National and Kapodistrian University of Athens

Regulated Cell Death in Reproductive Biology: Mechanisms and Therapeutic Opportunities

Regulated cell death (RCD) has emerged as a fundamental determinant of cellular homeostasis and tissue remodeling, extending far beyond the classical concept of apoptosis. The identification of emerging RCD pathways, including ferroptosis, pyroptosis, necroptosis, cuproptosis, PA...

Validation of the International Working Group 2023 response criteria for higher risk myelodysplastic syndromes/neoplasms using the International Consortium for Myelodysplastic Syndromes VALIDATE database and a randomized phase III trial

Response assessment criteria in patients with higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) have been updated in the 2023 International Working Group (IWG) criteria. However, validation of these criteria has been limited to date. We analyzed overall survival (OS) by be...

The TET Protein Family in Gliomas: Epigenetic Regulation, Molecular Pathogenesis, and Therapeutic Opportunities

Epigenetic dysregulation is a defining feature of glioma pathogenesis, with aberrant DNA methylation contributing to tumor initiation, cellular plasticity, progression, and therapeutic resistance. The ten-eleven translocation (TET) family of dioxygenases (TET1, TET2, and TET3) ca...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

Treatment of male osteoporosis: a narrative review and position statement by the ECTS Clinical Action Group.

Osteoporosis in men is under-recognized and under-treated despite a substantial disease burden and poorer fracture-related outcomes than in women. Secondary osteoporosis is highly prevalent in men, making the identification and management of underlying causes essential. Bone mine...

Sartans and Bisartans: Expanding Therapeutic Horizons Through Broad Receptor Interactions and Repurposing Potential

Angiotensin receptor blockers (ARBs), also known as sartans, are a family of highly selective angiotensin II type 1 receptor antagonists commonly prescribed to individuals with hypertension, heart failure, and chronic kidney disease. Additionally, the discovery and facile synthes...

Can small modular reactors clear the cost screen for Greek noninterconnected islands: A benchmark screening assessment against oil based supply with illustrative renewable storage evidence

Greek noninterconnected islands remain economically distinctive because several still depend on autonomous oil based generation while facing pressure to decarbonize through renewables, storage, and interconnections. This article addresses a limited screening question. Do small mo...

Isometric and Isokinetic Assessment of Shoulder Rotator Muscle Strength, External/Internal Strength Ratios, and Fatigue Response in Competitive Male Gymnasts

This study evaluated shoulder rotator muscle strength, conventional and functional external/internal rotation (ER/IR) strength ratios, and fatigue responses in competitive male artistic gymnasts, compared to a control group consisting of physical education (PE) students. Twenty-s...

The AiPi Knowledge Base: Semantic Framework and Terminology for Interdisciplinary Research Programmes

This paper examines how to address key challenges in developing a custom GPT (AiPi) intended to function as a “philosophical assistant” for knowledge integration in interdisciplinary research programmes. The AiPi (Artificial Intelligence Principal Investigator) is based on an LLM...

Jaw Dimensions, Skeletal Maturation, and Salivary Hormones in Adolescents With Normal and Increased Body Mass Index: A Cross‐Sectional Study

ABSTRACT Objective To evaluate jaw dimensions, skeletal maturation, and salivary hormonal and adipokine levels in adolescents with normal and increased body mass index (BMI). Setting and Sample Population This cross‐sectional study included 50 adolescents (mean age 13.54 ± 1.39 y...

Developmental Language Disorder and Developmental Dyslexia: Rethinking Categorical Boundaries Through a Dimensional Language–Literacy Framework

Developmental Language Disorder (DLD) and developmental dyslexia are among the most prevalent neurodevelopmental disorders affecting children’s language, literacy, academic achievement, and social participation. Although traditionally conceptualised as distinct disorders of oral...

Pastoral AI ethics for chatbots in religious education

Abstract Religious Education faces new ethical challenges as AI-powered chatbots become capable of offering scriptural explanations, moral guidance, and personalized learning support. This theoretical article proposes a Pastoral AI Ethics framework for the responsible use of AI c...

Letters from the Past: Sequenced Multimodal Learning for Historical Empathy in Museums

Museums increasingly employ digital playful experiences to engage younger audiences, yet designing for both engagement and deeper historical understanding remains challenging. This paper presents Letters from the Past, a sequenced multimodal museum learning experience designed to...

Integrated Molecular, Clinicopathological and Immune Profiling of Non-Small Cell Lung Cancer: The MONREPOS Hellenic Cooperative Oncology Group (HeCOG) Study (HE_2TR/13)

Integrated assessment of tumour genomics and immune biomarkers may improve prognostic stratification in non-small cell lung cancer (NSCLC). We examined the distribution and prognostic relevance of somatic pathogenic/likely pathogenic variants (PVs), somatic copy-number alteration...

Lipoprotein and apolipoprotein levels in age-related macular degeneration: A meta-analysis

Purpose Drusen, the hallmark of AMD, are lipoprotein-rich particles. However, the role of systemic lipid metabolism in their formation remains controversial. This meta-analysis explored the association between ApoA1, ApoA2, ApoB and Lp(a) serum levels and AMD. Methods We systemat...

Diagnostic Performance of the Lymphocyte Transformation Test and Patch Testing in Delayed Hypersensitivity Drug Reactions

Background: Cutaneous adverse drug reactions (CADRs) occur in 2–5% of inpatients, primarily due to delayed (T-cell-mediated) reactions, such as maculopapular exanthemas (MPEs). The lymphocyte transformation test (LTT) detects drug-specific T-cell responses with varied sensitivity...

Psychological resilience as a key pathway between depression and executive functioning in epilepsy

Introduction In epilepsy, the burden of depression extends beyond mood, often accompanying difficulties in executive functioning. However, the psychological factors shaping this relationship remain largely unexplored. This study examines whether psychological resilience serves as...

Technological dynamism and labor investment efficiency: exploring strategic resilience

This study contributes to the literature by exploring the impact of technological dynamism (TD) on labor investment efficiency, analyzing non-financial U.S. firms listed on the S&P 500 index from 1993 to 2023. Employing a novel TD measure based on industry-level R&D intensity, we...

Infectious triggers in IgA vasculitis in children: current evidence, causal attribution and immunopathogenic mechanisms

Abstract IgA vasculitis (IgAV) is the most common systemic vasculitis in childhood. Its seasonal distribution and frequent respiratory or gastrointestinal prodromes implicate environmental exposures. However, microbiological detection temporally proximate to disease onset is insu...