Oregon Health & Science University

Epigenetic insights into extreme longevity in the world’s oldest terrestrial animal, Jonathan

Aldabra giant tortoises ( Aldabrachelys gigantea ) are exceptionally long-lived. We sequenced the genome and methylome of Jonathan, a 194-year-old Aldabra, to explore the molecular basis of his longevity. Relative to other giant tortoises ( A. gigantea and Chelonoidis abingdonii...

Metrology, Standards, and Mission: Synopsis of the 2026 Annual Meeting of the Council on Ionizing Radiation Measurements and Standards (CIRMS)

The Council on Ionizing Radiation Measurements and Standards (CIRMS) is an independent, non-profit council composed of experts from academia, government, and industry across all areas of ionizing radiation science and technology, providing leadership, focus, and coordinated actio...

Intratumoral Immunotherapy—The Future of Treating Merkel Cell Carcinoma?

Merkel cell carcinoma (MCC) represents a rare but highly aggressive neuroendocrine skin cancer with limited systemic therapy options for patients who fail or are ineligible for immune checkpoint inhibitors (ICIs). Intratumoral (IT) immunotherapy has emerged as a promising strateg...

Treating donor human milk with alternative pasteurization methods, high-pressure processing and ultraviolet-C irradiation, and their impact on pathogen inactivation, nutrient content and protein bioactivity: a scoping review

Human milk is a complex bioactive food matrix that supports the growth and development of infants. In the absence of their parent's own milk, hospitalized preterm infants receive Holder pasteurized donor milk (DM). However, Holder pasteurization (HoP; 62.5 °C, 30 min) inactivates...

Weighting of Spectral and Temporal Cues with n-of-m Cochlear Implant Strategies Depends on Voice Pitch

Abstract Purpose The relative contributions of spectral and temporal cues to voice pitch perception in cochlear implant (CI) users remain unclear. This study aimed to directly quantify these contributions in dynamic speech stimuli with clinical n -of- m processors. Methods Fundam...

Brain gray matter changes across chronic pain trajectories: MRI evidence from 35,000 individuals

ABSTRACT: Chronic pain affects brain gray matter structure, but the magnitude, pattern, and reversibility of brain changes upon pain recovery remain unclear because of inconsistent findings from small-scale studies. We analyzed data from 35,052 UK Biobank participants who complet...

Reading Incivility Through Camp: Moral Binaries in Nursing Education.

In the United States context, incivility in nursing education is widely studied as a behavioral problem to be measured and remedied. In contrast, civility has been conceptualized as a professional virtue that is foundational to nursing identity. Together, these civility and inciv...

Conserved hepatic RNA signatures across multiple cohorts reveal novel mechanistic clues for advanced fibrosis in human MASLD.

BACKGROUND: Fibrosis development in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) is a key indicator of disease progression and clinical outcome. Bulk and single-cell transcriptomics on human tissue have advanced understanding of fibrosis progress...

Spontaneous Resolution Chiari I Malformation in an Adult.

BACKGROUND AND IMPORTANCE: With the wide availability of MRI for brain and cervical spine complaints, adult patients are diagnosed with Chiari I malformation (CMI) frequently. Although there are few reports of spontaneous resolution of CMI in adults, it is important to consider w...

Convergent validity of measures of daily functioning in older adults

INTRODUCTION: Although information on daily functioning is needed for accurate diagnoses of neurocognitive disorders, little has been published on the psychometric properties of measures of daily functioning. Convergent validity is one such psychometric property that examines the...

The VA HEARS Model for Predicting Audiogram Changes in Adults Undergoing Cisplatin Chemoradiotherapy

Objective: Develop and validate a model for predicting complete audiograms of individual patients that also supports cisplatin-ototoxicity forecasting and early identification using any existing diagnostic and classification criteria. Study design: Prospective observational study...

Synthesising Generative Artificial Intelligence Competency Domains for Medical Education Faculty

ABSTRACT Background Artificial intelligence (AI), including generative AI (GenAI), is reshaping clinical care and medical education, requiring medical education faculty to develop new competencies. As GenAI becomes integrated into clinical and teaching workflows, faculty must gui...

Pooled prevalence of anxiety and depressive symptoms among adults with type 2 diabetes: a systematic review and meta-analysis

Abstract Purpose Anxiety and depressive symptoms are highly prevalent among individuals with type 2 diabetes mellitus (T2DM), yet they remain underdiagnosed despite their substantial impact on health outcomes. In addition to impairing treatment adherence, these conditions may con...

IFNγ-dependent tumor-cell MHC-II is restrained by MAPK signaling and associated with immunotherapy responsiveness in pancreatic ductal adenocarcinoma

Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment (TME) and poor prognosis. Although major histocompatibility complex class II (MHC-II) is typically expressed by professional antigen-presenting cells, its regulation a...

Carbon starvation of Mycobacterium abscessus induces a non-replicating state with extensive proteomic remodeling

ABSTRACT Mycobacterium abscessus ( Mab ) is an opportunistic pathogen that can cause chronic, debilitating lung disease. Mab is intrinsically resistant to most antibiotics, making Mab infections challenging to manage and frequently incurable. During infection, Mab adapts to survi...

Performance and safety of a multi-cancer early detection test: the PATHFINDER 2 study

Abstract Early cancer detection improves survival; however, most cancer types do not have guideline-recommended screening. We previously reported the first PATHFINDER study that established feasibility of cancer screening with a blood-based multi-cancer early detection (MCED) tes...

The PancreaSure Multianalyte Blood Test Performs Well at Distinguishing Early-Stage Pancreatic Ductal Adenocarcinoma from High-Risk Controls: A Retrospective Secondary Analysis

Background/Objectives: Biomarkers that can facilitate early detection of pancreatic cancer and extend patient survival are a significant unmet need. PancreaSure is a serum biomarker signature that performed well at distinguishing Stage I and II pancreatic ductal adenocarcinoma (P...

Polycyclic aromatic hydrocarbons, gut microbiome composition, impulsivity, and attention covary in a human cohort

ABSTRACT Polycyclic aromatic hydrocarbons (PAHs) are pervasive environmental pollutants linked to adverse neurobehavioral outcomes, yet the biological pathways coupling exposure to behavior are poorly defined. The gut microbiome is both sensitive to PAH exposure and a modulator o...

Mifepristone versus other interventions for the prevention of pregnancy in reproductive-age women using emergency contraception

RATIONALE: Emergency contraception uses drugs or intrauterine devices to prevent pregnancy after unprotected intercourse. Understanding the effectiveness, safety, and acceptability of the various methods available is critical for reproductive healthcare providers and their patien...

Fundamentals of Arthroscopic Surgery Training Program Shows Transfer Validity Through Enhanced Operative Arthroscopic Performance

PURPOSE: To evaluate the content, construct, concurrent, and transfer validity of the Fundamentals of Arthroscopic Surgery Training (FAST) program and to determine whether FAST testing performance correlated with arthroscopic performance in the operating room. METHODS: Participan...