Nanchang University

Associations of genetically predicted Helicobacter pylori antibodies with aneurysmal subarachnoid hemorrhage and unruptured intracranial aneurysm

The causal relationship between Helicobacter pylori antibodies and the risk of cerebral aneurysms remains unclear. We used Mendelian randomization analysis to assess the causal relationship between Helicobacter pylori antibodies and the risk of cerebral aneurysms. A genome-wide a...

Nanoporous titanium implant functionalized with sustained strontium release orchestrates immune microenvironment for enhanced osseointegration

Objectives Insufficient osseointegration remains a major limitation of dental and orthopedic implants. This study aimed to develop a strontium-releasing nanoporous titanium surface (TDS) with improved interfacial stability and immunomodulatory capacity to promote implant osseoint...

Novel therapeutics for platinum-resistant ovarian cancer: from biological mechanisms to emerging biomarker-guided strategies

For decades, platinum resistance has remained one of the major barriers to improving outcomes in ovarian cancer. Patients with platinum-resistant ovarian cancer (PROC) generally have shorter overall survival and lower response rates to second-line treatment than those with platin...

Manganese Dioxide Modified Low-Temperature Pyrolytic Carbon Rich in Oxygen-Containing Functional Groups for Efficient Vanadium Ion Adsorption

Vanadium-bearing wastewater threatens aquatic ecosystems and human health, calling for efficient, low-cost adsorbents. In this study, low-temperature pyrolytic carbon rich in oxygen-containing functional groups is prepared from Camellia oleifera fruit shells (COS) and modified wi...

Synergistic urea-assisted activation and nitrogen doping of biomass-derived porous carbon from coconut shell for high-performance supercapacitors

Biomass-derived carbon offers a renewable and low-cost route for fabricating advanced carbon-based supercapacitors. In this study, a cost-effective biomass precursor, coconut shell, was used to successfully prepare nitrogen-doped porous carbon materials through a synergistic modi...

Study on the effect of nitriding gas on the direct nitridation of silicon swarf from the photovoltaic industry for synthesizing silicon nitride

In the process of diamond wire cutting silicon wafers in the photovoltaic industry, tens of thousands of tons of high-purity silicon swarf are generated. There is an urgent need for the recycling and utilization of silicon swarf. Current research lacks systematic studies on the p...

PNA-TPP treatment is associated with Drp1-related mitochondrial dysfunction and an enhanced response to cisplatin in A549-derived stem-like spheres

Cisplatin (CDDP) resistance reduces the treatment effect in non-small cell lung cancer. Lung cancer stem-like cells are closely linked to drug tolerance. Mitochondrial dysfunction may affect their stemness and response to treatment. This study examined whether peptide nucleic aci...

Synergistic Regulation of High Dielectric Constant and H‐Aggregation for Efficient and Thickness‐Tolerant Organic Solar Cells

ABSTRACT While the power conversion efficiency (PCE) of organic solar cells (OSCs) has advanced rapidly, their sensitivity with respect to active layer thickness hinders industrial fabrication. Herein, a novel acceptor BMD‐6F was synthesized via molecular engineering of L8‐BO, wh...

Synergistic Regulation of High Dielectric Constant and H‐Aggregation for Efficient and Thickness‐Tolerant Organic Solar Cells

ABSTRACT While the power conversion efficiency (PCE) of organic solar cells (OSCs) has advanced rapidly, their sensitivity with respect to active layer thickness hinders industrial fabrication. Herein, a novel acceptor BMD‐6F was synthesized via molecular engineering of L8‐BO, wh...

Probiotics modulate the interactions between gastric and intestinal microbiota after Helicobacter pylori eradication

Standard eradication therapy for Helicobacter pylori ( H. pylori ) induces substantial gastrointestinal dysbiosis. Here, we investigated whether probiotic supplementation mitigates these spatial microbial perturbations and facilitates ecological recovery post-eradication. C57BL/6...

Sustainable and Synergistic Energy Management for Large Model Computing

The rapid growth of foundation models, most prominently large language models (LLMs), is turning the electricity consumption of computing infrastructure into a first-order constraint on the artificial intelligence (AI) industry. This review synthesizes recent literature on three...

An integrated spatial-legal diagnosis of governance barriers to green corridor implementation in China’s Gan River Basin

Fragmentation of urban habitats necessitates governance that spatially aligns ecological requirements with legal structures. This study conducts a systematic diagnostic review of governance blockages to the establishment of a green corridor in China’s rapidly urbanising Gan River...

Four dietary flavonoids differentially modulate the gut microbiota–barrier interaction against colitis-driven cognitive deficits

Accumulating evidence links inflammatory bowel disease (IBD) to cognitive impairment driven by gut barrier disruption and dysbiosis via the gut-brain axis. Currently, the impact of dietary flavonoids on IBD-related cognitive deficits remains unclear. This study found that the sel...

Variable-Dimension Differential Evolution for Ring-Count-Optimized Sparse Concentric Ring Array Synthesis

This communication proposes a variable-dimension differential evolution (VDDE) algorithm for synthesizing uniform amplitude sparse concentric ring arrays (CRAs) with minimized peak sidelobe level (PSL). Different from conventional fixed-ring-count methods, the VDDE simultaneously...

How does climate risk affect fisheries? New evidence from the operating cash flows of Chinese listed firms

Listed fisheries companies depend heavily on natural conditions, leaving their operations particularly exposed to climate change. Using Chinese listed fisheries companies as the research sample, this study examines the effect of regional climate risk on operating cash flow and in...

Analysis of Oligopeptides from Pilose Antler Using Tandem Mass Tags Combined with Ultra-High-Performance Liquid Chromatography-Q-Orbitrap/Mass Spectrometry

Reports on oligopeptides derived from pilose antler remain scarce. There is an urgent need to establish a robust analytical method for detecting and characterizing these compounds. In this study, oligopeptide extracts from pilose antler were labeled with tandem mass tag (TMT) rea...

Glucomannan from Aloe vera Gel Strengthens Intestinal Barrier by Suppressing Macrophage M1 Polarization via the Lactic Acid–Piezo1–Ca2+ Axis

Abstract Modulating intestinal macrophage polarization is critical for maintaining intestinal barrier integrity. Our previous study demonstrated that glucomannan from Aloe vera gel (AGP) improved the intestinal barrier, yet its direct impact on intestinal macrophages remained und...

Targeting GGT1 via RGD-modified lipid nanoparticles suppresses breast cancer lung metastasis by disrupting exosome-mediated angiogenesis

Breast cancer lung metastasis remains a major cause of mortality, largely because effective treatment options are limited. In this study, we identify gamma-glutamyltransferase 1 (GGT1) as a factor associated with breast cancer lung metastatic progression. Analyses of clinical dat...

How Tension Persists: Perceptual Integration and Resistance in Architectural Form

‘Tension’ is common in formal analysis, yet it has rarely been explained at the level of mechanism. One account attributes it to a form’s deviation from a reference form. This paper instead asks whether the integration, in perception, of the parts of a form can be completed. Tens...

Timing of Vasopressin Initiation in Sepsis Patients on Norepinephrine: A Target Trial Emulation

Background The optimal timing for initiating vasopressin in septic shock remains uncertain, with conflicting evidence potentially arising from variations in patient severity and methodological limitations such as immortal time bias. This study aimed to evaluate the time-varying e...