Nanjing University of Chinese Medicine

A microbiota–substrate–metabolite–target network suggests AKT1-associated links between gut microbiota-derived metabolites and osteoporosis

OBJECTIVE: To build a computational, hypothesis-generating framework that links gut microbiota-related metabolites with osteoporosis (OP) while retaining upstream microbial source and substrate information, and to prioritize candidate host targets, pathways, and modules for subse...

Psoralen Suppresses Bladder Cancer Progression by Targeting AURKA: Inhibition of Proliferation and Promotion of Apoptosis

Background: Although psoralen is known for its antitumor and chemosensitizing effects across multiple malignancies, its function and molecular basis in bladder cancer (BC) remain insufficiently understood. Thus, this study examined its anti-cancer actions in BC and identified its...

Cascade Spirocyclization–Difunctionalization or Rearrangement of Bicyclobutyl-Tethered Aldehyde Hydrazones via Strain Release

Abstract A cascade spirocyclization–difunctionalization of bicyclobutyl-tethered aldehyde hydrazones with N-halosuccinimides was smoothly performed to access diverse halo-succinimide-containing diazaspiro[3.3]heptan-3-ones. Meanwhile, the three-component rearrangement of bicyclob...

Tetrandrine-loaded manganese-doped ceria nanozyme for nebulized inhalation therapy of the ROS-driven inflammatory-fibrotic continuum

Pulmonary fibrosis (PF) and acute lung injury (ALI) represent mechanistically interrelated stages along a shared inflammatory-fibrotic disease continuum, both driven by dysregulated macrophage responses and reactive oxygen species (ROS)-mediated signaling. Effective intervention...

Association between perioperative changes in complement levels and postoperative delirium in elderly patients undergoing hip or knee arthroplasty: a prospective cohort study

Postoperative delirium (POD) is a common postoperative complication in elderly patients undergoing major surgery, characterized by an acute disturbance of consciousness and cognition occurring within a short period after surgery. POD has substantial adverse effects on patient hea...

HSP90 shields ROC1/RBX1 from proteasomal degradation by CHIP E3 ubiquitin ligase to promote lung adenocarcinoma

The Regulator of Cullins 1 (ROC1) or RING box protein-1 (RBX1) is an essential component of the largest multiunit Cullin-RING ubiquitin ligase (CRL). Previous studies demonstrated that ROC1 is frequently overexpressed in multiple malignancies, which predicts advanced cancer stage...

Hsc70-Mediated Targeting Chimeras for Targeted Protein Degradation via Chaperone-Mediated Autophagy

Abstract Despite the remarkable success of proteolysis-targeting chimeras (PROTACs), challenges such as limited applicability to certain cytosolic proteins, potential resistance risks, and off-target effects remain. Novel degradation strategies harnessing the autophagy/lysosome p...

Effects of virtual team-based learning on nursing students’ learning outcomes: protocol for a systematic review and meta-analysis

Virtual team-based learning (VTBL) demonstrates considerable potential in nursing students’ education. However, its specific effects on theoretical knowledge, skills, competence, and satisfaction remain unclear. This study aims to evaluate the effectiveness of virtual team-based...

Co‐Assembled Helical Polymer Nanofibers Enable Efficient CO 2 Photoreduction Through Interchain Energy Transfer

ABSTRACT One‐dimensional (1D) nanofibers have shown bright prospects for artificial CO 2 photoreduction but still face formidable challenge in achieving high performance. Herein, a series of polymer nanofibers are prepared via the helical co‐assembly of chiral poly{1,2‐bis(4‐ethy...

Stimuli-responsive magnetic black phosphorus-based nanoreactor for chirality-dependent anoikis induction in cancer therapy

Anoikis presents an alternative scheme for suppressing tumor metastasis. While limited by off-target effects, rapid degradation, and reactive oxygen species (ROS) accumulation, anoikis resistance remains a persistent challenge for current tumor therapy. The use of external and en...

Targeting Tc17 cell differentiation via the IL-6/JAK1/STAT3 signaling axis to attenuate immune checkpoint inhibitor-related colitis and promote tumor immunity

Immune checkpoint inhibitor-related colitis (IRC) is one of the most common immune-related adverse events, yet its underlying mechanisms remain unclear and treatments lack precision targeting. This study aims to elucidate the immune cell infiltration characteristics and regulator...

Applications of large language models in anxiety and depression patient care: a cross-model comparative analysis of dialogue quality

The disease burden of anxiety and depression is becoming increasingly severe, and the shortage of mental health clinical resources restricts patients’ access to care services. Large language models offer a new pathway for digital psychological care, yet standardized horizontal co...

Learning curve for single-surgeon robot-assisted single-port extraperitoneal radical prostatectomy

To evaluate surgical outcomes of robot-assisted single-port extraperitoneal radical prostatectomy (E-sp-RALP) performed by a single surgeon and to characterize the procedural learning curve. Clinical data from 50 consecutive E-sp-RALP procedures performed at the Affiliated Hospit...

HMMR+ stromal cells drive human uterine development

Abstract Early uterine development in humans is a critical determinant of reproductive health and disease susceptibility during adolescence. While single-cell analyses have extensively characterized the adult uterus, the developmental origins of this organ remain poorly understoo...

Pachymic acid exhibits synergistic antitumor efficacy with lenvatinib in hepatocellular carcinoma by targeting PPARγ to inhibit glycolysis

Lenvatinib is a first-line treatment for hepatocellular carcinoma (HCC), though drug resistance may develop with long-term use. to investigate the potential of pachymic acid to enhance lenvatinib’s anti-tumor efficacy. HepG2 and LM3 cells were exposed to pachymic acid and/or lenv...

Tumor necrosis and ascites on baseline 18F-FDG PET/CT as independent prognostic imaging markers for double/triple-hit lymphoma.

OBJECTIVE: F-FDG) positron emission tomography/computed tomography (PET/CT) in DHL/THL patients. SUBJECTS AND METHODS: . RESULTS: =18.369, P<0.001, respectively) in subgroup analyses of patients treated with R-CHOP and intensive regimens, respectively. CONCLUSION: independently p...

Association between subjective well-being and the risk of cardiometabolic multimorbidity in older Chinese adults: effect modification by the integrated healthy lifestyle score

This study aimed to ascertain the association between subjective well-being (SWB) scores and the cardiometabolic multimorbidity (CMM) risk, and evaluate the potential modifying effect of integrated healthy lifestyle scores among older Chinese adults. A prospective cohort study wa...

Pharmacological inhibition of Alistipes putredinis-derived indole-3-acetic acid by baicalin suppresses stress-driven breast cancer metastasis

Breast cancer patients often experience chronic stress disorders and gut dysbiosis. Baicalin has been demonstrated to have antitumor, antibacterial and microbiota regulatory functions and can be used for treating breast cancer and preventing metastasis; however, how baicalin regu...

Intrinsic capacity, genetic susceptibility and incident inflammatory bowel disease: a prospective cohort study in UK Biobank

Abstract Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder, but whether intrinsic capacity (IC), a multidomain measure of functional reserve, is associated with incident IBD remains unclear. We analysed 427,489 UK Biobank participants free of IBD at baseline...

Characteristics associated with efficacy of hypoxia-inducible factor-prolyl hydroxylase inhibitors in renal anemia patients: a retrospective cohort study

Hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) are novel drugs used to treat renal anemia patients.However, their efficacy in elevating hemoglobin levels varies among patients. We aimed to identify characteristics that could influence hemoglobin level in renal...