Manipal Academy of Higher Education

Precision gene editing in infant neuroblastoma: a review of nanoparticle: enabled CRISPR/Cas9 therapies

Infant neuroblastoma (NB), defined by diagnosis during the first year of life, represents a clinically heterogeneous disease spectrum ranging from localized tumours with favourable outcomes and a capacity for spontaneous regression, to high-risk metastatic disease requiring inten...

Gamified digital training tools for enhancing indirect vision skills in preclinical dental education: a randomized control trial

Abstract Background Preclinical dental training emphasizes indirect vision using mirrors for precision and ergonomics to prevent musculoskeletal disorders. Students often face challenges with suboptimal posture and extended procedure times. Digital gamified tools like mobile app...

Implementing gender-focused DEI initiatives in B2B sales: Navigating cultural forces and organizational resistance

Diversity, equity, and inclusion (DEI) has emerged as a strategic imperative in business-to-business markets. Yet, existing DEI implementation frameworks underplay the roles of frontline translation and organizational resistance. This omission is consequential in global sales con...

A review of dispersion mechanisms in graphene reinforced ABS nanocomposites for additive manufacturing

Abstract Due to the enhanced mechanical, thermal, electrical, and tribological performance graphene-reinforced Acrylonitrile Butadiene Styrene (ABS) nanocomposites have emerged as promising materials for fused deposition modeling (FDM). However, realizing these improvements remai...

Effectiveness of conservative interventions on pain and disability in degenerative cervical spine disease: a systematic review and meta-analysis of randomized controlled trials

Abstract Background Degenerative cervical spine disease (DCSD) is a major cause of neck pain and disability worldwide. Although conservative interventions are widely used as first-line management, their comparative effectiveness remains unclear. This systematic review and meta-an...

Micro-magneto-rotation effects in magnetohydrodynamic two-phase blood flow through a porous layered artery

This study investigates the effect of micro-magneto-rotation (MMR) on magnetohydrodynamic (MHD) two-phase blood flow through a porous layered artery using a four-layer analytical model. To account for the rheological characteristics of blood, the core region is modelled as a micr...

Effect of Synthesis Route on Phase Evolution and Microstructural Characteristics of a MoNbSiTiW Refractory High‐Entropy Alloy

Silicon‐containing refractory high‐entropy alloys (RHEAs) provide a promising platform for combining a refractory body‐centered cubic (BCC) matrix with thermally stable silicide phases. However, the effects of the processing route on phase evolution and elemental partitioning in...

N-linked glycoproteomic and proteomic characterization of esophageal squamous cell carcinoma cell lines

Esophageal squamous cell carcinoma (ESCC) is an aggressive disease with a low survival rate. While considerable progress has been made in uncovering the biological mechanisms of the disease, diagnosing ESCC at an early stage remains challenging. Altered N-glycosylation patterns a...

Optical Dispersion and Dielectric Analysis of Sputtered Cr 2 O 3 Thin Films for Optoelectronic Applications

Chromium oxide thin films were deposited by DC magnetron sputtering under varying oxygen flow rates (14%–24%). This study evaluates the properties of both the as‐deposited and the post‐annealed samples. X‐ray diffraction (XRD) confirms the evolution from amorphous to crystalline...

A QMIX-driven routing protocol for dynamic Underwater Acoustic Sensor Networks

Abstract Reliable and energy-efficient data collection remains a fundamental challenge in Underwater Acoustic Sensor Networks (UASNs) owing to limited battery capacity, high propagation delay, dynamic network topology and unreliable communication links. To address these challenge...

Radiocarbon in dissolved inorganic carbon in unsaturated zone soil water of semi-arid western India

Abstract Estimating groundwater age is vital for water management, especially in semi-arid regions, where aquifers are the primary freshwater source. Radiocarbon ( 14 C) dating of dissolved inorganic carbon (DIC) is widely used to estimate groundwater age, assuming DIC is derived...

Orbiting towards myopathy: new paradigms of muscle atrophy in spaceflight

Abstract Protracted exposure to microgravity during spaceflight imposes stress on the human body which disrupts physiological homeostasis. Skeletal muscles are among the most severely affected, and they are characterized by rapid muscle atrophy. Although basal autophagy maintains...

Cognitive load and prefrontal neuromodulation shape exploration, risk-taking, and information seeking in experience-based decision making

Experience-based decision making requires individuals to balance exploration and exploitation under uncertainty, a balance that may be influenced by cognitive demands and prefrontal neuromodulation. We examined the joint effects of trivia-based cognitive load and anodal transcran...

Comparison of Bone Reduction Forceps and Elastic Traction for Symphysis and Parasymphysis Mandibular Fracture Reduction: A Prospective Non-Randomised Comparative Study

Abstract Background Symphysis and parasymphysis fractures are among the most common mandibular injuries and require accurate reduction before fixation. Traditional intermaxillary fixation (IMF) has several disadvantages, prompting interest in alternative reduction methods. This s...

Dual targeting of EGFR signaling and microtubule dynamics enhances replication-associated cellular stress and suppresses tumor growth in gefitinib-resistant non-small cell lung cancer

Acquired resistance to epidermal growth factor receptor (EGFR)-targeted therapy remains a major obstacle in the treatment of EGFR-mutant non-small cell lung cancer (NSCLC). This study investigated whether repurposing mebendazole (MBZ), a microtubule-disrupting agent, could restor...

Efficacy and Safety of Non-steroidal Versus Steroidal Immunosuppressants in Vitiligo Treatment: A Systematic Review and Meta-analysis

Vitiligo is an acquired chronic autoimmune depigmentation disorder, and mainstream treatment options for vitiligo are non-steroidal immunosuppressants/immunomodulators (NSIs) and steroidal immunosuppressants (SIs). However, there are variations in the efficacy and safety of NSIs...

Beyond Linear Paths: Configurations of Networks, Knowledge, and Dynamic Capabilities for Sustainable MSMEs

ABSTRACT Despite extensive research on entrepreneurial business networks (EBNs), knowledge management (KM), and dynamic capabilities (DC), three questions remain theoretically underdeveloped and empirically unexplored in resource‐constrained MSMEs. These concern the integrative m...

LTNE Analysis of Unsteady MHD Flow and Heat Transfer in an Expanding/Contracting Porous-Medium-Filled Pipe with Wall Injection/Suction

This study investigates magnetohydrodynamic (MHD) flow and heat transfer in a semi-infinite expanding or contracting porous pipe under local thermal non-equilibrium (LTNE) conditions with wall suction and injection. The governing momentum and energy equations for the fluid and so...

Performance Prediction and Analysis of Sweeping Gas Membrane Distillation Through Systematic Optimization of ANN Architectures

Sweeping gas membrane distillation (SGMD) is a thermally driven desalination process that uses a membrane to remove salts from seawater, achieving high salt-rejection rates at relatively low operating temperatures. Considering the coupled nature of heat and mass transfer and the...

Same hospital, same price, different protection: out-of-pocket expenditure for emergency trauma under public insurance, private insurance and self-payment in India

Background Out-of-pocket expenditure (OOPE) finances 43.4% of total health expenditure in India, and emergency trauma—unforeseeable, unpostponable and costly—is among the sharpest tests of whether a health-financing mechanism protects households from catastrophic spending. Insure...