Nanchang University

Analytical model for the progressive collapse resistance of a novel fully assembled concrete beam‐column substructure with bolted flange connections

Abstract This study develops an analytical model to characterize the progressive collapse resistance of a novel fully assembled concrete beam‐column substructure with bolted flange connections. The model, which idealizes the bolts as an equivalent continuous section to determine...

Multi‐Omics Genome‐Wide to Explore the Formation and Development Targets for Intracranial Aneurysms

Intracranial aneurysms (IAs) represent a significant and potentially life-threatening category of disease, and there is currently a lack of effective treatment options aimed at preventing the progression of the disease. Accordingly, this study is dedicated to exploring and identi...

The Translocation of Circular DNA with Variable Single/Double Strand Ratios through Solid-State Nanopores: Transition from Entropic Barriers to Crowding-Dominated Kinetics

Solid-state nanopores serve as powerful single-molecule analytical platforms for characterizing the physicochemical signatures of nucleic acids and proteins, yet prior work has focused almost exclusively on linear DNA, leaving circular DNA translocation poorly understood, particu...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

Mitochondria–endoplasmic reticulum contacts as signaling platforms in chondrocyte homeostasis and osteoarthritis: from adaptive coupling to pathological amplification

Osteoarthritis (OA) is a progressive whole-joint disease in which cartilage degeneration remains a central pathological event. Mitochondrial dysfunction and endoplasmic reticulum (ER) stress are prominent features of chondrocyte dysfunction, but how these processes are coordinate...

Intergenerational support and risk of incident visual impairment among middle-aged and older Chinese adults: a national longitudinal cohort study

Abstract Background Visual impairment is a major contributor to functional decline and reduced quality of life among older adults. While biological and demographic factors are well established, the role of family-based social support remains unclear. In China, intergenerational s...

Integration of Multi-Omics Reveals Genomic Features of Chromatin Accessibility in Gardenia jasminoides J.Ellis Leaves

Chromatin accessibility is an important feature of cis-regulatory elements that shapes gene regulation in plants; however, it has been studied less frequently in traditional medicinal plants such as Gardenia jasminoides J.Ellis (G. jasminoides). This study applied Assay for Trans...

Topology Engineering Regulates Free Volume to Decouple Efficiency‐Mechanical Performance Trade‐Off in Intrinsically Stretchable Organic Solar Cells

ABSTRACT Intrinsically stretchable organic solar cells (IS‐OSCs) hold great promise for wearable electronics, yet their development is severely hindered by the trade‐off between efficiency and mechanical robustness, remaining a critical challenge. Herein, three polymerized small‐...

Prevalence and characteristics of colonic diverticulosis: a retrospective cross-sectional study in Southern China

Abstract Background Recent literature indicated that the prevalence of colonic diverticulosis in China is increasing. However, there is limited information on colonic diverticulosis in China. Our study aims to determine the prevalence and characteristics of colonic diverticulosis...

Beyond the Meta‐Analysis: Reconsidering Class Effects, Resistance Surveillance, and Dosing Optimization in Tegoprazan–Amoxicillin Dual Therapy

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

Investigation of Position-Dependent Signal Propagation Delay in Large-Pitch AC-LGAD Using a Two-Dimensional Transmission-Line Model

This paper presents a study of position-dependent signal propagation delay in large-pitch pixelated AC-coupled Low-Gain Avalanche Detectors (AC-LGADs). In AC-LGADs, a continuous resistive N+ layer and segmented AC-coupled readout electrodes enable charge sharing and simultaneous...

Conductive Network Evolution and Self-Sensing Mechanism of Carbon Fiber Asphalt Concrete Based on Electrical Impedance Spectroscopy

To overcome the problems of poor durability and structural incompatibility inherent in conventional urban traffic monitoring technologies, this study develops a self-sensing asphalt concrete composite incorporating carbon fiber (CF) as a conductive functional filler to construct...

miR ‐15a‐5p Regulates Ferroptosis in Glioblastoma by Targeting GLS2

ABSTRACT Aims Glioblastoma (GBM) remains the most lethal primary brain tumor, and the molecular mechanisms driving its aggressiveness are incompletely understood. Recent multi‐omics analyses have identified miR‐15a‐5p as one of the core microRNAs most closely associated with GBM....

PSMD14 reduced microglial M2 polarization to promote ferroptosis and aggravate traumatic brain injury through the induction of BMP6/SMAD3 pathway

The present study aimed to investigate the functional role of proteasome 26S subunit non-ATPase 14 (PSMD14) in traumatic brain injury (TBI) and further elucidate its molecular mechanisms linking ferroptosis to microglial M2 polarization. A total of 52 clinical samples from TBI pa...

Development and internal validation of an explainable machine learning model for predicting functional disability trajectories in hospitalized older patients with chronic low back pain

Functional disability poses a critical challenge to healthy aging in older patients with chronic low back pain (CLBP). However, understanding of heterogeneous functional disability trajectories in this population remains limited, and effective risk stratification tools are lackin...

Combined assessment of stress hyperglycemia ratio and frailty for mortality risk prediction in critically ill patients with coronary heart disease: insights from the MIMIC-IV database

Critically ill patients with coronary heart disease (CHD) are at high risk of early death. Traditional prognostic models may not fully capture the combined effects of acute metabolic stress and reduced physiological reserve. We hypothesized that integrating the stress hyperglycem...

A Cross-Sectional Study of Short-Video Viewing and Young Adult Health: Dose–Response Relationships with Sleep, Dream Anxiety, Ocular Surface, and Quality of Life

Background: Short-video platforms (e.g., Douyin, TikTok) have gained immense popularity among young adults, yet their addictive potential and health consequences remain understudied. Unlike gaming addiction, which has been linked to myopia and mental distress, short-video viewing...

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

ABSTRACT Butyrate (BA) is essential for intestinal health, but its intestinal therapeutic applications are hindered by its malodorous nature, premature gastric absorption, and rapid intestinal metabolism. To address these challenges, an inodorous macromolecule β‐glucan‐BA (GLU‐BA...

Initial Clinical Experience with Percutaneous Endocardial Septal Pulsed Field Ablation in Hypertrophic Obstructive Cardiomyopathy: A First-in-Human Case Series

Background: Pulsed field ablation is a nonthermal ablation modality with a potentially favorable tissue selectivity profile. However, its application in septal reduction therapy for hypertrophic obstructive cardiomyopathy remains unexplored clinically. We investigated the feasibi...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...