McGill University Health Centre

Determinants of complementary feeding practices – a qualitative study exploring mothers and fathers’ experiences in Canada

The complementary feeding period, defined as the introduction of solid foods alongside continued breastmilk and/or infant formula, is increasingly recognized as a critical window of opportunity for the healthy development of children. However, parental adherence to complementary...

Contribution of Adolescent Movement Behaviours to Socioeconomic Inequalities in Adult Cardiovascular Disease Risk: A Causal Decomposition in a Population-Based Cohort

Abstract Addressing unhealthy movement behaviours in adolescence could reduce socioeconomic inequalities in adult cardiovascular disease (CVD) risk. Among 6608 adolescents enrolled in the Add Health cohort (1994-1995) and followed into adulthood (2016-2018), movement behaviours (...

Proteomic profiling of the Pseudomonas aeruginosa stringent response highlights global adaptive responses during stationary phase

ABSTRACT Pseudomonas aeruginosa ( P.a ) is a clinically important opportunistic pathogen capable of adapting and surviving a wide range of environments and stress conditions. A central regulator of this adaptability is the stringent response, mediated by the alarmones (p)ppGpp. A...

What works in transdiagnostic adult psychiatric day treatment programs? A scoping review of common components contributing to improved mental health outcomes

Background Day Treatment Programs (DTPs) provide intensive, multidisciplinary, non-residential care for adults with acute or complex mental illness. Despite their long-standing role as recovery-oriented alternatives to inpatient admission, contemporary DTPs vary widely in structu...

From Awareness to Action: Co‐Designing Culturally Safe and Equitable Rehabilitation in Canada – Protocol for the Two‐Phase Ireach Qualitative Study

ABSTRACT Background Inequities in access, engagement, and outcomes persist across outpatient rehabilitation services in Canada, disproportionately affecting Indigenous Peoples, newcomers and refugees, gender‐ and sexually‐diverse individuals, and people with lower income. Althoug...

Respiratory Syncytial Virus–Related Hospitalizations Among Infants Receiving Nirsevimab

Importance Respiratory syncytial virus (RSV) is a leading cause of hospitalization among infants. Nirsevimab, a long-acting monoclonal antibody that protects against severe RSV, was publicly funded for all infants in the Canadian provinces of Ontario and Quebec starting in the fa...

SPEF1 mediates assembly of central pair microtubule complexes in cilia of Tetrahymena

SPEF1 is a conserved calponin-homology domain protein that decorates the seam of central pair microtubules in the distal segment of motile cilia. Here, we show that in the ciliate Tetrahymena, loss of SPEF1 disrupts the central pair throughout the middle segment, which comprises...

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

OBJECTIVE: We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. METHODS: We enrolled patients within 3 months of JIA diagnosis in th...

Sex & Gender Science: integrating the social with the biological

Abstract For decades, researchers have largely studied aspects of sex and gender separately; the former as a basic science and the latter as a social construct with real world consequences, including health inequities. In recent years, as our collective understanding of how the b...

Conference Goals And Learning Preferences Among Attendees at A National Surgical Meeting

Objective This study evaluated differences in conference goals and preferred learning modalities across demographic groups at a national surgical conference. Design An optional online survey collected demographic information (gender, practice type, role, years in independent prac...

Balancing data quality and participant burden: a comparative analysis of abbreviated vs extended symptom diaries in the CanTreatCOVID trial

Abstract Background Symptom diaries are widely used in acute respiratory infection trials to capture patient-reported symptom severity and recovery. Longer questionnaires may provide a more complete clinical picture but can increase participant burden and reduce adherence. Eviden...

GLP-1 Receptor Agonists and Musculoskeletal Outcomes: A Systematic Literature Review and Meta-Analysis

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly used for the treatment of type 2 diabetes and obesity, but their effects on musculoskeletal health remain completely misunderstood. This systematic review/meta-analysis aims to synthesise clinical data on the...

Diagnostic yield of repeat CT pulmonary angiography after a negative examination in the emergency department

PURPOSE: Although repeat CT pulmonary angiography (CTPA) after a negative index examination in the emergency department (ED) is common, its diagnostic utility remains uncertain. This study aimed to determine the incidence and diagnostic yield of repeat CTPA after a negative index...

Cefepime and Mortality

Importance Cefepime is recommended for the treatment of febrile neutropenia and gram-negative infections at moderate risk of ampicillin resistance locus C β-lactamase production. Concerns regarding cefepime’s safety have been raised in the literature without firm conclusions. Obj...

Motivation of Hospital Pharmacists Regarding the Transfer of Knowledge in Geriatrics (MOTIVPHARM-G)

Background: To foster equity for vulnerable populations, hospital pharmacists should be motivated to acquire new knowledge in geriatrics. No tool specifically designed to assess their motivation in this area exists. Objectives: To assess the motivation of clinical pharmacists in...

Monoclonal antibodies inhibiting MMP-9 activity alleviate peripheral neuropathy in diabetic mice

Diabetic peripheral neuropathy (DPN) is a debilitating medical condition that affects millions of individuals, causing neuropathic pain and chronic wounds. Despite its substantial impact, there are currently no effective disease-modifying treatments available to prevent or revers...

BetaII-spectrin gaps and patches emerge from the patterned assembly of the actin/spectrin membrane skeleton in human motor neuron axons

The actin/spectrin membrane-associated periodic skeleton (MPS) is a cytoskeletal structure that supports axonal integrity and function. Lower spinal motor neurons (MNs) are characterized by exceptionally long axons and are particularly susceptible to degeneration in a wide range...

Antifibrotic therapy in patients with pleuroparenchymal fibroelastosis: a multicentric observational study

Pleuroparenchymal fibroelastosis (PPFE) is a rare interstitial lung disease characterized by upper-lobe predominant pleural and subpleural fibrosis and associated with poor prognosis. No evidence-based medical therapy is currently established, and lung transplantation remains the...

ATAD2 is a novel regulator of myogenesis and autophagy in skeletal muscles

Abstract The nuclear protein ATAD2 (ATPase family AAA domain containing 2) is a known positive regulator of cell proliferation in various cancer types. The expression and functional roles of ATAD2 in skeletal muscle cells are unknown. In this study, we used transient and stable k...

Biomimetic Hydrogels with Nucleus Pulposus-like Viscoelasticity and ECM Peptides for Discogenic Differentiation of Stem Cells

Abstract Intervertebral disc (IVD) degeneration is a leading cause of low back pain (LBP), primarily originating in the nucleus pulposus (NP). Regenerative strategies combining mesenchymal stem cells (MSCs) with biomaterials offer great potential for NP repair by replenishing cel...