McGill University Health Centre

Intratumoral and Peritumoral Functional Connectivity Reveals Network‐Level Signatures of Glioma

ABSTRACT Gliomas are recognized as network‐level diseases that remodel functional connectivity across the brain. Using resting‐state functional MRI (rs‐fMRI) data from 306 patients with pathologically confirmed glioma at two hospitals, we delineated individualized intra‐ and peri...

Mechanoadaptive nanowire viscoplastic composites with strain-enhanced conductivity for reprocessable bioelectronic interfaces

Bioelectronic interfaces must mechanically conform and adapt to biological tissues while maintaining stable electrical performance during motion and deformation. Existing soft conductors, however, often couple mechanical strain to electrical resistance, accumulate interfacial str...

Altered sperm DNA methylation provides an epigenetic route from overweight and older men to intergenerational disease transmission

The occurrence of childhood neurodevelopmental disorders has been steadily increasing for decades, yet we have little understanding of modes of inheritance implicated in these diseases. Epidemiology studies have revealed an association between an elevated paternal Body Mass Index...

Ultraprocessed Food Intake and Adiposity, Vascular Brain Injury, and Cognition in Middle-Aged Adults

Importance Ultraprocessed foods (UPFs) account for a substantial and increasing proportion of dietary intake in Canada. Although UPFs are consistently associated with adiposity and cardiometabolic disease, their associations with subclinical vascular brain injury (VBI) and cognit...

Slow Frontal Spindle Activity and Declarative Memory Retention During Daytime Naps

ABSTRACT Memory consolidation refers to how newly encoded memories are strengthened and retained over time, and ample evidence indicates that sleep supports this process for both procedural and declarative memories. Although sleep spindles during non‐rapid eye movement (NREM) sle...

Managing growth and puberty concerns in individuals with Duchenne muscular dystrophy: Updated guidance and future directions

Long-term glucocorticoid therapy is standard of care for individuals with Duchenne muscular dystrophy (DMD) but often results in impaired growth and delayed or incomplete puberty, impacting their physical and psychosocial health. Although DMD endocrine care has evolved, leading t...

Impact of Primary Health Care Reforms in Quebec’s Health Care System: A Systematic Review

Introduction: Primary health care (PHC) reforms in Quebec between 2000 and 2023 aimed to improve accessibility, continuity, efficiency, and equity through organisational transformation, notably the Family Medicine Groups (FMGs), centralised waiting lists (Guichets d’accès), the a...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

PTPN2 sustains non-canonical inflammasome activation and shapes the inflammatory response to sepsis

Abstract The innate immune system relies on pattern recognition receptors to recognize and detect pathogens. Gram-negative bacteria release LPS-rich outer membrane vesicles (LPS-OMVs), which activate PRRs, trigger inflammation at distant sites and contribute to systemic inflammat...

Congenital heart disease in adults: evolving health systems and lifelong outcomes.

Over the past decades, advances in the diagnosis and treatment of congenital heart disease have reshaped its epidemiology. Congenital heart disease is now increasingly a chronic, lifelong disorder, with adult survivors outnumbering affected children in many countries. This demogr...

Transarterial embolization in musculoskeletal care: an indication-stratified narrative review

Abstract Background Transarterial embolization (TAE) is increasingly used across a broad spectrum of musculoskeletal conditions, ranging from established hemostatic and tumor-related indications to emerging pain-directed procedures for degenerative joint disease and chronic infla...

A Contemporary Review of Resectability and Treatment Strategies for Colorectal Liver Metastases: Part 1—Diagnosis, Defining Resectability, and Management of Upfront Resectable and Synchronous Disease

Background/Objectives: Colorectal liver metastases (CRLMs) remain a major determinant of long-term outcome. Although hepatic resection offers the best chance of durable survival, the definition of resectability has evolved beyond technical feasibility alone. This review aims to p...

Mind the Gap: Disparities in Education on Organ Donation and Transplantation-Results of a Global Survey.

Background: Widely accessible education on organ donation and transplantation (ODT) is a tool to reduce waiting lists, as <10% of transplant needs are met (Global Observatory on Donation and Transplantation). We aimed to assess the current state of access to education on ODT worl...

Acceptance of Organs From Deceased Donors: Results of a Global Survey.

Background: With <10% of transplantation needs being met, one contributing factor may be the potential subjectivity in transplant specialists' acceptance of organs. Such decisions, if influenced by knowledge and/or comfort gaps, warrant intervention. We assessed knowledge and com...

Consensus-based clinical and research recommendations for use of glucagon-like peptide-1 receptor agonists in the context of eating disorders: a modified Delphi study.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes management and later expanded to obesity treatment, have shown preliminary efficacy in reducing binge eating episodes. However, the appetite-suppressing and weight-loss effects of GLP-1R...

AX-35 Targets the Cytochrome bc1 Complex in Mycobacterium abscessus and Reveals a Novel Resistance Mechanism

Abstract In patients with cystic fibrosis, nontuberculous mycobacteria are opportunistic, intracellular and extracellular pulmonary pathogens that contribute to deterioration of lung function and, ultimately, morbidity from respiratory failure. Among nontuberculous mycobacterial...

Non-invasive assessment of left atrial activation using lead V8 during Bachmann bundle pacing

Abstract Background and aims Bachmann bundle pacing (BBP) improves atrial synchrony by advancing LA activation, but quantifying inter-atrial synchronization remains challenging. This study evaluated whether lead V8 reflects posterolateral LA activation time and whether lead V8 ca...

Trained Immunity in Childhood Vaccination

Conventionally, vaccine design has focused on identifying antigens that induce durable T and B cell memory and provide long term protection against subsequent encounters with the same pathogen. Unconventionally, a growing number of epidemiological, preclinical, and clinical studi...

Spleen-derived circulating intercellular adhesion molecule 2 promotes osteosclerosis in chronic myelofibrosis

Abstract Mutations in the gene coding G6b-B, Mpig6b in mice, and MPIG6B in humans lead to myelofibrosis, progressive splenomegaly and osteosclerosis. Aberrant megakaryocyte function in bone marrow and spleen may affect bone cells through cell-cell contact or soluble factors. We a...

Back to economic fundamentals: a welfare-based accounting framework for societal value in health technology assessment

Practical adoption of “novel” value elements in value assessment remains uneven, in part because components are often defined inconsistently and may overlap. We develop a welfare-grounded accounting framework to organize societal value components and clarify when proposed element...