Nanjing University of Chinese Medicine

Cynarin Targets Host CX3CR1 for Dual-Action Prophylaxis against RSV Infection and Pulmonary Pathology

Abstract Safe, small-molecule prophylactic agents against respiratory syncytial virus (RSV) are critically lacking. Here, we identify Cynarin, an artichoke-derived dietary polyphenol, as a micromolar affinity CX3CR1 antagonist. Mechanistically, Cynarin confers dual-action protect...

Multiregional single cell profiling reveals LGALS9 and CD44 mediated niche remodeling crosstalk in metastatic breast cancer

Abstract The transition from intraductal to invasive Breast cancer (BC) is driven by complex interactions within the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs), a key stromal component, critically influence extracellular matrix remodeling, immune modulatio...

Allostatic load, genetic susceptibility, and lung cancer risk: Evidence from a prospective cohort and integrative proteomic analyses

Allostatic load (AL), a composite measure of multisystem dysregulation associated with chronic stress, has been linked to lung cancer risk. However, its joint effects with genetic susceptibility and the biological pathways underlying this relationship remain unclear. We conducted...

The Longitudinal Association Between Disability and Loneliness Among Older Adults in China: An Urban–Rural Comparative Analysis

Loneliness is a major mental health concern among older adults and has been increasingly linked to functional decline in later life. This study aimed to inform targeted care strategies by exploring urban–rural differences in the longitudinal association between disability and lon...

A machine learning model for in-hospital mortality prediction in patients with sepsis-related myocardial injury

Sepsis-related myocardial injury (SRMI) is associated with high mortality, but the transportability of prediction models across heterogeneous cohorts remains uncertain. We developed and externally validated a machine learning model for in-hospital mortality prediction in SRMI and...

Route-Dependent Effects of Pre-Existing Anti-Ad5 Immunity on Systemic, Mucosal and Lymph Node B Cell Responses to an Ad5-Vectored Vaccine

Background/Objectives: Pre-existing anti-Ad5 immunity (PEI) impairs the immunogenicity of intramuscular (IM) Ad5-vectored vaccines. Whether respiratory immunization can better preserve vaccine-induced immunity remains unclear. Methods: We established a murine PEI model to compare...

Reliability and quality of colorectal cancer-related health information videos on social media platforms: a cross-sectional study

Social media video platforms have become major sources of colorectal cancer (CRC) information, yet the reliability and educational value of CRC-related videos remain uncertain across platforms. This study aimed to compare the reliability, overall quality, and educational usabilit...

Micro/Nanostructured Materials and Microfluidic Diagnostic Platforms Enable Multimodal Detection of Circulating Tumor Cells

ABSTRACT Circulating tumor cells (CTCs), as pivotal targets in liquid biopsy, offer dynamic, multidimensional insights into tumor heterogeneity and metastatic progression. However, their extreme rarity, pronounced heterogeneity, and the complexity of the blood microenvironment se...

Sequential Hydrogen Atom Transfer‐Mediated Electrochemical Diselenylation of Oxindoles to Access Antifungal gem ‐Diselenides

Herein, we report a sustainable and efficient electrochemical strategy for the direct C(sp 3 )─H gem ‐diselenylation of oxindoles. This protocol proceeds under oxidant‐ and metal‐free conditions, exploiting the synergistic interplay between electrochemical activation and iodide m...

Spatial Au + Mapping Reveals a Self‐Amplifying Anti‐Tumor Immunity Loop Driven by Au(I) Complexes

ABSTRACT Although many metal complexes exhibit promising chemoimmunotherapeutic effects by inducing immunogenic cell death (ICD), the precise regulation of how these complexes interact with immune cells remains unclear. Herein, we introduced Au9 as the first representative gold c...

Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset

ABSTRACT Chronic stress potentially accelerates aging and increases age‐related disease risk. However, the underlying mechanisms and organ specificity remain unclear. Utilizing a 12‐month unpredictable chronic mild stress (UCMS) mouse model, we revealed chronic stress significant...

Clinical Outcomes of Peripheral Magnetic Stimulation in Patients with Functional Defecation Disorders

Aim: This article aims to evaluate the therapeutic efficacy of peripheral magnetic stimulation (PMS) and its effects on anorectal sensorimotor function in patients with functional defecation disorders. Methods: This uncontrolled retrospective study reviewed the clinical data of p...

Association between circadian syndrome and biological age acceleration among Chinese middle-aged and older adults: evidence from CHARLS

Circadian syndrome (CircS), characterized by circadian rhythm disruption and metabolic abnormalities, has been associated with various adverse health outcomes. However, its association with biological age acceleration remains unclear. This study aimed to investigate the associati...

Oral Nano-Oxygen Modulates the Intestinal HIF-2α/NEU3/Ceramide Axis to Mitigate NAFLD

Abstract The intestinal hypoxia-inducible factor-2α (HIF-2α)/neuraminidase 3 (NEU3)/ceramide axis has emerged as an important regulator of gut–liver communication in nonalcoholic fatty liver disease (NAFLD). However, systemic inhibition of HIF-2α may interfere with hepatic glucos...

Calcium-Associated Cellular Integrity and MAPK/cAMP Signaling Are Associated with Low-Temperature Acclimation in Schizophyllum commune 20R-7-F01

Temperature is a critical environmental factor affecting fungal growth, morphogenesis, and reproduction. Schizophyllum commune, a model basidiomycete fungus, exhibits remarkable developmental plasticity under environmental fluctuations; however, the mechanisms underlying its adap...

Wildfires diminish vegetation control on surface runoff

Wildfires are increasingly reshaping global terrestrial ecosystems, yet their impacts on the fundamental coupling between vegetation and the hydrological cycle remain poorly understood. Here, we present a global-scale assessment of how wildfire disturbances alter the sensitivity...

Age-Associated Differences in Facial Skin Structure in Chinese Women: a Cross-Sectional Study

Facial skin aging is a process leading to structural degradation and visible phenotypical changes. Prior studies examined age-related skin parameters and suggested accelerated changes occurring in the early 30s, yet precise timing remains insufficiently defined, and few assessed...

A giant Jurassic hunter: the earliest dipluran and its implications for hexapod body pattern evolution

Abstract Hexapoda comprises the hyperdiverse insects and three cryptic, early-diverging lineages, Protura, Collembola, and Diplura, that are key to understanding the hexapod body pattern but remain extremely rare as fossils. Here, we report the earliest dipluran, Sinojapyx gigant...

Neonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice

Early-life nutrition shapes lifelong health, yet the long-term consequences of childhood overnutrition, particularly on musculoskeletal aging, remain unclear. Here, we show that neonatal overfeeding acts as a developmental insult that accelerates age-related sarcopenia in both se...

Predictors of clinical pregnancy after IVF in women with ovarian endometriomas: a propensity score-matched retrospective cohort study

Abstract Background Ovarian endometrioma (OMA) is associated with reduced in vitro fertilization (IVF) success rates. Therefore, the purpose of the study is to investigate risk factors associated with pregnancy outcomes following IVF in women with OMA and assess the predictive ut...