Manipal Academy of Higher Education

Urinary metabolomic signatures associated with left ventricular hypertrophy in chronic kidney disease: an exploratory gas chromatography-mass spectrometry study

Abstract Although left ventricular hypertrophy (LVH) is common in people with chronic kidney disease (CKD); its mechanisms are not well understood. Metabolomic profiling may reveal novel mechanistic pathways linked to cardiac remodelling in CKD patients. In this single-centre cro...

Hybrid CNN-GRU framework for wind turbine blade defect classification and data-driven severity assessment for predictive maintenance

Abstract The integrity of wind turbine blades is essential for the continuous production of renewable energy. If left unchecked, surface pollution and fissures hasten structural deterioration, lower aerodynamic efficiency, and result in catastrophic blade failure with serious saf...

CrayStack ensemble machine learning for predicting engine performance and emissions of multiple feedstock biodiesel blends with CaO-Al2O3 nanoparticles

Abstract The global transition toward sustainable energy has positioned multi-oil feedstocks (Garcinia gummi-gutta and Garcinia indica) to increase feedstock availability, which is vital to biodiesel production, thereby reducing fossil fuel dependencies and limiting harmful emiss...

Comparison of Ultrasound versus Combined Peripheral Nerve Stimulator Plus Ultrasound-guided Supraclavicular Blocks of Brachial Plexus for Upper Limb Surgeries

Abstract Background: Ultrasound (USG)-guided supraclavicular blocks are an asset in the realm of regional anaesthesia. Newer approaches, such as USG plus peripheral nerve stimulator (PNS), have often been indicated for better outcomes. Aim: The aim of the study was to compare USG...

Metacognitive team-based learning for creative problem-solving in Indian medical undergraduates: a single-arm pre-post quasi-experimental mixed-methods study

Abstract Background Metacognitive and team-based strategies can strengthen problem-solving; however, many Indian medical undergraduates remain reliant on rote memorisation with limited exposure to structured, creativity-focused pedagogy. Structured interventions combining metacog...

A wideband high-isolation four-port MIMO antenna with orthogonal diversity and DGS for 5G sub-6 GHz applications

Abstract The 5G NR sub-6 GHz bands n77 (3.3–4.2 GHz) and n78 (3.3–3.8 GHz) are widely used for modern 5G communication systems due to their balanced coverage and capacity. This work presents a compact wideband four-port MIMO antenna employing orthogonal diversity and defected gro...

Design and development of 5-aminoindan-based chemosensor for Hg2+ detection and cytotoxicity evaluation

Abstract Novel 5-aminoindan-based azo derivatives (3a–e) containing an indane moiety were designed and synthesized via diazotization and coupling reactions. The synthesized compounds were characterized by UV–Vis, FT-IR, 1 H NMR, and LC–MS spectral studies. Their electronic proper...

Clinicopathological characteristics, diagnostic challenges, and systemic implications of metastatic tumors to the eyelid: a systematic review

Abstract Background Metastatic tumors to the eyelid are rare but clinically significant, often indicating advanced systemic malignancy or presenting as the first sign of an occult primary. Histopathology is the diagnostic cornerstone, yet the spectrum of clinicopathological patte...

Agentic AI and consumer engagement in sustainable health and wellness tourism: reimagining service facilitation in digitalized ecosystems

Purpose The study explores agentic AI characterization on autonomy, adaptivity, empathy and transparency shaping sustainable consumer engagement within health and wellness tourism. Further, it aims to understand the mechanisms of AI agency promoting long-term trust, empathy and s...

Effect of thermal exposure on the wear and phase stability of HVOF-deposited WC-17Co coatings

Wear-induced material loss is a major concern in industrial applications, driving the development of wear-resistant surface coatings. High-velocity oxy-fuel (HVOF) spraying is widely used to deposit coatings with high bond strength, low porosity, and improved wear resistance. Amo...

Design, development and enhanced efficacy of host-derived antiviral peptides to prevent herpes simplex virus type 1 infection

Abstract Herpes simplex virus (HSV) remains a pervasive global health concern and has the ability to challenge current therapeutic strategies because of its frequent recurrence and drug resistance. This research aimed to disrupt the critical interaction between the viral glycopro...

Histoplasmosis in India: a systematic review of reported cases

BACKGROUND: Histoplasmosis is a systemic fungal infection caused by Histoplasma capsulatum and is increasingly recognised in India, but its epidemiology, clinical spectrum, diagnosis, treatment, and outcomes remain poorly characterised. We conducted a systematic review of reporte...

Ultra-StableHybrid Supercapacitor Enabled by α-MoO3/GrapheneNanohybrids: From Scalable Synthesis to Real-WorldApplications

Abstract The increasing demand for efficient and sustainable energy storage has accelerated research into supercapacitors (SCs), which provide high power density and a long cycle life. However, their poor performance remains a major drawback. The layered structure and rich redox...

Is Influencer Marketing More than Persuasion? A SOR-Based Review of the Indian Consumer Mindset

Influencer marketing has emerged as a dominant communication strategy in India’s rapidly expanding digital marketplace, reshaping how brands engage with consumers across social media platforms. Despite growing scholarly attention, existing research remains fragmented across theme...

Development and Content Validation of an Exercise‐Based Framework for the Management of Lumbar Radiculopathy

BACKGROUND AND PURPOSE: Current guidelines for the management of lumbar radiculopathy recommend patient education, staying active, manual therapy, and nonsteroidal anti-inflammatory drugs (NSAIDs) as first-line treatments. Physiotherapy-specific interventions for low back pain th...

Machine learning-assisted fixed-bed column adsorption of chlorpyrifos using sustainable biomass-derived activated carbon

Abstract Chlorpyrifos pollution in aquatic streams has become a serious environmental concern due to its high toxicity and adverse effects on ecosystems and human health. In this study, continuous fixed-bed column adsorption of chlorpyrifos was studied using activated carbon synt...

Enhancing botnet attack detection using a hybrid deep learning model combining network flow and DNS query features with explainable AI for cybersecurity

Abstract The growing dependency on the Internet and the expanding demand for connectivity have led to an increasing threat of botnet-based cyberattacks. Botnets are networks of infected devices managed by a botmaster. The botnets can launch distributed denial of service (DDoS) at...

Synergetic Enhancement in Thermoelectric Performance via Localized Magnetic Moments and Lattice Softening

ABSTRACT Magnetism‐assisted transport is achieved in Mn‐containing SnSe magnetic nanocomposites, where superparamagnetic MnSe nanoprecipitates are introduced to modulate both carrier and phonon scattering. Transmission electron microscopy reveals well‐dispersed 5–10 nm MnSe inclu...

Medullary Carcinoma of the Colon: A Case Report

Colorectal cancer (CRC) is a significant global health burden. Medullary carcinoma (MC) of the colon is a rare histological subtype, accounting for less than 3% of CRCs and often associated with hereditary nonpolyposis colorectal cancer (HNPCC). It is characterized histologically...

Understanding the Link Between Toxic Leadership and Employee Well-being: The Interplay of Employee Turnover, Organizational commitment, Shift timing & Industry Sector

<ns5:p>Background This study deals with the issue of toxic leadership and employees’ well-being, its effect on employees’ turnover among various industry sectors in the United Arab Emirates (UAE) and to gauge the moderating effect of organizational commitment, shift timing, and i...