Nanjing University of Chinese Medicine

Preclinical Evaluation of 68Ga-Labeled Heterodimers for Dual Integrin αvβ3 and PARP1-Targeted Tumor Imaging

Abstract Tumor heterogeneity limits the diagnostic performance of molecular imaging probes targeting a single biomarker. Here, we report the design, synthesis, and preclinical evaluation of 68Ga-labelled heterodimeric radiotracers co-targeting integrin αvβ3 and poly(ADP-ribose) p...

Predictors of clinical pregnancy after IVF in women with ovarian endometriomas: a propensity score-matched retrospective cohort study

Abstract Background Ovarian endometrioma (OMA) is associated with reduced in vitro fertilization (IVF) success rates. Therefore, the purpose of the study is to investigate risk factors associated with pregnancy outcomes following IVF in women with OMA and assess the predictive ut...

Using interpretable machine learning models to predict the occurrence of severe influenza in hospitalized children: a retrospective cohort study

BACKGROUND: Influenza, a prevalent disease, significantly threatens public health. Accurately predicting severe influenza occurrences is crucial for developing personalized prevention strategies and treatment plans. AIMS: This study aimed to construct a highly interpretable model...

Unsaturated Carboxylates as Electrophilic Synthons for Transition‐Metal‐Catalyst‐Free Electroreductive Deoxygenative Coupling

ABSTRACT The use of ester‐derived electrophiles in transition‐metal‐free electroreductive C(sp 3 )─C(sp 3 ) bond formation remains largely unexplored. Herein, we report a sacrificial‐anode‐enabled electroreductive cross‐coupling of simple unsaturated carboxylates with unactivated...

Unsaturated Carboxylates as Electrophilic Synthons for Transition‐Metal‐Catalyst‐Free Electroreductive Deoxygenative Coupling

ABSTRACT The use of ester‐derived electrophiles in transition‐metal‐free electroreductive C(sp 3 )─C(sp 3 ) bond formation remains largely unexplored. Herein, we report a sacrificial‐anode‐enabled electroreductive cross‐coupling of simple unsaturated carboxylates with unactivated...

An aging-informed multi-layer bioinformatics framework prioritizes GKN1 and PLAU/uPA-associated candidates in gastric cancer

Gastric cancer is molecularly heterogeneous. We used curated aging-gene annotation as a candidate-filtering prior, rather than as evidence of an aging mechanism, within an integrated bulk and single-cell bioinformatics framework. Differentially expressed genes in GSE29272 were in...

Distribution characteristics and risk factors of hidden blood loss in three posterior minimally invasive spinal fusions: a retrospective study of 158 patients

To investigate the perioperative blood loss distribution and independent risk factors for hidden blood loss (HBL) in three posterior minimally invasive lumbar interbody fusion techniques: minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF), unilateral biportal en...

Harnessing cell cycle synchronization to boost the therapeutic potential of umbilical cord MSCs against acute colitis

Abstract Human umbilical cord mesenchymal stromal cells (UCMSCs) are multipotent stem cells with strong immunomodulatory capacity, ease of acquisition, low immunogenicity, and a non-tumorigenic nature, making them attractive candidates for tissue repair. Under standard culture co...

Prediction of Claudin18.2 expression in gastric adenocarcinoma by habitat radiomics based on spectral CT

To explore the predictive value of habitat radiomics derived from Dual-layer spectral detector CT (DLSCT) for the preoperative evaluation of Claudin18.2 (CLDN18.2) expression in gastric adenocarcinoma. A retrospective cohort of 111 eligible patients with gastric adenocarcinoma wh...

Carotid intima thickness assessed using high-resolution ultrasound as a structural correlate of endothelial dysfunction

Purpose: This study evaluated the association between carotid intima thickness (cIT), measured using high-resolution ultrasound, and endothelial cell dysfunction (ECD), assessed using flow-mediated dilation (FMD), for early atherosclerosis risk assessment.Methods: Between January...

Exercise-associated transcriptomic profiling identifies Ticam2 as a candidate therapeutic target in a SOD1G93A mouse model of amyotrophic lateral sclerosis

Exercise may slow disease progression in amyotrophic lateral sclerosis (ALS), but the molecular mechanisms underlying its protective effects remain unclear. Here, voluntary wheel running prolonged survival in male SOD1 G93A mice. To identify potentially actionable molecular targe...

ViT-radiomics fusion for lymph node classification in ultrasound images: a multicenter study

Abstract Background Ultrasound (US) is widely used for assessing lymph node (LN) status, but its diagnostic accuracy remains highly operator dependent. A robust computer-assisted diagnostic model may enhance clinical performance and improve inter-operator and inter-center consist...

Self-assembled products from natural active compounds: mechanisms and applications in cancer therapy

Natural active compounds (NACs) possess diverse anticancer activities but are often limited by poor aqueous solubility, low bioavailability, insufficient tumor selectivity, and inadequate in vivo stability. Self-assembled products from natural active compounds (SAPNACs) provide a...

Lian-Jia-San-Jie formula suppresses non-small cell lung cancer via FTO-dependent m6A demethylation regulation of lncRNA CASC9 and its downstream CD3EAP

Background Dysregulation of the epitranscriptome is implicated in the aberrant expression of oncogenes during oncogenesis. In this study, we sought to elucidate the therapeutic mechanisms of Lian-Jia-San-Jie-Fang (LJSJF), a traditional Chinese medicinal formula composed of 14 her...

Platycodon grandiflorus –Derived Nanovesicles Sensitize Gastric Cancer to T Cell Killing via Ferroptosis‐Driven Membrane Mechanical Remodeling

ABSTRACT Plant‐derived nanovesicles have emerged as promising natural nanotherapeutics for cancer treatment, yet whether they can overcome the intrinsic resistance of tumor cells to cytotoxic T‐cell‐mediated killing remains largely unexplored. Here, we show that lipid‐enriched Pl...

Machine learning combined with multidimensional validation identifies SNCA and NR2F2 as key hubs implicated in paraquat and rotenone co-exposure-induced Parkinson’s disease

Combined exposure to pesticides, such as paraquat (PQ) and rotenone (Rot), is a significant risk factor for Parkinson’s disease (PD). However, the synergistic pathogenic mechanisms underlying their co-exposure remain largely elusive. This study aimed to elucidate the key molecula...

Formononetin attenuates skeletal muscle atrophy induced by gastric cancer cachexia

Formononetin (FMN) is a bioactive compound found in traditional Chinese medicinal plants, including red clover and Astragalus membranaceus. FMN has demonstrated anti-inflammatory effects and the promotion of myogenic differentiation. However, its role and precise mechanisms in mu...

Stabilizing Macrophage Immune States through Fusion-Enabled Nanoparticle-Based Intracellular Drug Depots for Durable Ulcerative Colitis Therapy

Abstract Ulcerative colitis (UC) is characterized by persistent colonic inflammation accompanied by the accumulation of pro-inflammatory M1-like macrophages, which sustain cytokine production and impair mucosal repair. Promoting a shift toward a pro-resolving M2-like phenotype is...

Global epidemiological discordance between GBD-defined biliary disease and pancreatitis reveals descriptive Pancreatitis Escape patterns with distinct exposure profiles

Background: Gallstone disease and pancreatitis are clinically linked, yet population-level estimates for GBD-defined gallbladder and biliary diseases are not a direct surrogate for gallstone pancreatitis risk. The global architecture of co-occurrence and epidemiological discordan...

The Vaginal Microbiome Across the Continuum from HPV Infection to Cervical Cancer: A Narrative Review

Persistent high-risk human papillomavirus (HR-HPV) infection serves as the core prerequisite for cervical intraepithelial neoplasia (CIN) and invasive cervical cancer. Accumulated translational evidence confirms that vaginal microecological homeostasis dominated by protective Lac...