Oregon Health & Science University

Beyond “Picky Eating”: Identification, Screening, and Referral for Pediatric Feeding Disorders in Primary Care

Pediatric feeding disorders (PFDs) affect 1 in 37 children under age 5 in the United States, representing a common yet frequently underrecognized condition in primary care. In 2019, a multidisciplinary expert panel established the first consensus definition of PFD, creating a sta...

Gene Silencer Therapy in Transthyretin Amyloid Cardiomyopathy

Importance: Gene-silencing therapies reduce hepatic transthyretin (TTR) production and have been evaluated in phase 3 trials in TTR amyloid cardiomyopathy (ATTR-CM). However, differences in trial design and background therapies have limited assessment of the overall treatment eff...

Abridged Retinal Fluorescence Lifetimes in Glaucoma

This study investigates the relationship between glaucoma and retinal fluorescence lifetimes using FLIO. The results show that participants with glaucoma have shorter mean lifetimes compared to those without glaucoma, even after adjusting for age and diabetes status. The study su...

Effect of Aficamten on Cardiac Structure and Function in Patients with Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Aficamten significantly improved both functional capacity and patient-reported health status in patients with symptomatic nonobstructive hypertrophic cardiomyopathy in the phase 3 randomized, placebo-controlled ACACIA-HCM trial (Assessment Comparing Aficamten to Place...

Abridged Retinal Fluorescence Lifetimes in Glaucoma

This study investigates the relationship between glaucoma and retinal fluorescence lifetimes using FLIO. The results show that participants with glaucoma have shorter mean lifetimes compared to those without glaucoma, even after adjusting for age and diabetes status. The study su...

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...

Global Efficacy of Aficamten in Nonobstructive Hypertrophic Cardiomyopathy: Results From ACACIA-HCM

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (nHCM) is associated with significant morbidity with no approved treatment. Aficamten is a cardiac myosin inhibitor targeting excess contractility and diastolic impairment, the predominant mechanism responsible for adverse ou...

Normative Ranges for Auditory Brainstem Response Wave I Amplitude: A Potential Diagnostic Indicator of Cochlear Deafferentation

PURPOSE: While cochlear synaptopathy has limited impact on auditory thresholds, there is increasing evidence that cochlear deafferentation is associated with auditory perceptual deficits. However, there is currently no means for diagnosing synaptopathy or deafferentation in indiv...

GNL3 SUMOylation is essential for DNA double-strand break repair by homologous recombination

DNA double-strand break (DSB) repair via homologous recombination (HR) is critical for maintaining genomic integrity and requires proper DNA end resection to generate single-stranded DNA (ssDNA) overhangs. However, the mechanisms governing this critical step in cells remains poor...

Variables That Influence Changes in Temporomandibular Joint Structure

ABSTRACT Background There are no objective measures which forecast longitudinal changes in the temporomandibular joint (TMJ). Objective To identify variables that predicted longitudinal changes in TMJ structure. Methods Over an average of 8 years, baseline and follow‐up computed...

Examining the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) Moderate Risk Cannabis Use Threshold Among a Sample of U.S. Military Veterans with Chronic Pain Who Report Medical Cannabis Use

BACKGROUND: The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) is widely used for substance use screening. However, its established risk cutoffs may not be appropriate for people who use cannabis for medical reasons. This study sought to determine an optimal m...

Addressing Common Problems in Autism Research: Cohort Development and Sample Description for a Participatory, Real-World, Longitudinal Study of Outcomes in Autistic Adults

Adult autism services research is plagued by methodological challenges, including difficulty obtaining representative or heterogeneous samples and a frequent mismatch between experimental methodologies and real-world settings. The Academic Autism Spectrum Partnership in Research...

P1.199. Preoperative Frailty Testing for Esophagectomy: Stair-Climb Time as the Strongest Predictor of Major Complications

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Esophageal cancer is increasingly common in an aging population. Esophagectomy remains a cornerstone of treatment but carries substantial perioperative risk. Ac...

Implementation of a pilot online educational program to identify paramagnetic rim lesions

Background: Paramagnetic rim lesions are a highly specific magnetic resonance imaging biomarker for multiple sclerosis now incorporated into the 2024 McDonald Criteria. However, paramagnetic rim lesion identification remains underutilized in clinical practice. This study evaluate...

Management Patterns and Outcomes of Vestibular Schwannoma in Older Adults: Assessment of the SEER Database

OBJECTIVE: Vestibular schwannoma (VS) is a benign intracranial tumor that is increasingly diagnosed in older adults. The relative contributions of tumor burden and surgical management to overall survival in elderly and very elderly patients remain incompletely characterized at a...

Study protocol for first national vasa previa perinatal registry

Vasa previa is a rare but potentially catastrophic obstetric condition characterized by unprotected fetal blood vessels over or adjacent to the internal cervical os. Although advances in prenatal ultrasound have dramatically improved neonatal survival through planned cesarean del...

Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancer

Abstract Background Pancreatic adenocarcinoma (PDAC) is an abysmal disease, with a poor clinical outcome, largely due to limited life-extending treatments for patients. Notoriously, PDAC displays a T cell-suppressive tumor microenvironment where underlying molecular mechanisms th...

Dental Students' Use of Captions and Transcripts: Implications for ADA WCAG 2.1 Compliance

OBJECTIVES: This study examined how Doctor of Dental Medicine (DMD) students use captions and transcripts, their motivations for use, and their perceived learning benefits, with attention to accessibility and upcoming ADA compliance requirements. METHODS: A cross-sectional, anony...

Changes in Emergency Department Pediatric Readiness, Inpatient Services, and Excess Child Deaths

Importance Emergency department (ED) pediatric readiness and pediatric inpatient services have changed over time in many hospitals, but the impact of these changes on pediatric outcomes is unclear. Objective To evaluate pediatric mortality associated with changes to ED pediatric...

Hepatic stellate cell activation in the postpartum liver is consistent with pre-metastatic niche establishment

Postpartum breast cancer (PPBC), diagnosed within 10 years of the last childbirth, has an increased risk of liver metastasis. In murine models, tumor transplant studies reveal that weaning-induced liver involution is a key determinant of breast cancer metastasis to the liver. Her...