McGill University Health Centre

In vivo CRISPR screening identifies metastasis suppressors in triple-negative breast cancer

Metastatic cancer remains the leading cause of cancer-related mortality, yet tumor cell–intrinsic mechanisms restraining metastatic dissemination remain incompletely defined. Here, we perform an unbiased in vivo genome-wide CRISPR/Cas9 loss-of-function screen in a breast cancer x...

Acute respiratory distress syndrome in scrub typhus: a systematic review and meta-analysis

PURPOSE: Acute respiratory distress syndrome (ARDS) is an important complication of scrub typhus and is associated with substantial mortality. The primary objective of this systematic review and meta-analysis was to estimate the proportion of hospitalised patients with microbiolo...

A qualitative study on how and why families engage with diverse antenatal care systems in rural eastern Zimbabwe

Antenatal care (ANC) pluralism—meaning, pregnancy-related care and support drawing on local indigenous and biomedical forms of care—is essential to reducing pregnancy-related morbidity and mortality in culturally appropriate ways in sub-Saharan Africa. Yet, many current intervent...

Use of Hypnosis for Intra-Articular Steroid Injections in Children with Juvenile Idiopathic Arthritis

Objectives Intra-articular steroid (IAS) injections are a common treatment for Juvenile Idiopathic Arthritis (JIA) but can cause anxiety in children, particularly due to needle fear. To facilitate cooperation, general anesthesia is often used for younger children or those requiri...

Neonatal Point-of-Care Lung Ultrasonography: Techniques and Normal Findings

Point-of-care lung ultrasonography (POC-LUS) has become a routine bedside tool for evaluating respiratory status in many neonatal intensive care units. This article walks neonatologists through the fundamentals of its application-probe selection, system setup, and image acquisiti...