Nanchang University

Vertical Control and Reduction of a Functional Mandibular Shift in Severe Class III Malocclusion With Unilateral Cleft Lip and Palate

Severe skeletal Class III malocclusion in repaired cleft lip and palate (CLP) may include fixed maxillary deficiency and a functional mandibular shift. A 15-year-old girl with unilateral complete CLP underwent staged nonsurgical treatment using posterior bite blocks, maxillary al...

Chromosome-Level Genome Assembly and Annotation of the Chinese Lizard Gudgeon (Saurogobio dabryi)

The Chinese lizard gudgeon (Saurogobio dabryi) is an economically important freshwater species within the Cyprinidae family, abundant in the middle and lower reaches of the Yangtze River and its adjacent basins. As a promising species suitable for aquaculture in China, the lack o...

Itaconate as a central node in immunometabolism and inflammatory control

Mitochondria serve as central regulators of cellular bioenergetics and inflammatory signaling, integrating metabolic status with immune responses. Disruption of mitochondrial homeostasis, including altered tricarboxylic acid cycle dynamics, redox imbalance, and aberrant reactive...

Root-System-Inspired Core–Shell Microneedles Enable Spatiotemporal Sequential Therapy via ROS Scavenging, Angiogenesis, and Capillary-Driven Lipid Removal for Enhanced Fat Graft Survival

Abstract Background Autologous fat grafting is widely used in reconstructive and aesthetic surgery, but its clinical outcomes are limited by early ischaemia–hypoxia, oxidative stress, delayed vascularization, and subsequent lipid accumulation-induced inflammation. Current therape...

Optimizing plasma-derived small extracellular vesicle purification to enhance downstream applications

Small extracellular vesicles (sEVs) are functional carriers of biomolecules from host cells, making them highly suitable for early disease diagnosis and monitoring disease progression. However, the purification of sEVs from plasma is complicated by the presence of high levels of...

Synergistic Heterointerface Engineering and Light‐Assisted Enhancement in NiSe/SnSe Anodes for Ultra‐Stable and High‐Rate Sodium‐Ion Batteries

ABSTRACT Sodium‐ion batteries (SIBs) face challenges from sluggish kinetics and volume expansion due to the large Na + radius. Herein, we design a carbon‐coated porous NiSe/SnSe@NC Schottky heterojunction via in‐situ synthesis. The epitaxial growth ensures lattice matching, estab...

Functional Specializationof Cellular and ExtracellularFractions of Bacteroides thetaiotaomicron Contributes to Glycan Utilization

Bacteroides thetaiotaomicron (Bt) degrades dietary glycans via carbohydrate-active enzymes (CAZymes), but their spatial distribution and functional coordination remain unclear. In this study, we characterized the "labor division" during glycan degradation across four bacterial fr...

Copper-Catalyzed Ring-Opening of N -Chlorocyclopropylamides for Modular Access to γ -Functionalized Enamides

Abstract Enamides are privileged structural motifs in pharmaceuticals, natural products, and synthetic intermediates. However, general and modular methods for accessing highly functionalized allylic enamides remain limited. Herein, we report a copper-catalyzed ring-opening functi...

Vaccinia-related kinase 2 confers pancreatic cancer with gemcitabine resistance through TPI1-driven aerobic glycolysis

Abstract Gemcitabine(GEM)-based chemotherapy is considered the first-line regimen for pancreatic cancer(PC), but the poor responsiveness and chemoresistance greatly limit its application. Metabolic reprogramming, especially aerobic glycolysis, which is regulated by glycolytic enz...

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

ABSTRACT Sexual fate in vertebrates is generally considered developmentally fixed; however, teleost fishes exhibit remarkable flexibility in their reproductive systems. It remains unclear whether a fully differentiated gonochoristic vertebrate can undergo complete and functional...

The spatial effects and influencing mechanism of digital infrastructure on urban-rural industrial integration in China

Digital infrastructure (DI) and urban-rural industrial integration (URII) are crucial for promoting economic efficiency and balanced regional development. However, the mechanism by which DI affects URII remains unclear, potentially leading to inefficient resource allocation, redu...

Effects of Pretreatment Temperature on Ni/CeO 2 Catalysts for Low‐Temperature CO 2 Hydrogenation

ABSTRACT Metal–support interaction (MSI) plays a key role in the intrinsic properties of catalysts and related catalytic performance, and it is crucial to explore the correlation between the performance and MSI. Herein, two series of Ni/CeO 2 catalysts were synthesized, and their...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Design Sensitivity as a Decision Tool for Incremental Urban Village Renewal: Weicun Village, Nanchang, China

Urban village renewal in China increasingly requires decision tools that can identify where incremental design intervention should be prioritized. However, existing renewal practices often rely on experience-based judgment and lack a reproducible quantitative framework for compar...

Early Changes in Composite Insulin-Resistance Indices After Adjunctive Probiotic Treatment in Olanzapine-Treated Schizophrenia: A Longitudinal Secondary Analysis

Objective Olanzapine is effective for schizophrenia but commonly causes metabolic dysregulation. This study examined whether adjunctive probiotic treatment was associated with short-term changes in composite insulin-resistance-related indices during olanzapine therapy. Methods Th...

Solute carrier family 25 member 32 promotes the proliferation of esophageal squamous cell carcinoma and is associated with immune infiltration

Abstract Esophageal squamous cell carcinoma (ESCC) is a highly invasive and poorly prognosed malignant tumor of the digestive tract. Currently, there are no effective molecular classification markers for ESCC. This study screened out the key gene SLC25A32 based on mitochondrial-r...

Effect of Delivery Tube Diameter on Melt Breakup and Powder Refinement During Water Atomization of FeSiCr Alloy Powder

Water atomization is widely used for producing FeSiCr alloy powder, in which melt delivery conditions strongly influence jet breakup and powder refinement. In this study, a coupled volume of fluid-discrete phase model (VOF-DPM) was established to investigate the effect of deliver...

CCL2 in Rheumatoid Arthritis: A Context-Dependent Cross-Cellular Node Serving as Biomarker and Therapeutic Target

C-C motif chemokine ligand 2 (CCL2) interacts with cytokines, adipokines, miRNAs, and multiple synovial cell populations. Experimental studies indicate that these interactions can form a CCL2-associated inflammatory amplification network across cell types. In cellular and animal...

PIGU expression is associated with poor prognosis and estimated immune cell infiltration in breast invasive carcinoma

Breast invasive carcinoma (BRCA) is a major cause of cancer-related mortality in women. PIGU , a subunit of the GPI-anchor biosynthesis complex, has been reported to be dysregulated in several cancers; however, its prognostic value and immune-related associations in BRCA remain u...

Pop Rocks-Inspired Bubble Driven Exosome Propulsion via Microneedles for Synergistic Wound Healing

Abstract Chronic nonhealing wounds remain a critical clinical challenge due to persistent bacterial infection, tissue hypoxia, and impaired cellular regeneration. Herein, inspired by the “popping” mechanism of Pop Rocks candy, we developed a multifunctional microneedle (MN) patch...