Massachusetts Institute of Technology

ElectrochemicallyDriven Sorbent-Mediated Recoveryof CO2 in Marine Inorganic Carbon Extraction Processes

Abstract The oceans act as a sink for atmospheric CO2, absorbing more than a quarter of global emissions annually. Technologies for marine inorganic carbon dioxide removal (mCDR) have recently gained attention as a means of leveraging this effect to reduce environmental CO2 conce...

Microneedle patch-based delivery of mRNA vaccines: opportunities for next-generation immunization

Abstract Recent advances in messenger RNA (mRNA) vaccine technologies have enabled rapid responses to emerging infectious diseases and accelerated translation from antigen design to clinical deployment; however, their widespread implementation remains constrained by formulation i...

Redistributed, Not Reduced: The Role of International Trade in Global Food Supply Sustainability

Global food systems must balance productivity with environmental sustainability amid climate change, geopolitical shocks, and unevenly distributed natural resources. This study introduces the Food Supply Sustainability Index (FSSI), a transparent, composite measure of the sustain...

Closed‐Loop Solid‐State Synthesis Planning for Materials Discovery With Large Language Models

Developing reliable synthesis routes for complex materials remains a major bottleneck in accelerating materials discovery. This study establishes a large language model-based framework for predicting and optimizing synthesis conditions directly from the literature data. Key synth...

Transmission diffuse EUV scattering by nanoscale Lamb waves in thin membranes

We report time-resolved diffuse extreme ultraviolet (EUV) scattering measurements of optically excited acoustic waves in thin Ti/SiN bilayers in transmission geometry. Following femtosecond optical excitation, the EUV diffuse scattering signal yields circular fringe patterns evol...

Adaptive Design Assurance Levels for AI-Based Avionics Systems A Framework for Certification and Continuous Assurance

Artificial intelligence (AI) is increasingly proposed for perception, prediction, decision support, and automation in civil aviation. However, machine-learning components are data-dependent, statistically characterized, and vulnerable to uncertainty and distribution shift, while...

Adaptive Design Assurance Levels for AI-Based Avionics Systems A Framework for Certification and Continuous Assurance

Artificial intelligence (AI) is increasingly proposed for perception, prediction, decision support, and automation in civil aviation. However, machine-learning components are data-dependent, statistically characterized, and vulnerable to uncertainty and distribution shift, while...

Total Synthesis of(+)-CC-1065

Abstract The spirocyclopropanyl cyclohexadienone alkaloids are among the most potent antitumor natural products yet discovered. The intriguing biological activity and unique structures of these alkaloids have made them attractive targets for total synthesis. Herein, we report an...

The postsynaptic scaffolding protein SAPAP3 shapes mitochondrial activity: the case of Huntington’s disease

Abstract Postsynaptic scaffolding protein SAP90/PSD95-associated protein 3 (SAPAP3) modulates cortico-striatal signalling and regulates the maintenance of synaptic structure. Notably, SAPAP3 defects have been reported in several human psychiatric disorders that share pathophysiol...

Fecal microbiome transplant in food allergy in humans and mice identifies a role for bile acid metabolites in oral tolerance

The gut microbiome has been implicated in the pathogenesis of food allergy (FA), prompting microbiome-focused interventions. We evaluated, in a phase 1 open-label trial (NCT02960074), the safety and efficacy of oral encapsulated fecal microbiome transplantation (FMT) in 15 adults...

A dependency map enhanced with next-generation 3D cancer models

Despite advances in precision oncology, effective personalized treatments are still lacking for most patients with cancer1. The Cancer Dependency Map (DepMap) accelerates this field by systematically identifying cancer vulnerabilities in diverse preclinical models. Data from over...

The Andorra Scenario Engine: A Data-Grounded Framework for Policy-Oriented National Development Planning

Planning long-term national development under uncertainty is difficult for small states, where indicators are fragmented, frequently revised, and span tightly coupled social, economic, and environmental domains. Scenario tools can support such decisions without committing to a si...

Emerging innovations in movement ecology to address planetary challenges

Abstract Movement ecology—the study of how and why animals move within their environments—stands to offer transformative insights into our rapidly changing world, with benefits for both nature and people. Here, we present the first global horizon scan for movement ecology, engagi...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...

Vertical Coherence Dominates Decadal Land Water Storage Change Despite Hydroclimatic Extremes and Groundwater Pumping

Abstract Whether surface and deeper water storage trends move in the same direction underpins assessments of freshwater availability. Theory predicts vertical coherence, yet it is untested globally and questioned under climate extremes and human management. Using depth‐sensitive...

Materials and Music: Selective Imperfection as a Generative Framework for Analysis, Creativity and Discovery

ABSTRACT We introduce materiomusic as a generative framework linking the hierarchical structures of matter with the compositional logic of music. Across proteins, spider webs, and fluid or flame dynamics, vibrational and architectural principles recur as tonal hierarchies, harmon...

Late Ordovician ostracods from the “butter shale” Lagerstätten of the Cincinnati Arch region, Ohio, USA

Abstract The “butter shale” Lagerstätten of the Cincinnati Arch region is renowned for its well-preserved fossil records, documenting the dynamics of the Late Ordovician “Richmondian Invasion,” during which faunal migration from multiple source basins into the region led to a dra...

Intact Visual Correlation Detection in Autistic Adults

The ability to detect recurring temporal co-occurrence, or temporal correlation, of sensory events is fundamental for organizing perceptual input into coherent representations. Although past work has revealed differences across several aspects of temporal processing in autism, it...

Linker Symmetry Lowering as a Strategy to Tune Electronic Properties in Two‐Dimensional Conductive MOFs

ABSTRACT Two‐dimensional conductive metal–organic frameworks (2D cMOFs) have largely relied on highly symmetric linkers that give rise to symmetry‐protected electronic degeneracies. Although such symmetry usually promotes extended conjugation and often leads to high electrical co...

Cost‐Effectiveness of Radiofrequency Ablation for Benign Non‐Functioning Thyroid Nodules: A Systematic Review

ABSTRACT Purpose This systematic review tests the hypothesis that radiofrequency ablation (RFA) for benign non‐functioning thyroid nodules is associated with favourable cost‐effectiveness compared with surgery. Materials and Methods A systematic literature search of multiple data...