Nanjing University of Chinese Medicine

Modification of Perilla (Perilla frutescens (L.) Britt.) Seed Protein via Physical Treatments for Enhanced Gelation Properties

Perilla (Perilla frutescens (L.) Britt.) seed protein, an underutilized resource derived from medicinal and edible plants, was subjected to ultrasound (400 W, 20 min), pH-shifting (pH 12.0, 1 h), and high-pressure homogenization (90 MPa, 3 cycles), applied individually or in comb...

Quality and reliability of leukaemia-related short video content on Bilibili and TikTok: a cross-sectional study

Abstract Background Short‑video platforms have become a primary source of health information in China, yet the quality and reliability of disease‑related content remain largely unregulated. Numerous cross‑sectional studies have revealed suboptimal quality, significant platform di...

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

ABSTRACT Toosendanin (TSN) is a highly potent natural anticancer compound derived from the fruit of Fructus Meliae Toosendan. In this study, TSN inhibited melanoma cell proliferation and cell‐cycle progression, induced apoptosis, and suppressed metastasis in both in vitro and in...

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

ABSTRACT Developing effective therapies for triple‐negative breast cancer (TNBC) requires the identification of key molecular regulators. Here, among the major m6A modulators, we find that only the reader YTHDC1 is specifically overexpressed in TNBC and correlates to unfavorable...

Integrating multi-algorithm data-driven empirical modeling to unravel structure–antioxidant relationships of medicinal plant polysaccharides

Oxidative stress contributes to the pathogenesis of numerous diseases, and medicinal plant polysaccharides (MPPs) are promising natural antioxidants. However, the substantial structural heterogeneity of MPPs complicates the establishment of reliable structure–activity relationshi...

The Impact of Working Beyond Retirement on Cognitive Function Among the Retirement-Transition Population

With accelerating population aging and retirement-policy reforms, post-retirement work participation and its health effects have attracted increasing attention. Using data from the 2013–2020 waves of the China Health and Retirement Longitudinal Study (CHARLS), this study examined...

Batatasin III alleviates inflammatory bowel disease by suppressing MMP7 and NFκB signaling in macrophages and restoring gut microbial balance

Inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, is characterized by chronic intestinal inflammation, disruption of the mucosal barrier, and immune dysregulation. Recent evidence underscores the role of gut macrophages, microbiota, and proinfla...

Chinese herbal medicine (Yiqi Huayu Jiedu Decoction) combined with chemotherapy for preventing postoperative recurrence and metastasis in elderly gastric cancer patients: protocol for a multicenter, double-blind, randomized, placebo-controlled trial

Abstract Introduction Gastric cancer (GC) has a generally unfavorable prognosis. Elderly patients often tolerate dual-drug chemotherapy poorly, experience limited benefits from monotherapy, and face high rates of postoperative recurrence and metastasis. To address this unmet clin...

Cryo-EM structures of Cdr1 reveal snapshots of substrate transport and diverse inhibitor recognition

In Candida albicans —a World Health Organization fungal priority pathogen—overexpression of the adenosine triphosphate (ATP)–binding cassette transporter Cdr1 drives multidrug resistance. We present seven cryo–electron microscopy structures capturing substrate entry and expulsion...

Deep Neural Network Enabled Complex‐Amplitude Metasurfaces for Simultaneous Nanoprinting and Holography

ABSTRACT Metasurfaces offer a compact and scalable platform for multidimensional optical field manipulation and engineering. By judiciously designing subwavelength scatterers to tailor the complex transmitted field, a single metasurface can encode a prescribed near‐field distribu...

Correlation between maternal serum pgRNA levels during pregnancy and neonatal virological characteristics at birth in HBV-infected pregnant women

To investigate the relationship between serum pregenomic RNA (pgRNA) in pregnant women with chronic HBV (CHB) infection during pregnancy and maternal clinical characteristics, virological characteristics of newborns at birth, and mother-to-child transmission (MTCT) outcomes. 312...

Metabolic Tumor Area: A Clinically Practical Prognostic Marker for Improved Risk Stratification in IPI Non‐High‐Risk DLBCL

ABSTRACT Metabolic tumor volume (TMTV) is a core 18 F‐FDG PET/CT prognostic marker for diffuse large B‐cell lymphoma (DLBCL), but its complex measurement and limited standardization restrict clinical utility. Metabolic tumor area (MTA) features simple operation and good reproduci...

Joint association of estimated glucose disposal rate and physical activity with cardiovascular disease incidence in patients with cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study based on the CHARLS database

Cardiovascular-kidney-metabolic (CKM) syndrome is a new concept proposed by the American Heart Association (AHA) that emphasizes the complex relationship between kidney disease, heart disease and metabolic factors. Many studies have shown that insulin resistance (IR) in CKM syndr...

Early gastric carcinoma with lymphoid stroma associated with a low risk of lymph node metastasis and favorable prognosis: a multicenter study in a Chinese population

Abstract Objective Gastric carcinoma with lymphoid stroma is a rare subtype of gastric carcinoma. The clinicopathological features and prognosis of early gastric carcinoma with lymphoid stroma (EGCLS) remain elusive, especially in Chinese populations. Methods In this study, we in...

Latent profiles of perceived digital convenience and their associations with depressive symptoms among Chinese empty-nest older adults: evidence from the 2023 CLASS

Digital technology is increasingly discussed as a potential resource for supporting mental health in later life, yet empirical findings remain mixed. Prior studies have largely relied on variable-centered approaches that may obscure how perceived convenience of digital activities...

The Effects of Acupuncture at Shuigou (GV26) on Patients With Disorders of Consciousness: An EEG Nonlinear Dynamics Analysis

Background Disorders of consciousness (DOC) lack objective biomarkers. We evaluated the immediate cortical effects of acupuncture at Shuigou (GV26) in DOC patients using nonlinear EEG parameters: approximate entropy (ApEn), Lempel–Ziv complexity (LZC), correlation dimension ( D 2...

Anticancer effects of an XPO1 inhibitor (selinexor) with sotorasib following omeprazole preconditioning in KRAS G12C-mutant non-small cell lung cancer cells in vitro and in a mouse tumor xenograft

BACKGROUND: KRAS G12C-mutant advanced non-small cell lung cancer (NSCLC) is currently treated with KRAS G12C covalent inhibitors, such as sotorasib, or RAS (ON) G12-selective inhibitors; however, response rates and progression-free survival remain limited, with recurrence occurri...

Remote electroacupuncture conditioning protects the heart via fine-tuning the dual role of the SDF-1α/CXCR4 axis in myocardial ischemia–reperfusion injury

BACKGROUND: Remote electroacupuncture (EA) conditioning on forearm protects against myocardial ischemia-reperfusion injury (MIRI). However, the cardioprotective mechanisms of RIC have not been fully elucidated. This study aimed to investigate whether EA could balance the pro-surv...

Occlusion-Robust Cattle Pose Estimation for Precision Livestock Monitoring Using Hierarchical Locality Refinement

Accurate cattle pose estimation is important for precision livestock farming because body landmarks can provide quantitative visual inputs for potential health monitoring, behavior analysis, lameness assessment, and welfare evaluation. This study focuses on keypoint-localization...

Fructose directly remodels the translocase of the outer membrane to impair oxidative phosphorylation in podocytes

Excessive dietary fructose consumption contributes to the rapidly increasing prevalence of obesity, metabolic syndrome, and chronic kidney disease worldwide, and accumulating preclinical evidence has confirmed that excess fructose exposure provokes severe mitochondrial dysfunctio...