McGill University Health Centre

Dietary Fat Intake and Mortality Among Patients With Nonmetastatic Prostate Cancer

Importance There are 3.5 million prostate cancer survivors in the US, with a need for evidence-based lifestyle recommendations that improve survivorship. Objective To assess whether consumption of specific dietary fats after diagnosis is associated with long-term survival among p...

Oxygen-dependent subcellular redistribution of PHD3 links the hypoxic microenvironment to mitochondrial metabolic reprogramming in ccRCC

Abstract Clear cell renal cell carcinoma (ccRCC) is characterized by profound metabolic dysregulation, with both prolyl hydroxylase domain protein 3 (PHD3) and pyruvate carboxylase (PC) independently implicated in disease progression. Although each influences patient outcomes, a...

International Society of Urological Pathology Multidisciplinary Expert Consultation Conference on Evaluation of Treatment Effects in Prostate and Bladder Cancer

Treatment effects in the urinary bladder are variable and range from localized post-transurethral resection changes to widespread systemic therapy effects. The International Society of Urological Pathology (ISUP) organized a consensus meeting in Vienna, Austria, in September 2025...

Blood-based biomarkers of Alzheimer’s disease and neurodegeneration in an indigenous African cohort using both Simoa and NULISA platforms

Background: In low- and middle-income countries, Alzheimer's disease and related dementias (ADRD) constitute a growing public health burden. Indeed, the lack of awareness and easy screening tools, such as blood-based biomarkers, leaves many patients undiagnosed. In this study, we...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Baseline gut microbiome and metabolome profiles predict weight loss after a structured lifestyle intervention

Abstract Background Obesity remains a global health challenge, and responses to lifestyle-based weight-loss interventions are heterogeneous. Here, we evaluate a one-year structured lifestyle program in 50 adults with obesity (mean BMI 42 ± 7.0 kg/m 2 ), integrating clinical, micr...

Group Sequential Design with Posterior and Posterior Predictive Probabilities

Group sequential designs drive innovation in clinical, industrial, and corporate settings. Early stopping for failure in sequential designs conserves experimental resources, whereas early stopping for success accelerates access to improved interventions. Bayesian decision procedu...

Catatonia in a 13-Year-Old With T-Cell Lymphoblastic Lymphoma Following Intrathecal Methotrexate

BACKGROUND: Methotrexate neurotoxicity is a recognized complication in pediatric lymphoid malignancies, presenting with seizures, stroke-like episodes, or leukoencephalopathy. Catatonia is a rare and underrecognized manifestation. OBSERVATION: A 13-year-old girl with T-cell lymph...

Species-specific prophage induction by ciprofloxacin in human gut metagenomes

ABSTRACT Antibiotics are known to trigger prophage induction in controlled laboratory settings, but it remains unclear whether this also occurs within microbiomes in nature. Current methods investigating the link between antibiotics and prophage induction within the human gut rel...

Osteosarcopenia Revisited: From Mechanisms to Management

Abstract Sarcopenia and osteoporosis are characterized by insufficient mass and function of skeletal muscle and bone, and often co-occur in older persons, a condition called osteosarcopenia. Loss of bone and skeletal muscle mass and function is driven by multiple risk factors tha...

A community-validated tool for clinical outcome calculation in multiple sclerosis: Consensus development and scenario-specific recommendations

Background: Reproducibility and comparability of disability outcomes remain major challenges in multiple sclerosis (MS) research. Definitions of disability progression vary widely across studies, and calculation criteria are often insufficiently documented to enable replication....

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic...

The Metabolic Revolution in Dermatology: Obesity, Insulin Resistance, and Ultra-Processed Diets as Drivers of Skin Inflammation

Inflammatory dermatoses are increasingly linked to systemic metabolic factors. Obesity and insulin resistance create a pro-inflammatory milieu that affects the skin. Adipose tissue functions as an endocrine organ secreting adipokines and cytokines that drive chronic inflammation...

Statistical methods, outcome structures, and research designs in hybrid type II effectiveness-implementation studies: protocol for a scoping review

<ns5:p>Background Hybrid type II effectiveness-implementation studies evaluate health intervention and implementation strategy effectiveness simultaneously. While the emphasis on each “side” varies within hybrid type II studies, the focus of this review is those that attempt a mo...

Introducing Mid‐Level Dental Providers in Iran: Challenges and Opportunities

ABSTRACT Objectives The WHO Global Strategy and Action Plan on Oral Health 2023–2030 encourages innovative approaches such as shifting tasks from dentists to Mid‐level Dental Providers (MLDPs), who work independently to improve access to and equity in oral health. This study aime...

Platform ecosystem governance and its influence on the process of formation and institutionalization of new practices for development

This study examined how platform ecosystem governance mechanisms, as enacted through human intermediaries, influenced the formation and institutionalization of new practices among smallholder farmers in an ICT4D context. We conceptualize platform ecosystems as socio-technical sys...

Exploring Immersive Virtual Reality as an Approach to Improve School Participation–Related Constructs in Children With ADHD

ABSTRACT Background School participation is frequency and involvement from person–environment transactions, not diagnosis, per the International Classification of Functioning, Disability and Health (ICF) and the family of participation‐related constructs (fPRC). In this framework...

PTPN1 and PTPN2 cooperatively set interferon responsiveness thresholds that govern cancer immune evasion

Immune evasion by cancer cells remains a major barrier to the success of immune checkpoint blockade (ICB). In recent years, Protein tyrosine phosphatase non-receptor type 2 (PTPN2) has emerged as a promising and druggable target for cancer immunotherapy. Small-molecule agents cur...

MRI‐based deep learning models match or surpass physician performance for early detection and staging of avascular necrosis of the femoral head: A systematic review

PURPOSE: Efficient and reliable magnetic resonance imaging (MRI)-based diagnosis of early avascular necrosis of the femoral head (AVNFH) is essential for guiding treatment but remains challenging due to variability in clinician experience. Deep learning (DL) models offer a promis...

A Scoping Review on the Evidence for Virtual Reality Simulation in Surgical Training

Objective Simulation has become a mainstay in surgical education as it is proven to improve trainees’ surgical skills. Virtual reality is a relatively new technology that allows for high-fidelity surgical simulation for many surgical procedures across many specialties. However, t...