Massachusetts Institute of Technology

Hybrid Benzimidazole–Imidazole Carbodicarbene Ligands Control Deep-Red Emission from Photostable Borenium Ions

Abstract Carbodicarbenes (CDCs) are exceptionally strong neutral ligands used in main-group chemistry. Their combined σ- and π-donor abilities stabilize highly electrophilic main-group element centers while allowing the frontier orbitals and photophysical properties of their comp...

Size and shape of fuzzy spheres from matrix/membrane correspondence

Abstract We study the size and shape statistics of ground state fuzzy spheres when projected onto the transverse plane, utilizing the regularized SU(N = 2) matrix model in D = (1 + 3)-dimensional spacetime. We show that they appear as ellipses, from matrix/membrane correspondence...

Reconstructing signaling histories of single cells via perturbation screens and transfer learning

Manipulating the signaling environment is an effective approach to alter cellular states for broad-ranging applications, from engineering tissues to treating diseases. Such manipulation requires knowing the signaling states and histories of the cells in situ , for which high-thro...

Mutation E300 recommended by protein language models gives ChrimsonR amplified photocurrent response

Abstract A central challenge in opsin engineering is identifying mutations that reliably improve desired functional properties, a task made difficult by the enormous mutation space and limited throughput of electrophysiological screening. Improving opsin properties such as photoc...

The largest 5th pivot may be the root of a 61st degree polynomial

Abstract This paper introduces a number of new techniques in the study of the famous question from numerical linear algebra: what is the largest possible growth factor when performing Gaussian elimination with complete pivoting? This question is highly complex, due to a complicat...

Designing multi‐site studies for external validity: Site selection via synthetic purposive sampling

Abstract Multi‐site/context studies have become popular strategies to address the most common and challenging external validity concerns about contexts. Under such studies, scholars conduct causal studies in each site and evaluate whether findings generalize across sites. Despite...

Annual wake impacts in and between wind farm clusters – Part 1: WRF-simulated wake losses for different atmospheric conditions

Abstract. With the rapid increase in wind farm developments, it is essential to evaluate the impacts of newly constructed wind farms on adjacent wind farms, both existing and planned. Numerical weather prediction models are essential tools to predict wake effects, especially unde...

Colloidal and lithographic polymer templated nanostructures for chemiresistive gas sensors and intelligent gas discrimination

Metal-oxide-semiconductor (MOS)-based chemiresistive gas sensors are promising for real-time detection, but poor gas accessibility, stochastic charge transport, low selectivity, and high thermal burdens hinder their practical translation. Polymer templating provides a powerful ar...

Artificial intelligence for Amazonian health: validation is the price of entry

At the AI as Catalyst meeting in Manaus (July 28–29, 2026; https://ia-como-catalisadora-manaus.netlify.app), participants ran a simple exercise. Working in teams, they wrote about ten clinical cases and put each one to widely used general-purpose chatbots twice: first in standard...

Nuclear Localization Signals Enable the Cellular Delivery of an Anti-CRISPR Protein to Control Genome Editing

ABSTRACT Precise regulation of Cas9 activity is essential to minimize off-target effects, mosaicism, chromosomal alterations, immunogenicity, and genotoxicity in genome editing. Although type II anti-CRISPR proteins (Acrs) can inhibit and regulate Cas9, their size and anionic cha...

A comparison of passive and quasi-passive prosthetic ankles over varying speeds and terrains

Quasi-passive (QP) prosthetic ankle-foot devices can provide functional benefits over passive prostheses without the complexity, weight, and cost of fully powered devices. However, research examining how to best design QP ankles to optimize patient outcomes is limited. This rando...

Les Houches study on inclusive jet production at NNLO+NNLL

Jet production at the LHC is a powerful probe of QCD, making it ideal for precision tests and determinations of QCD parameters such as parton distribution functions and the strong coupling constant. To make the most of the abundant jet production data collected at the LHC, precis...

Peptides adopt stable omega-loop structures in concentrated sulfuric acid

The search for life beyond Earth has focused on planets and moons with liquid water, reflecting the assumption that complex biomolecules require aqueous environments to remain stable and functional. Such a view excludes a wide class of planetary settings, including the concentrat...

Time-of-Use Pricing Enhances Vehicle-to-Grid Benefits for Power Systems and Vehicle Owners but May Undermine Decarbonization

Abstract Vehicle-to-grid (V2G) is an important flexibility management technology for lower-carbon transport and the electricity grid. However, its effectiveness relies on the temporal alignment between the price incentives and grid dynamics. To overcome the challenge of coordinat...

Shuffle Tableaux, Littlewood–Richardson Coefficients, and Schur Log-Concavity

We give a new formula for the Littlewood–Richardson coefficients in terms of peelable tableaux compatible with shuffle tableaux, in the same fashion as Remmel–Whitney rule. This gives an efficient way to compute generalized Littlewood–Richardson coefficients for Temperley–Lieb im...

Organelle scaling over a 100-fold cell size range

ABSTRACT Cell size in a proliferating cell population generally varies over a limited range (∼2-4-fold). Within such populations, organelle content increases with cell size maintaining a relatively constant organelle density (amount per cell volume). However, cells of different t...

Magnetic-field-tunable cyclotron hyperbolic polaritons

Hyperbolic polaritons are conventionally associated with structural anisotropy or phononic Reststrahlen bands. Here, we predict a class of hyperbolic polaritons arising from magnetic-field-induced cyclotron motion of charge carriers. When a perpendicular magnetic field is applied...

Quantum-well metasurface for free-space-accessible enhanced nonlinear polarization

Abstract Nonlinear frequency conversion underpins important technologies such as telecommunications and quantum computation; however, weak nonlinearities and architectures that resist miniaturization currently limit devices’ efficiency and widespread adoption. Here we combine a b...

Suppressing phosphatidylserine externalization overcomes cancer immune evasion and enhances immunotherapy

Abstract Immune checkpoint blockade (ICB) has transformed cancer therapy, yet many tumors remain refractory to treatment due to diverse immune evasion mechanisms. To uncover novel drivers of ICB resistance, we performed an in vivo CRISPR-Cas9 screen in mice with increasing levels...

Organelle partitioning in the multi-budding yeast Aureobasidium pullulans

Cellular organelle content is fairly constant within a given cell type. This is accomplished in part by ensuring equitable organelle partitioning during division. Much of our understanding of organelle inheritance has come from investigating cells that divide in half producing tw...