National and Kapodistrian University of Athens

Machine Learning-Guided Discovery of Robust Conditions for Photochemical Nickel-Catalyzed Cysteine Arylation

Abstract Late-stage functionalization (LSF) of peptides offers direct access to structurally diverse analogues, but developing general, chemoselective protocols remains challenging due to the complexity of peptide substrates and the vast number of reaction variables. Traditional...

Diabetic retinopathy in patients with latent autoimmune diabetes in adults: a mini-review of the literature

This mini-review gathers the literature regarding the development of diabetic retinopathy (DR) in patients with latent autoimmune diabetes of adults (LADA). PubMed and Scopus databases were searched up to 31st January 2025 for articles examining retinal changes in patients with L...

Mito-nuclear discordance in a genus of darkling beetles (Coleoptera: Tenebrionidae: Dailognatha ) reveals both incomplete lineage sorting and introgression driven by complex island paleogeography

Abstract Phylogenetic studies of insular radiations have traditionally relied on mitochondrial DNA, yet the increasing availability of genomic datasets has revealed numerous cases of phylogenetic discordance between mitochondrial and nuclear markers across animal taxa. The presen...

Moser–Tardos Algorithm with small number of random bits

We study a variant of the parallel Moser–Tardos Algorithm. We prove that if we restrict attention to a class of problems whose dependency graphs have subexponential growth, then the expected total number of random bits used by the algorithm is constant; in particular, it is indep...

Treat (the whole of) me: a systematic review and qualitative meta-ethnographic synthesis of the experiences of women with POP, SUI or mesh complications in the context of surgical treatment

Abstract Background Stress Urinary Incontinence (SUI) and Pelvic Organ Prolapse (POP) are common pelvic floor disorders that may significantly impact women’s quality of life. Surgical interventions are available to treat these conditions, some using synthetic mesh. Whilst most wo...

A Dichotomy of Finite Element Spaces and Its Application to an Energy-Conservative Scheme for the Regularized Long Wave Equation

Abstract. Certain energy-conservative Galerkin discretizations for nonlinear dispersive wave equations have revealed an unusual convergence behavior: optimal convergence is attained when continuous Lagrange finite element spaces of odd polynomial degree are employed, whereas the...

Measurements of the production of W$$^{\pm }$$ and Z$$^0$$ bosons in pp collisions at $$\sqrt{s} = 13$$ TeV

Abstract Measurements of the production of the W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons at midrapidity in pp collisions at $$\sqrt{s} = 13$$ s = 13 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons are detected via their (di)e...

Assessing the role of plan complexity and target geometry through multi‐institutional gel based end‐to‐end QA in multi‐focal single isocenter stereotactic radiosurgery

BACKGROUND: Single-isocenter stereotactic radiosurgery enables efficient treatment of multiple brain metastases (SI-MBM SRS), but demands high geometric accuracy. Plan complexity metrics are increasingly used as indicators for quality assurance (QA) performance, however their app...

Rethinking Salt in Cheese: Advances, Challenges, and Strategies for Sodium Reduction

Sodium chloride (NaCl) is a multifunctional component of cheese manufacture that contributes to flavor, microbial control, moisture regulation, texture formation, product safety, and shelf stability. However, the association between excessive dietary sodium intake, elevated blood...

Artificial Intelligence as a Catalyst for Novel Therapeutic Opportunities in Precision Oncology

Artificial intelligence (AI) is reshaping molecular oncology by making complex biological data tractable and by extending the reach of precision drug discovery. Its emerging value is particularly evident at the interface of immunoengineering and targeted therapy, where computatio...

Antiviral Sesquiterpene Lactones from Laurus nobilis L.: Inhibition of Hepatitis C Virus and Dengue Virus Replication

Natural products remain indispensable scaffolds in antiviral drug discovery, particularly against high-burden viral pathogens. In this study, two major sesquiterpene lactones, dehydrocostus lactone (1) and costunolide (2), were isolated from Laurus nobilis L. leaves and evaluated...

Vitamin D in coronary heart disease: a Mendelian randomization meta-analysis of data stratified by 25(OH)D levels

Maria Fusaro, Pasquale Perrone Filardi, Gianfranco Sinagra, Maria Luisa Brandi, Maurizio Gallieni, Jean-Yves Reginster, Eugene McCloskey, Etienne Cavalier,

Dermatologic Toxicities Associated with Tebentafusp for Uveal Melanoma: A Review of Clinical Trials and Real-World Evidence

Tebentafusp is a first-in-class bispecific fusion protein that redirects T cells toward gp100-expressing cells and represents the first systemic treatment shown to improve overall survival in patients with HLA-A*02:01-positive metastatic uveal melanoma. As gp100 is also expressed...

Mental health and substance use in Europe: initial steps towards a common European approach

BACKGROUND AND AIMS: Comorbid substance use and other mental health disorders contribute to more than one million years lived with disability in Europe according to the Global Burden of Disease study. They require a comprehensive approach, yet, in Europe, there is considerable va...

Synergism Between Krameria lappacea (Dombey) Burdet & B.B.Simpson Extracts and Gentamicin Against Gram-Positive Bacteria

Background: Combination therapy is increasingly explored as an alternative approach to manage bacterial infections and limit the emergence of antibiotic resistance. Building on traditional medicinal knowledge, this study aimed to investigate the potential synergistic antibacteria...

Phraseology and phraseodidactics. Current status and future prospects

Abstract Phraseodidactics is a transdisciplinary field of research that makes findings from research on phraseology directly applicable to language teaching. Since successful communication is largely based on pre-formed multi-word units (MWUs), also referred to as phrasemes, the...

Interest in geriatric medicine training among health and social care professionals: the roles of experience and attitudes. Findings from the online survey of the COST Action PROGRAMMING 21122

Abstract Background The growth of ageing populations is increasing the requirement for professionals trained to care for older adults. Aims To explore factors associated with interest in further training in geriatrics across health and social care professionals. Methods The COST...

Control of semiconductor surface morphology and wettability via nanosecond laser texturing

Efficient thermal management in modern compact electronics requires surfaces with controlled wettability and strong wicking capability. Although laser-textured silicon is widely studied for its optical response, its wetting and capillary transport properties remain less explored....

Black Pleural Effusion as a Rare Presentation of Serotype 3 Pneumococcal Empyema

Black pleural effusion (BPE) is exceptionally rare in children, with only 1 previously reported pediatric case linked to a pancreaticopleural fistula, while adult cases are typically associated with rupture of pancreatic pseudocysts, malignancy, fungal infection, or hemorrhage. A...

Beyond Blood and Urine: Decoding the Human Chemical Exposome across Matrices and Time

Abstract Environmental chemicals contribute substantially to the global burden of chronic disease, yet for most compounds now detectable in human biological samples, causal links to specific health outcomes remain poorly established. HRMS can profile thousands of chemical feature...