plasminogen activator receptor (suPAR) is modified by randomized diabetes and revascularization strategies in patients with type 2 diabetes and coronary artery disease and whether combined suPAR and hs-CRP classification refines re...
- BiologyOpen access
The tumor microenvironment influences treatment response in ER-positive breast cancer, but what distinguishes responders from non-responders and how it changes during treatment is poorly understood. Here, we profiled ER-positive breast tumors treated with neoadjuvant chemotherapy...
- Health & MedicineOpen access
Background: Smoking prevalence among people in substance use treatment is substantially higher than the national average. Residential substance use treatment represents an opportune time to address this disparity. California launched the Tobacco Free for Recovery Initiative to he...
- BiologyOpen access
Abstract The insular cortex integrates interoceptive and exteroceptive information to mediate bodily homeostasis, emotion and learning. However, the cellular and circuit substrates governing insular functions are poorly understood compared to primary cortices. Here we quantify de...
- Health & MedicineOpen access
Youth experiencing homelessness (YEH) are 5–8 times more likely than housed peers to become pregnant. A more nuanced examination of YEH pregnancy desire may better inform pregnancy and pregnancy prevention guidance. This study examined pregnancy ambivalence, pregnancy history, co...
- Health & Medicine
Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest
Importance Therapeutic hypothermia is widely used for neuroprotection following cardiac arrest, but clinical trials have not consistently demonstrated improved neurological outcomes, and the optimal duration of cooling remains uncertain. Objective To determine the duration of the...
- BiologyOpen access
A compendium of next-generation patient-derived models for diverse cancers
Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...
- Society & EconomicsOpen access
Sleep is essential for optimal health as short sleep is associated with cardiovascular disease, diabetes, and early mortality. One-third of adults in the U.S. and Canada do not receive sufficient sleep. Canadian adults are typically healthier than U.S. adults and inequities in sl...
- Health & Medicine
Telemedicine Use in Primary Care for Children: 2019–2024
BACKGROUND AND OBJECTIVES We lack national data on the maturing clinical use of telemedicine (TM) in children’s primary care. This manuscript describes patterns of TM use for problem-based visits overall, across clinical domains, and associations of use with clinic visit volume....
- Health & Medicine
Background One of the defining symptoms of chronic rhinosinusitis is nasal discharge. There are multiple treatment options, and the relative efficacy of each medication on discharge is unclear. Objective To characterize the effects of medical treatment on the various forms of nas...
- Health & MedicineOpen access
Cost-Effectiveness of Endovascular vs Open Surgery for Chronic Limb-Threatening Ischemia
Importance: Choosing between endovascular and open (bypass) surgical revascularization for chronic limb-threatening ischemia has major implications for clinical practice. Objective: To evaluate the cost-effectiveness of endovascular vs bypass surgical revascularization. Design, S...
- Health & Medicine
OBJECTIVE: To evaluate the effect of septorhinoplasty on work productivity and activity impairment. STUDY DESIGN: Prospective cohort. SETTING: Four tertiary institutions. METHODS: Adults undergoing septorhinoplasty were administered surveys preoperatively and 3 to 8 months postop...
- Biology
Plain Language SummaryWhat is this summary about?Transthyretin amyloid cardiomyopathy (ATTR-CM) happens when transthyretin (TTR) protein breaks apart, forming clumps that build up in the heart, making it harder to pump blood.People with ATTR-CM often go to the hospital multiple t...
- Health & Medicine
Autonomous Oxygen Titration for Maintaining Normoxemia in Acutely Ill Adults
Importance For acutely ill adults who are hospitalized with hypoxemia, supplemental oxygen is titrated to maintain normoxemia. In current practice, clinicians intermittently titrate oxygen, potentially exposing patients to hypoxemia and hyperoxemia between assessments. Autonomous...
- Health & Medicine
Purpose The Oversedation Risk Criteria (ORC) is a prediction model that estimates prescription opioid-induced respiratory depression (OIRD) or oversedation risk in hospitalized patients. The study objectives were to estimate OIRD/oversedation risk via the ORC and to determine the...
- Society & EconomicsOpen access
Guns and Perceptions of Safety Among US Women
Importance: Prior research found differences in the perceived safety benefits from firearm exposure among diverse gun owners. More women have bought firearms in recent years, resulting in a growing proportion of women who own guns. Objective: To examine differences in perceptions...