Nankai University

Structural Characterization and Immunomodulatory Activity of Acid-Extracted Polysaccharides from Chestnut ( Castanea Mollissima Blume)

Abstract Chestnut (Castanea mollissima Blume) is a nutrient-rich nut; however, the immunomodulatory potential of its polysaccharides remains underexplored. In this study, three extraction methods (hot water, acid, and alkaline) for chestnut polysaccharides were compared in terms...

Non-Canonical Peptide Self-Assembly for Mitochondria-Specific Cargo Delivery

Abstract Targeting mitochondria is a promising strategy for precision tumor therapy, yet ligand-free mitochondrial drug delivery remains challenging. Here, we report a minimalist, intrinsically mitochondria-targeting noncanonical tetrapeptide, X-GNNpY, comprising one glycine, two...

Optimal Model Selection for Conformalized Robust Optimization

In decision-making under uncertainty, Contextual Robust Optimization (CRO) provides reliability by minimizing the worst-case decision loss over a prediction set. While recent advances use conformal prediction to construct prediction sets for machine learning models, the downstrea...

Fragmentomic features of cell-free DNA in human spent blastocyst medium and their potential for non-invasive embryo ploidy assessment

To characterize the fragmentomic features of cell-free DNA (cfDNA) in spent blastocyst medium (SBM) and their association with embryonic chromosomal status. One hundred fifty SBM samples were obtained from 43 preimplantation genetic testing for aneuploidy (PGT-A) cycles in 39 pat...

Nanoparticle‐Based Delivery Strategies for Targeted Protein Degradation

Targeted protein degradation (TPD) has fundamentally redefined pharmacological intervention, shifting from classical occupancy-driven inhibition to event-driven elimination of undruggable pathogenic proteins, holding great promise for treating various intractable diseases. Althou...

Stabilization and Regulatory Strategies for All‐Inorganic Cesium Lead Halide Perovskite Black Phase

ABSTRACT All‐inorganic CsPb X 3 perovskites (PVK) are regarded as a key solution to the intrinsic instability of organic–inorganic hybrids due to their excellent thermal stability. However, the photoactive black phase is thermodynamically metastable at room temperature because of...

Reheating-Induced Matrix Reorganisation Modulates the In Vitro Digestibility of a Retrograded Normal/High-Amylose Maize Starch Blend

Reheating alters residual molecular order and matrix architecture in retrograded starch, but these changes do not necessarily produce parallel changes in enzymic digestion. Gels of normal maize starch (NM), high-amylose maize starch (HM), and a 50/50 (w/w) NM/HM blend were stored...

ProactiveAudioBench: Evaluating Condition-Driven Responses in Audio Streams

Audio assistants are moving from turn-based question answering toward continuous listening, where they must interpret incoming audio while deciding whether to respond or remain silent. Existing proactive benchmarks emphasize video and audiovisual interaction, while audio-centric...

Triglyceride–glucose body roundness index and risks of incident cardiovascular disease and cardiometabolic multimorbidity: evidence from prospective cohorts in China and England

Cardiovascular disease (CVD) and cardiometabolic multimorbidity (CMM) impose substantial health burdens. The triglyceride–glucose body roundness index (TyG-BRI) integrates metabolic dysfunction reflected by TyG with body-shape information reflected by BRI, but its associations wi...

LAMAR-Bench: Evaluating Long-Form and Multi-Audio Understanding and Reasoning

Audio-language models increasingly process long recordings and multiple audio inputs, requiring fine-grained acoustic understanding, cross-audio reasoning, and decisions under goals and constraints. Existing benchmarks cover these requirements unevenly, while answer accuracy can...

Spatial optimization of land use for synergizing economic development and carbon neutrality based on an efficiency-driven PLUS model

Optimizing land-use allocation is important for achieving regional carbon-peaking and carbon-neutrality targets. Existing land-use simulation studies generally incorporate carbon objectives through ex-post assessment or macro-level land-demand optimization, leaving historical gri...

Design, Synthesis, and Antimicrobial Activity of Novel Cyt- bd Inhibitors Targeting Energy Compensation in Mycobacterium tuberculosis

Abstract Drug-resistant Mycobacterium tuberculosis (Mtb) poses a growing threat, necessitating new therapeutic strategies. The cytochrome bcc-aa3 oxidase (Cyt-bcc) is an attractive target, yet single-agent inhibition fails owing to compensation by the alternative cytochrome bd te...

Kirigami-actuated reconfigurable topological photonic crystals

Photonic crystals are typically fabricated with a fixed topology, freezing their edge and corner states in space and frequency. Here we introduce a kirigami-actuated reconfigurable topological photonic crystal in which a single in-plane rotation reshapes the unit cell, drives a b...

Biocatalytic Synthesis of dNTPs from Bacterial Biomass

Abstract Deoxyribonucleoside triphosphates (dNTPs) are crucial reagents widely utilized in nucleic acid amplification. However, current synthesis methods are often plagued by environmental pollution for chemical synthesis and the high costs of phosphate donors for enzymatic synth...

Heteronuclear Dual‐Atom Catalysis Boosts Reversible Li 2 S Deposition–Decomposition for Wide‐Temperature Lithium–Sulfur Batteries

ABSTRACT Wide‐temperature operation is essential for practical application of Li─S batteries. Constructing efficient electrocatalysts is an effective strategy to simultaneously alleviate sluggish conversion kinetics at low temperatures and aggravated lithium polysulfide shuttling...

Regulating Singlet Oxygen Generation via a Z-Scheme IEF-11/TiO2 Heterojunction for Degradation of Phenolic Pollutants

Abstract Photocatalytic technology has emerged as a promising strategy for the treatment of phenolic contaminants in wastewater. Upon light irradiation, it produces highly reactive oxidative species, which can promote the significant mineralization of pollutants. Herein, Ti-MOF (...

Transforming Cadmium in Paddy Soils into a Catalytic Driver for Chlorantraniliprole Degradation: Implications for an Integrated Strategy for Tackling Heavy Metal–Organic Cocontamination

Abstract Developing remediation strategies for heavy metal–organic cocontamination in paddy soils is imperative to ensure food safety. Current soil remediation strategies typically address these pollutant classes separately, often creating trade-offs in which mitigating one class...

Energy storage for a flexible and decarbonized power system in China: Pathways and regional deployment

The power system transition is central to achieving China's dual‑carbon targets of carbon peaking by 2030 and carbon neutrality by 2060. The rapid expansion of variable renewable energy (VRE) has made pumped hydro storage (PHS) and battery energy storage systems (BESS) critical f...

Dupilumab Alleviates Pulmonary Fibrosis by Interrupting Profibrotic Macrophage-Fibroblast Crosstalk and IL4R/JAK/STAT Signaling

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD) of unclear etiology. Dupilumab, a humanized monoclonal antibody binding to interleukin-4 receptor alpha (IL-4Rα), suppresses both IL-4 and IL-13 signaling pathways. However, the therapeu...

FedBCFA: a boundary-constrained feature alignment federated learning framework for multi-center breast MRI classification

Multi-center medical image modeling faces persistent challenges arising from data privacy constraints and cross-institutional distribution discrepancies. Federated learning provides a feasible paradigm for collaborative training of intelligent diagnostic models for breast magneti...