Nanchang University

Oxeiptosis-Associated Molecular Subtyping and Immune Microenvironment Heterogeneity in Osteoarthritis

Background: Oxeiptosis is a ROS-induced, caspase-independent form of regulated cell death, but its role in osteoarthritis (OA) remains largely unexplored. This study aimed to identify oxeiptosis-associated molecular markers in OA synovium and establish an oxeiptosis-based molecul...

Machine Learning-Guided Discovery of Natural BACE1 Inhibitors with Enzymatic and Cellular Validation

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by excessive accumulation of β-amyloid (Aβ) peptides in the brain. Beta-secretase 1 (BACE1), the rate-limiting enzyme in the amyloidogenic processing pathway of amyloid precursor protein (A...

A study protocol of multicenter randomized controlled trial comparing three cannulated screws and dynamic condylar screw with medial anatomical buttress plate in treating old femoral neck fracture

Currently, there is no standardized consensus regarding hip preservation strategies for managing old femoral neck fractures. Our previously developed technique, utilizing a dynamic condylar screw (DCS), medial anatomical buttress plate (MABP), and iliac bone grafting (IBG), has b...

Deubiquitinase USP48 Promotes Gastric Cancer Peritoneal Metastasis by Stabilizing S100A9 to Drive Neutrophil Extracellular Traps Formation

ABSTRACT Peritoneal metastasis (PM) represents the primary cause of death in patients with advanced gastric cancer (GC), yet its underlying mechanisms remain poorly understood. Neutrophil extracellular traps (NETs) have emerged as key mediators of tumor progression, but how cance...

Design and Synthesis of Highly Stable N2O2-Type Azadipyrromethene NIR-II Dyes

Abstract N2O2-type azadipyrromethenes represent an important class of near-infrared (NIR) dyes that typically exhibit absorption below 900 nm. It is of great significance to extend their absorption beyond 900 nm. In this work, eight N2O2-type Zn (II)/Ni (II) azadipyrromethene NIR...

Kinetic-Controlled Ultrafast Synthesis of Ordered Intermetallic Nanoparticles

Abstract The disorder–order transition of metal alloys delivers ordered intermetallic nanoparticles (NPs) as efficient and stable catalysts. However, this transition is practically challenging due to the thermodynamically low driving force and the complex kinetic competition with...

Electrochemical/pH Dual-Responsive Smart MOF-Based Gated Sensor for Fluorescence Detection of Acetylcholinesterase Activity

Abstract It is still difficult for conventional gated sensors to be applied in practical scenarios because of formidable challenges, including complex preparation, premature leakage, protracted response, and low sensitivity and accuracy. Herein, we present a novel design strategy...

Phys-AbGAT: A Physics-Informed Multi-Task Graph Attention Network for Robust Antibody-Antigen Binding Affinity Prediction

Abstract Motivation Accurate prediction of antibody-antigen binding affinity is essential for therapeutic antibody design. Existing methods often model the dissociation constant (KD) and Gibbs free energy (ΔG) independently, overlooking their thermodynamic relationship and comple...

An interpretable fecal microbiota-based GBM-SHAP machine-learning model for distinguishing ankylosing spondylitis from healthy controls

Previous studies have identified associations between ankylosing spondylitis (AS) and the gut microbiota. This retrospective secondary analysis aimed to develop and interpret a fecal microbiota-based machine-learning model for distinguishing AS samples from healthy-control sample...

Fibroblast growth factor 21 is linked to ambient temperature-dependent regulation of pathological cardiac hypertrophy in UCP1 knockout mice

Adipocytes play an important role in the regulation of cardiovascular health and disease. However, the molecular mechanisms underlying the endocrine role of brown adipose tissue (BAT) in pathological cardiac remodeling remain unclear. Herein, we show that uncoupling protein 1 (UC...

Endoscopic Retrograde Appendicitis Therapy Versus Laparoscopic Appendectomy for Acute Appendicitis: A 10-Year Single-Center Retrospective Cohort Study

INTRODUCTION: Endoscopic retrograde appendicitis therapy (ERAT) is a minimally invasive, organ-preserving treatment for acute appendicitis (AA), but comparative evidence with laparoscopic appendectomy (LA) remains limited.​. METHODS: We retrospectively analyzed 450 patients with...

Differentiation of clear cell and non clear cell renal cell carcinoma through high-frame-rate contrast-enhanced ultrasound

To evaluate the value of high-frame-rate contrast-enhanced ultrasound (H-CEUS) in differentiating between clear cell renal cell carcinoma (ccRCC) and non-clear cell renal cell carcinoma (nccRCC). A retrospective study was conducted on 84 patients diagnosed with CCRCC and 28 patie...

An interpretable deep learning model based on enhanced CT predicts the recurrence of non-muscle-invasive bladder cancer within 2 years

Accurate risk stratification for non-muscle-invasive bladder cancer (NMIBC) recurrence is essential for personalized treatment. This study aimed to develop and validate a contrast-enhanced computed tomography (CT)-based model for predicting postoperative NMIBC recurrence within t...

Advances in Confined Catalysts for Methane Dry Reforming: From Design Strategies to Reaction Mechanisms

Abstract Dry reforming of methane (DRM) converts two major greenhouse gases, CH4 and CO2, into syngas. The products (CO and H2) can be directly utilized as feedstock for chemical processes such as Fischer–Tropsch synthesis and methanol production. Transition metal-based catalysts...

The relationship between biological rhythm disturbances and mixed features in major depressive episodes: a multicenter cross-sectional study

Major depressive episodes (MDEs) with mixed features are associated with greater clinical complexity and may represent an important indicator of bipolarity. Biological rhythm disturbances have been implicated in mood disorders, but their relationship with mixed features during MD...

A Dual-Key Lock Strategy for Bright Fluorescent Proteins Fabrication via Synergistic Noncovalent Activation of Aggregation-Induced Emission Luminogen

Abstract The development of simple, bio-friendly strategies to engineer bright fluorescent proteins (FPs) is crucial for biosensing and bioimaging. Conventional synthesis of FPs requires time-consuming chromophore maturation and tedious preparation, while covalent conjugation met...

An ESG-Based Assessment Framework for Project Governance in Expressway Construction Projects

Against the backdrop of the global pursuit of sustainable development, the traditional governance model for expressway projects, which prioritizes economic returns, can no longer meet contemporary sustainability requirements. Drawing on stakeholder theory and sustainable developm...

Nickel-Catalyzed Strain-Release Alkyl–Alkyl Cross-Coupling of N -Chlorocyclopropamides with Tertiary α-Bromo Esters

Abstract We report a nickel-catalyzed alkyl–alkyl cross-electrophile coupling of N-chlorocyclopropamides with tertiary alkyl bromides. This method leverages cyclopropane strain release to generate alkyl radicals via β-scission of nitrogen-centered radicals, enabling efficient C(s...

Isoform Ratio Rather than Total Content Determines Nonlinear Bioactivity of Red Kidney Bean Phytohemagglutinin in Mice

Abstract Red kidney bean phytohemagglutinin (PHA) is an isolectin system of erythroagglutinating (PHA-E) and leucoagglutinating (PHA-L) subunits, but the biological significance of the natural ratio remains unclear. Here, natural PHA fractions with stepwise PHA-E/PHA-L ratios (N1...

Flavor quality evaluation and discrimination of regional tea (Camellia sinensis L.) based on metabolomics, volatileomics, and machine learning

This study aimed to elucidate the differences in the composition of the flavor molecular basis of fresh tea leaves ( Camellia sinensis L.) from different regions and their potential for geographical discrimination. The samples from eight representative producing areas across Chin...