Nanchang University

Protein Glutamylation: From Cytoskeleton to Signaling

ABSTRACT Protein glutamylation is a reversible post‐translational modification (PTM) that involves the enzymatic addition of glutamate moieties to, and their removal from, target proteins, thereby modulating their activity, stability, localization, and molecular interactions. Ini...

RetiWave-Mamba: a dual-stream network for retinal disease detection based on multi-scale context and feature-adaptive Mamba projection

Retinal diseases are a leading cause of irreversible vision impairment, making early and accurate diagnosis essential for effective treatment. Optical Coherence Tomography (OCT) serves as a critical imaging modality for this purpose, yet its automated analysis is hindered by inhe...

Constitutional mismatch repair deficiency presenting with six primary malignancies over nearly 8 years: a case report

Constitutional mismatch repair deficiency (CMMRD) is a rare cancer predisposition syndrome typically manifesting in early childhood. We report an atypical, adult-onset case of CMMRD in a 26-year-old female harboring a homozygous PMS2 germline nonsense mutation (NM_000535.7:c.1738...

Emerging frontiers in targeted and immunotherapeutic strategies for marginal zone lymphoma

Marginal zone lymphoma (MZL) comprises a heterogeneous group of indolent B-cell non-Hodgkin lymphomas. Most patients have favorable outcomes, but approximately 20% develop early relapse or progression within 24 months. Advances in molecular profiling have identified recurrent alt...

Immune–metabolic heterogeneity and prognostic associations in breast cancer: development of an eight-gene risk model and preliminary functional characterization of NAT2

Abstract Breast cancer is highly heterogeneous, and immune–metabolic interactions within the tumor microenvironment may contribute to differences in clinical outcome. In this study, transcriptomic, clinical, and somatic mutation data from TCGA-BRCA were analyzed, and the prognost...

Association of alternative Mediterranean diet score with the prevalence of hypertension among the US adults

Our study endeavors to explore the relationship between the alternative Mediterranean diet score (aMED), a tool for assessing adherence to the Mediterranean diet, and the prevalence of hypertension in the US population. An analysis was performed using the dataset from the Nationa...

A Multi-Variety Co-Expression Network Identifies Candidate Genes Associated with Tuber Color, Starch Composition and Texture in Greater Yam

Greater yam (Dioscorea alata L.) is a globally distributed yam species with high agronomic potential but variable culinary quality. The molecular basis of key tuber quality attributes, including flesh pigmentation, starch and sugar composition, texture after cooking, and moldabil...

Revitalizing Retired LiCoO2 Cathodes for High-Voltage Endurance via a One-Step Synergistic Upcycling

Abstract Current demands for recycling retired cathode materials and developing high-energy-density lithium-ion batteries inspire the possible conversion of end-of-life LiCoO2 (LCO) streams into next-generation high-voltage cathode materials. In this work, we demonstrate a one-st...

Intermittent Self-Triggered Fixed-Time Secure Consensus for Disturbed MASs Under False Data Injection Attacks

This paper investigates the fixed-time secure consensus problem for disturbed multi-agent systems (MASs) subject to false data injection attacks (FDIAs) via intermittent dynamic event/self-triggered control. To mitigate the impact of the FDIAs, a Nussbaum-based controller is desi...

MFSD2A in health and disease: lysolipid transport, barrier physiology, and translational boundaries

Abstract Major facilitator superfamily domain-containing protein 2A (MFSD2A) is a sodium-dependent lysolipid transporter that delivers lysophosphatidylcholine-bound fatty acids, particularly docosahexaenoic acid, across specialized cellular interfaces. This Review synthesizes str...

Identification and Experimental Validation of PANoptosis Key Genes for Constructing a PANoptosis Risk Diagnostic Model in Intervertebral Disc Degeneration

BACKGROUND: Intervertebral disc degeneration (IDD) represents a significant health concern globally. This study aimed to identify the PANoptosis key genes (PKGs) associated with IDD and construct a risk diagnosis model METHODS: Single-cell sequencing, machine learning algorithms,...

Hypoxia-inducible factor as a master switch in ocular neovascularization: overcoming anti-VEGF resistance and exploring therapeutic prospects

Abstract Hypoxia-inducible factor (HIF) is a key driver of ocular neovascular diseases. We systematically discuss its regulatory mechanisms and pathological roles in diabetic retinopathy (DR), retinopathy of prematurity (ROP), and neovascular age-related macular degeneration (nAM...

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

ABSTRACT To overcome the poor bioavailability and environmental instability of physical polyphenol co‐assemblies while maximizing their preventive efficacy, the authors engineered carrier‐free, metal–phenolic coordination nanoparticles (ZnCA NPs) utilizing divalent zinc (Zn 2+ )...

Distinct neuronal subpopulations in the anterior pretectal nucleus contribute to nitroglycerin-induced cephalic and extracephalic mechanical hypersensitivity

Abstract Background Chronic migraine is characterized by recurrent headache and persistent pain hypersensitivity, often accompanied by sensory symptoms such as photophobia. Although central sensitization within thalamic and brainstem circuits is thought to contribute to migraine...

Leveraging explainable artificial intelligence and satellite time-series for unravelling nonlinear environmental drivers of post-wildfire vegetation recovery

Understanding post-wildfire vegetation recovery is critical for ecological restoration under climate change. Using the severe March 2024 Yajiang forest fire in China's alpine ecosystem as a case study, we integrated time-series forecasting with interpretable machine learning, aug...

FC-Transformer multiple features fusion for predicting porosity and ILSS in CFRP autoclave processing

Curing pressure plays a critical role in controlling void evolution and improving the manufacturing quality of carbon fiber-reinforced polymer (CFRP) composites during autoclave processing. To gain deeper insight into this pressure–void relationship, a theoretical void-growth equ...

Potential role of ZG16 overexpression in malignant behaviors and macrophage phagocytosis in vitro

Despite extensive research, the key molecular regulators driving Colorectal Cancer (CRC) progression remain poorly defined. We analyzed bulk RNA sequencing (RNA-seq) data from The Cancer Genome Atlas (TCGA) database to assess ZG16 expression, Gene Set Enrichment Analysis (GSEA),...

Influence of Solidification Microsegregation on Heterogeneous Austenite Grain Growth in Nb–Ti Microalloyed Steel: Experimental Investigation and Phase-Field Simulation

To elucidate austenite grain coarsening and mixed-grain formation in continuously cast Nb–Ti microalloyed steel during high-temperature holding, high-temperature holding experiments, Clyne–Kurz microsegregation calculations, Thermo-Calc equilibrium precipitation analysis, Gladman...

Deoxygenation upgrading of pine pyrolysis oil over H-X zeolite/carbon composite catalysts derived from coal gasification fine slag

Integrating biomass energy development with solid waste utilization supports sustainable development. Against this backdrop, low-cost and efficient Na-X zeolite/carbon composite catalysts were developed from coal gasification fine slag(CGFS) through acid leaching, alkali-fusion a...

Genetic transformation of Pinus elliottii: Association of SPX3 with coordinated nitrogen-phosphorus metabolism and antioxidant defense

The lengthy breeding cycle of Pinus elliottii Engelm., an economically important conifer widely cultivated in southern China, and the inherently low transformation efficiency of conifers present major obstacles to genetic improvement. To address these challenges, an Agrobacterium...