Nanchang University

METTL3-mediated m6A modification of circNOTCH2 attenuates osteogenic impairment of PDLSCs in inflammatory microenvironment via the MiR-193b-3p/KCNJ2/NLRP3 axis

<title>Abstract</title> The authors have requested that this preprint be removed from Research Square due to a pending patent application.

A Visual Detection and Multi-Zone Personnel Safety Control Method for Firework Manufacturing Workshops

Real-time visual detection is essential for personnel safety control in firework manufacturing workshops, where inadequate personnel-count control can increase safety risks in hazardous production zones. This study proposes a visual detection and multi-zone personnel safety contr...

Real-world evidence of self-managed weight loss enhancing skeletal muscle rate in individuals with overweight/obesity via mHealth app

Weight loss is essential for obesity management but may be compromised by skeletal muscle loss. This study evaluated the increase in skeletal muscle rate (SMR) and fat loss among individuals with overweight/obesity who achieved weight loss through self-management using a mobile h...

Dislocation StructureTransformation of (111) TwistGrain Boundaries in Silicon

Abstract Grain boundaries (GBs) play a crucial role in determining the performance of nanocrystalline and polycrystalline silicon. In this paper, we investigate the structural transformation of silicon (111) twist GBs through hybrid molecular statics (RBTs method, namely, the rig...

Pan-retinal pathology detection in oct scans integrating natural language synthesis with diagnostic annotation

Abstract While OCT is pivotal for macular disease diagnosis, its adoption in primary care is limited by AI systems that cannot simultaneously analyze multi-sectional scans across the full spectrum of maculopathies or generate diagnostically integrated reports. Here we present iOC...

Queen loss fails to elicit physiological and transcriptional responses in workers of the invasive garden ant Lasius neglectus.

Colonies of insects with morphologically distinct castes have been called superorganisms because the function of their queens and workers is analogous to the germline and soma in metazoan bodies. In the case of formicoid ants, workers typically have lost the sperm storage organ,...

HE-referenced eosinophil assessment and cutoff estimation using Congo red and Chromotrope 2R staining in chronic rhinosinusitis with nasal polyps

Abstract This cross-sectional histopathological study aimed to compare eosinophil visualization and quantification using Congo red, Chromotrope 2R, and conventional hematoxylin–eosin (HE) staining in chronic rhinosinusitis with nasal polyps (CRSwNP), and to explore HE-referenced...

Experimental Investigation of Flexural Performance of Prestressed Precast Hollow-Core Slabs with Foam Inserts and Wet Joints

This study introduces a novel prestressed precast hollow-core slab system with integrated polystyrene foam inserts and a spliced design utilizing cast-in-place wet joints, aiming to resolve the inherent trade-off between self-weight reduction and load-bearing capacity in precast...

Identification of pyroptosis-related hub genes and construction of a diagnostic model for acute liver failure based on integrated bioinformatics and machine learning

Acute liver failure (ALF) is a life-threatening syndrome marked by massive hepatocyte loss and dysregulated inflammation. Although pyroptosis, an inflammatory mode of programmed cell death, is thought to contribute to ALF pathogenesis, its exact role has yet to be fully defined....