Nankai University

Strong and crack-tolerant elastomers via geometrically confined H-bonding semicarbazides

The development of high-performance elastomers that are simultaneously strong, crack-tolerant, and wear-resistant remains a persistent challenge. Herein, we design bio-inspired semicarbazide chain extender featuring high-density hydrogen-bonding sites to synthesize poly(urethane-...

Woven dECM yarn scaffolds enable volumetric muscle loss regeneration via immunomodulation

Volumetric muscle loss (VML) represents a significant unmet clinical need in current medical practice. Decellularized extracellular matrix (dECM) offers a promising clinical approach. However, its inherent architecture impedes adaptive topological guidance for rapid cellular infi...

Structural lipidomics identifies murine plasma C=C location isomers for radiation dose stratification

Abstract Background Rapid and early radiation biodosimetry is essential for post-exposure medical triage and timely intervention. Owing to their high radiosensitivity, lipids are promising biodosimetry biomarkers. However, radiation-induced structural alterations, particularly ch...

Venetoclax for elderly patients with acute myeloid leukaemia unfit for intensive chemotherapy: Prospects, resistance mechanisms and management strategies

To date, the treatment of acute myeloid leukaemia (AML) remains a major challenge in hematologic malignancies, particularly among elderly patients who are unfit for intensive chemotherapy. Venetoclax, a BCL-2 inhibitor, in combination with azacitidine, has significantly improved...

Hypoxia combined with vitamin C and N-acetylcysteine attenuates telomere shortening and replicative senescence in human umbilical cord mesenchymal stem cells

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) are promising candidates for regenerative medicine; however, prolonged in vitro expansion promotes oxidative stress, replicative senescence, functional deterioration, and telomere attrition. This study evaluated wheth...

Machine Learning–Based Cytokine Endotyping of Thyroid Eye Disease

Purpose: Thyroid eye disease (TED) exhibits profound phenotypic heterogeneity that conventional binary thyrotropin receptor antibody fails to capture. We aimed to deconstruct this heterogeneity by establishing a cytokine-derived molecular taxonomy. Methods: We profiled 102 plasma...

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

ABSTRACT Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Patients with IBD receive therapy to correct these imbalances and achieve remission. However, most patients...

Four Spices Differentially Modulate Roasted Beef Patty Quality and Fluorescent ALEs Formation via Carbonyl Precursors

The accumulation of dietary advanced lipid oxidation end-products (ALEs) in thermally processed meat products is closely associated with quality deterioration and potential health risks. Spices are widely recognized for both flavoring and antioxidant properties and may therefore...

A product formula for family indices and family band width estimates

We extend Gromov’s conjecture on the sharp width estimate for Riemannian bands with positive scalar curvature to the family case and prove that it holds for fiber bundles with infinite family \hat{A} -area. The method we employ is based on Dirac operators and the family index the...

Ionizing Radiation Induced Strain Engineering for Exciton Dynamics in Atomically Thin Semiconductor

ABSTRACT Uncovering and controlling exciton dynamics in atomically thin semiconductors is crucial for excitonic devices. While conventional techiniques often damage materials, ionizing radiation offers a non‐contact, low‐cost modulation method. Here, we introduce a non‐destructiv...

Association between PD-1/PD-L1 Expression and Clinicopathological Parameters as well as Prognosis in Neuroendocrine Neoplasms of the Digestive System: A Systematic Review and Meta-Analysis

Abstract Neuroendocrine neoplasms (NENs) are a highly heterogeneous group of tumors originating from the neuroendocrine system, predominantly occurring in the gastrointestinal tract and lungs. This meta-analysis aimed to clarify the association of programmed death 1 (PD-1)/progra...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

A layered dynamic material flow framework for modeling building renovations

Abstract Dynamic material flow analysis (dMFA) is widely used to study the material demands of residential building stocks. In most of the studies conducted to date, buildings are modeled as homogeneous units instead of a system of components. A limitation of this assumption is t...

Evaluating the Stability of Oxide‐Derived Cu─Sn Catalysts for CO 2 Reduction in Zero‐Gap Electrolyzers

ABSTRACT Bimetallic electrocatalysts hold substantial potential for scaling up CO 2 electroreduction, yet their practical deployment is hindered by a persistent gap between conventional three‐electrode testing and industrially relevant electrolyzer conditions. In this study, we e...

XPO1-mediated TRIM21 nuclear export reprograms TREM2+ macrophage polarization by targeting IRF3 to augment anti-PD-1 efficacy in small cell lung cancer

Abstract Small cell lung cancer (SCLC) is an aggressive malignancy that responds poorly to immune checkpoint inhibitor (ICI) therapy, due to its immunosuppressive tumor microenvironment. Here, we analyse preclinical mouse tumor models and patient-derived SCLC samples and identify...

From chemical oscillators to biological synchrony: a programmable reaction-diffusion model for studying signal coordination in cardiomyocyte networks

Abstract The self-organization of asynchronous rhythms into synchronized beating in in vitro cardiomyocyte networks is a fundamental problem in systems biology research. Inspired by the dynamics of chemical oscillators, this paper presents a programmable model framework based on...

Ultrasound-Activated Janus Heterojunction-Mediated Enhanced Cascade Nanozyme for Inflammatory Bowel Disease Therapy

Abstract Inflammatory bowel disease (IBD) is exacerbated by the excessive accumulation of reactive oxygen species (ROS). To overcome the insufficient catalytic activity of conventional cerium-based nanozymes, we designed an ultrasound-activated Bi@BTC heterojunction nanozyme. The...

Reconstructing pharyngealized vowels for Qieyun Division II in Middle Chinese

Abstract It is widely accepted that Middle Chinese Division II, a syllable category in Middle Chinese, originates from the Old Chinese medial *-r-, yet its reconstruction remains debated. Existing proposals assign Division II a palatal, velar, or r-colored feature or segment. Bui...

Mandated to Change, Pressured to Survive: How Newly Appointed CEOs Use Resonance to Manage Strategic Change–Early Survival Dilemma

Abstract Newly appointed CEOs often enter office with a mandate to initiate strategic change, yet such change disrupts established routines and interests, frequently provoking resistance from organizational stakeholders. This creates a fundamental leadership transition dilemma: t...

Dynamically Tunable Exciton‐Photon Coupling via Multi‐Physics Field in Transition Metal Dichalcogenide Microcavities

ABSTRACT Atomically thin transition‐metal dichalcogenides (TMDs) host tightly bound excitons with large oscillator strengths, making them ideal for studying light‐matter interactions and polaritonic devices. When integrated with optical microcavities, TMD monolayers and van der W...