National and Kapodistrian University of Athens

Machine learning integrated explainable artificial intelligence in predicting toxicities of enfortumab vedotin in urothelial carcinoma: an exploratory study

Background Enfortumab vedotin (EV) therapy for advanced urothelial carcinoma is limited by adverse events (AEs). Early identification of high-risk patients is needed. This proof-of-concept study evaluated whether machine learning (ML) with explainable AI (SHAP) could predict EV t...

Resilience of ant communities (Hymenoptera: formicidae) to moderate urban disturbance in a mediterranean peri-urban landscape

Abstract Human activities alter the biotic and abiotic characteristics of the environment, affecting species richness, population abundances and community composition. Nevertheless, these activities intensify as we move from forested areas to the center of urban cities, with peri...

Development and Preliminary Evaluation of a Questionnaire on Parental Informed Consent in Neonatal Research

Background: Advances in neonatology and paediatric pharmacology have markedly improved neonatal survival, particularly among preterm and critically ill infants. At the same time, clinical research constitutes the cornerstone for generation of evidence on the safety and efficacy o...

Foreign language learners responding to thanks

Abstract This study sets out to investigate the extent to which proficiency enhances foreign language (FL) learners’ pragmatic competence in responding to thanks. Drawing on data from Greek FL learners of two proficiency levels (lower-intermediate and advanced) and supplemented b...

Fear of death increases nocebo-prone behavior in people with headaches during covid-19. A longitudinal observational survey

BACKGROUND: The nocebo effect greatly affects pain management. We investigated the nocebo-prone behavior in people with headaches during and after the COVID-19 pandemic, for which there is clear evidence that the nocebo effect increased. METHODS: Individuals with headaches comple...

Colour Doppler ultrasound assessment of retrobulbar hemodynamics and static retinal vessel analysis in Sjögren’s disease: the SICARD cohort

Abstract Objectives To assess, for the first time, macrovascular, medium-calibre vessel, and microvascular damage in Sjögren’s disease (SjD) using carotid greyscale ultrasound (GSUS), retrobulbar colour Doppler ophthalmic artery (OA) ultrasound (RCDUS), and static retinal vessel...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Metabolic Dysfunction-Associated Steatotic Liver Disease in Childhood: From Disease Heterogeneity to Personalized Care

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has become the most common chronic liver disease in childhood, paralleling the global increase in pediatric obesity and metabolic dysfunction. Once considered a benign condition, pediatric MASLD is now recognized as...

Non‐contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor‐Associated Intracerebral Hemorrhage: An Analysis from ANNEXa ‐I Trial

In this post hoc analysis of the ANNEXa-I trial (n = 434), we evaluated non-contrast computed tomography (NCCT) markers of hematoma expansion (HE) in factor Xa inhibitor (FXai) -associated intracerebral hemorrhage (ICH). At least one NCCT marker was present in 72.1%, and HE (≥12....

BMAL1 Dysregulation as a Contributing Mechanism Linking Obesity to Oocyte and Endometrial Dysfunction in IVF

Obesity affects nearly one in three women of reproductive age worldwide and consistently reduces success rates in in vitro fertilization, yet the molecular basis for this reduction remains fragmented across separate lines of evidence. Circadian clock genes, particularly BMAL1, or...

The Fibro-Inflammatory Ovary: Stromal Fibrosis, Extracellular Matrix Remodeling, and Mechanotransduction in Female Infertility

Endocrine disorders and inherent flaws in oocyte quality are traditional causes of female infertility. Increasing research indicates that structural and biomechanical alterations in the ovarian microenvironment may significantly contribute to reproductive decline. Progressive ext...

Dust radiative effects and impact on energy production over the Mediterranean Basin

Abstract. Atmospheric aerosols are among the key factors affecting the Earth’s radiation budget, playing a fundamental role in understanding climate forcing, feedback mechanisms, and their impact on future climate projections and on solar energy systems. More specifically, dust a...

Dynamics of Santorini Volcano During Earthquake Swarm 2025 Based on Gravity Monitoring Supported by GNSS

Abstract This study investigates gravity changes in the Santorini volcanic island (South Aegean Sea, Greece) before, during and after the ‘February 2025’ seismic crisis, with the aim of detecting subsurface mass changes. Four gravity campaigns were conducted between September 202...

The Greek Version of the Child Oral Health Impact Profile‐Short Form 19: Translation, Cultural Adaptation and Psychometric Properties

ABSTRACT Objectives Tools evaluating how oral health affects the quality of life in children serve as valuable patient‐related outcome measures (PROMs). This study aimed to develop a culturally adapted Greek version of the Child Oral Health Impact Profile‐Short Form 19 (COHIP‐SF...

Different learners, different journeys: affective and cognitive diversity in response to an ELF-aware speaking intervention

Abstract This qualitative study explores learner responses to an English as a Lingua Franca (ELF)-aware speaking intervention in a lower secondary school in Greece, where learning English is dominated by certification goals and classroom disengagement in state schools is common....

The Volatile Profile and Seasonal Shifts of Greek-Grown Yuzu (Citrus junos) Peels and Leaves

This study presents the first characterization of peel and leaf essential oils (EOs) from Citrus junos Sieb. ex Tanaka (yuzu) cultivated in Greece, evaluating seasonal maturation effects on their chemical profiles. EOs were extracted through hydrodistillation from samples harvest...

Vitamin D Levels and Skeletal Quality of Life in Adult Langerhans Cell Histiocytosis

Abstract Objective To prospectively evaluate the association between vitamin D optimization and quality of life (QoL) and bone metabolism in adult patients with Langerhans cell histiocytosis (LCH). Design and Methods: In this prospective, uncontrolled, observational study, 45 adu...

Anatomical variants of circumaortic left renal vein

The circumaortic left renal vein (CLRV) is a critical retroperitoneal vascular variant.Current classification systems frequently omit possible morphologies.This study aims to delineate intricate CLRV patterns and propose a preliminary classification framework.Contrast-enhanced ab...

IGF-1Eb Isoform Immunoreactivity May Be Associated with Placental Dysfunction and Vascular Pathology in Fetal Growth Restriction (FGR)

Background: Fetal growth restriction (FGR) is associated with placental dysfunction and adverse perinatal outcomes. Although insulin-like growth factor-1 (IGF-1) signaling is important for placental and fetal development, the mRNA expression, immunopositivity and potential biolog...

Cause of death in a contemporary cohort of patients with pulmonary arterial hypertension

Abstract Background In pulmonary arterial hypertension (PAH), contemporary risk tools primarily estimate all-cause mortality, offering limited insight into what patients die from. Aims We aimed to characterize causes of death across baseline risk strata and to examine baseline fa...