Oregon Health & Science University

Schizophrenia research in 2026: report from the annual meeting of the Schizophrenia International Research Society

Abstract SIRS 2026, held under the theme “Schizophrenia Research in the Era of Artificial Intelligence,” brought together researchers, clinicians, and persons with lived experience to take stock of a field whose tools for measuring, predicting, and intervening in psychosis have e...

Modeling the heterogeneity of cognitive dysfunction in Parkinson’s disease using partially ordered set models

Abstract Traditional binary classifications of Parkinson’s disease (PD) cognitive dysfunction fail to capture its inherent heterogeneity. This study introduces the Partially Ordered Set (POSET) model, a Bayesian framework, to analyze cognitive heterogeneity using Parkinson’s Prec...

Mixed-Method Analysis of a National Survey of Hospitals with Inpatient Hepatitis C Treatment Initiatives

Abstract We surveyed clinicians about efforts to initiate hepatitis C antivirals during hospitalization or at discharge. We identified 29 hospitals in the United States working on such initiatives, with most efforts being less than 3 years old. Further initiative expansion is hin...

Impact of Optical Coherence Tomography Angiography Scan Protocols on Quantitative Microvascular Biomarkers in Diabetic Retinopathy

Purpose: The purpose of this study was to evaluate the influence of optical coherence tomography angiography (OCTA) scan protocols on quantitative measurements of diabetic retinopathy (DR) biomarkers and their diagnostic performance for DR staging. Methods: In this cross-sectiona...

Left Atrial Appendage Closure Versus Oral Anticoagulation for Prevention of Stroke or Systemic Embolism in Patients With Atrial Fibrillation: An Updated Meta‐Analysis of 7004 Patients Across Six Randomized Trials

ABSTRACT Introduction Left atrial appendage closure (LAAC) is an emerging alternative for stroke prevention in patients with atrial fibrillation (AF) who are unsuitable for long‐term oral anticoagulants (OACs). However, its efficacy and safety relative to OACs remain uncertain. M...

Trends in Ophthalmic Hospital Transfers and Consultations Across US Academic Centers

Importance Academic medical centers increasingly serve as a safety net for urgent and complex ophthalmic conditions, yet trends in the demand for hospital-based ophthalmic services remain poorly characterized. Objective To characterize multi-institutional trends in ophthalmology...

Influenza A virus infection induces immune dysregulation in the placenta and fetus without vertical transmission in nonhuman primates

Influenza A virus (IAV) infection during pregnancy is associated with stillbirth and preterm birth. We hypothesized that maternal IAV infection disrupts placental and fetal immune networks in ways that correlate with disease severity. Pregnant pigtail macaques were inoculated wit...

Diabetic Peripheral Neuropathy: Implementing Guidelines into Practice

Diabetic Peripheral Neuropathy (DPN) is a common and debilitating complication of diabetes, affecting up to 50% of patients. Early identification and management of DPN are crucial to minimize complications and maintain patient quality of life. Multiple guidelines have been develo...

Diagnosis and management of transthyretin amyloidosis (ATTRv) across ATTRv-PN and mixed phenotype: an international delphi consensus

Abstract Background Transthyretin amyloidosis is a progressive, potentially fatal genetic disorder primarily associated with polyneuropathy (ATTRv-PN) or cardiomyopathy (ATTR-CM). Disease presentation is heterogenous. Patients often present with a mixed phenotype. Although recent...

Pathways from adverse childhood experiences to parenting competence: the roles of cognitive emotional regulation and social support

These findings suggest that strengthening adaptive CER may be particularly effective for mothers with higher levels of social support. For those with lower levels of social support, the first priority should be enhancing social support to lay the groundwork for emotional regulati...

RINGSIDE Phase II Study of Varegacestat for Treatment of Desmoid Tumors: A Randomized Dose-Finding Clinical Trial

PURPOSE Desmoid tumors (DTs) are rare, often locally aggressive, connective tissue neoplasms with limited effective treatment options. We evaluated the safety and efficacy of varegacestat, an oral gamma-secretase inhibitor. METHODS RINGSIDE phase II was an open-label, randomized,...

Metrology, Standards, and Mission: Synopsis of the 2026 Annual Meeting of the Council on Ionizing Radiation Measurements and Standards (CIRMS)

The Council on Ionizing Radiation Measurements and Standards (CIRMS) is an independent, non-profit council composed of experts from academia, government, and industry across all areas of ionizing radiation science and technology, providing leadership, focus, and coordinated actio...

Intratumoral Immunotherapy—The Future of Treating Merkel Cell Carcinoma?

Merkel cell carcinoma (MCC) represents a rare but highly aggressive neuroendocrine skin cancer with limited systemic therapy options for patients who fail or are ineligible for immune checkpoint inhibitors (ICIs). Intratumoral (IT) immunotherapy has emerged as a promising strateg...

Epigenetic insights into extreme longevity in the world’s oldest terrestrial animal, Jonathan

Aldabra giant tortoises ( Aldabrachelys gigantea ) are exceptionally long-lived. We sequenced the genome and methylome of Jonathan, a 194-year-old Aldabra, to explore the molecular basis of his longevity. Relative to other giant tortoises ( A. gigantea and Chelonoidis abingdonii...

Treating donor human milk with alternative pasteurization methods, high-pressure processing and ultraviolet-C irradiation, and their impact on pathogen inactivation, nutrient content and protein bioactivity: a scoping review

Human milk is a complex bioactive food matrix that supports the growth and development of infants. In the absence of their parent's own milk, hospitalized preterm infants receive Holder pasteurized donor milk (DM). However, Holder pasteurization (HoP; 62.5 °C, 30 min) inactivates...

Weighting of Spectral and Temporal Cues with n-of-m Cochlear Implant Strategies Depends on Voice Pitch

Abstract Purpose The relative contributions of spectral and temporal cues to voice pitch perception in cochlear implant (CI) users remain unclear. This study aimed to directly quantify these contributions in dynamic speech stimuli with clinical n -of- m processors. Methods Fundam...

Brain gray matter changes across chronic pain trajectories: MRI evidence from 35,000 individuals

ABSTRACT: Chronic pain affects brain gray matter structure, but the magnitude, pattern, and reversibility of brain changes upon pain recovery remain unclear because of inconsistent findings from small-scale studies. We analyzed data from 35,052 UK Biobank participants who complet...

Conserved hepatic RNA signatures across multiple cohorts reveal novel mechanistic clues for advanced fibrosis in human MASLD.

BACKGROUND: Fibrosis development in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) is a key indicator of disease progression and clinical outcome. Bulk and single-cell transcriptomics on human tissue have advanced understanding of fibrosis progress...

Spontaneous Resolution Chiari I Malformation in an Adult.

BACKGROUND AND IMPORTANCE: With the wide availability of MRI for brain and cervical spine complaints, adult patients are diagnosed with Chiari I malformation (CMI) frequently. Although there are few reports of spontaneous resolution of CMI in adults, it is important to consider w...

Reading Incivility Through Camp: Moral Binaries in Nursing Education.

In the United States context, incivility in nursing education is widely studied as a behavioral problem to be measured and remedied. In contrast, civility has been conceptualized as a professional virtue that is foundational to nursing identity. Together, these civility and inciv...