Nankai University

Dupilumab Alleviates Pulmonary Fibrosis by Interrupting Profibrotic Macrophage-Fibroblast Crosstalk and IL4R/JAK/STAT Signaling

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD) of unclear etiology. Dupilumab, a humanized monoclonal antibody binding to interleukin-4 receptor alpha (IL-4Rα), suppresses both IL-4 and IL-13 signaling pathways. However, the therapeu...

Accelerated Charge Recombination in MOF Cocrystals Enables Efficient NIR‐Driven Photothermal Polymerization

Understanding charge transfer across donor-acceptor interfaces is essential for designing high-performance optoelectronic materials. Herein, we construct host-guest metal-organic framework (MOF) cocrystals employing a calcium-based naphthalenediimide (NDI) host and electron-rich...

Synthesis of a Stable Crystalline Dibenzopentacene Triplet Diradical via a Protection–Oxidation–Protection Strategy

ABSTRACT The synthesis of triplet‐ground‐state 1,14:11,12‐dibenzopentacene (DP) has been sought after for over 60 years, but the isolation of stable derivatives in crystalline form has been unsuccessful. Herein, we report the synthesis and first single‐crystal isolation of a stab...

Postoperative pain and 12-month periapical healing after Er: YAG laser–activated versus ultrasonic irrigation: a randomized controlled trial

Abstract Background This randomized controlled clinical trial evaluated contemporary irrigation activation strategies by integrating patient-reported postoperative pain with 12-month radiographic healing outcomes. Er: YAG laser–activated irrigation using photon-induced photoacous...

Outward Charge-Enriched Boundaries Stabilize Halide–Sulfide Solid–Electrolyte Interfaces

Abstract Halide–sulfide bilayer electrolytes offer a practical route toward all-solid-state lithium batteries by combining the high-voltage compatibility of halide electrolytes with the favorable interfacial contact and Li+-transport characteristics of sulfide interlayers. Howeve...

Synthesis of a Stable Crystalline Dibenzopentacene Triplet Diradical via a Protection–Oxidation–Protection Strategy

ABSTRACT The synthesis of triplet‐ground‐state 1,14:11,12‐dibenzopentacene (DP) has been sought after for over 60 years, but the isolation of stable derivatives in crystalline form has been unsuccessful. Herein, we report the synthesis and first single‐crystal isolation of a stab...

Accelerated Charge Recombination in MOF Cocrystals Enables Efficient NIR‐Driven Photothermal Polymerization

ABSTRACT Understanding charge transfer across donor‐acceptor interfaces is essential for designing high‐performance optoelectronic materials. Herein, we construct host‐guest metal‐organic framework (MOF) cocrystals employing a calcium‐based naphthalenediimide (NDI) host and elect...

Polyamine metabolism related prognostic genes and risk model in prostate cancer insights into tumor microenvironment and drug sensitivity

Abstract Background Polyamine metabolism (PM) is linked to the progression and prognosis of several cancers, but the specific mechanism of Polyamine metabolism-related genes (PMRGs) in Prostate carcinoma (PCa) is not fully understood. This study aims to construct and validate a P...

Guidelines for workplace vigilantes: the influence of punishment altruism and gender on bystander behavior

Purpose Workplace vigilantes are individuals who monitor and punish deviants without formal authority. This study aims to examine how punishment altruism and workplace vigilante gender influence bystander behavior. Design/methodology/approach Drawing on the cognitive appraisal th...

Disentangling the effect of space and electric field on photoelectrochemical water splitting

Photoelectrochemical water splitting is a promising pathway for renewable solar fuel production. The photoelectrochemical performance strongly depends on the charge separation ability within the space charge layer. In space charge layer, the charge dynamics should be governed by...

Interaction effects and load-oriented scheduling of multiple actuators in a gas engine-driven VRF system under heating condition

This study investigates the interactions among the liquid injection cooling expansion valve (LICV), hot gas bypass expansion valve (HGBV), and engine speed in a gas-engine-driven variable refrigerant flow system, with the aim of improving heating performance and primary energy ef...

The Python simulations of chemistry framework: 10 years of an open-source quantum chemistry project

Over the past decade, the Python-based Simulations of Chemistry Framework (PySCF) has developed into a widely used open-source platform for electronic-structure theory and quantum chemical method development. This article reviews the major advances since the previous overview in...

Estimation of an average causal response function in a high-dimensional sample selection model with application to US Job Corps program

Average causal response function (ACRF) is a valuable tool for assessing treatment effects with dose functions, particularly in the presence of endogeneity. Motivated by the US Job Corps program, this paper studies the identification and estimation of an ACRF under sample selecti...

Pore Space Partition in Indolo[3,2- b ]carbazole-based Zr-MOF via Post-Synthetic Linker Installation for Enhanced Ethane/Ethylene Separation

Abstract The separation of ethane (C2H6)/ethylene (C2H4) by metal–organic frameworks (MOFs) depends largely on the pore environment. Here we construct a C2H6-selective mesoporous Zr-MOF, NUT-77, using indolo[3,2-b]carbazole-based tetracarboxylate ligands, and then apply post-synt...

Phys-AbGAT: A Physics-Informed Multi-Task Graph Attention Network for Robust Antibody-Antigen Binding Affinity Prediction

Abstract Motivation Accurate prediction of antibody-antigen binding affinity is essential for therapeutic antibody design. Existing methods often model the dissociation constant (KD) and Gibbs free energy (ΔG) independently, overlooking their thermodynamic relationship and comple...

Global Reanalysis Reveals Recurrent Cyanobacterial Enrichment in the Aquatic Plastisphere

Abstract The plastisphere is an emerging anthropogenic ecosystem hosting complex microbial assemblages. While heterotrophic colonizers are well studied, the role of primary producers such as cyanobacteria remains underexplored. Here, we reanalyzed 16S rRNA gene amplicon data from...

Stereoselective polysubstituted bicyclo[1.1.0]butane synthesis by rhodium-catalyzed kinetic resolution

Bicyclo[1.1.0]butanes (BCBs) are a distinctive class of strained small-ring carbocycles of growing importance in synthetic and medicinal chemistry. However, the enantioselective synthesis of polysubstituted BCBs remains a largely unsolved challenge. Herein, we report a general ch...

Promoting green governance: government procurement and corporate green governance performance

Promoting corporate green governance is essential for sustainable development. Using a panel of Chinese A-share listed firms from 2015 to 2023, this paper examines how government procurement influences corporate green governance performance. The results reveal that receiving gove...

PMF Coupled With Random Forest Method Reveals Detailed PM 2.5 Sources and Their Synergistic Effects on Air Pollution Control

Abstract Understanding the sources of emerging PM 2.5 pollution is crucial for developing effective air quality management strategies. This study combines positive matrix factorization (PMF) with random forest (RF) classification to reveal a detailed PM 2.5 source identification...

Construction Suitability and Influencing Factors in Abandoned Mining Areas Based on Machine Learning: A Case Study of Luhe District, Nanjing, China

Land disturbance and ecological degradation are widespread in abandoned mining areas, and their redevelopment is shaped by multiple factors. Identifying construction suitability patterns and key influencing factors can provide a quantitative basis for the reuse of these areas. Fo...