Manipal Academy of Higher Education

Design, development and enhanced efficacy of host-derived antiviral peptides to prevent herpes simplex virus type 1 infection

Abstract Herpes simplex virus (HSV) remains a pervasive global health concern and has the ability to challenge current therapeutic strategies because of its frequent recurrence and drug resistance. This research aimed to disrupt the critical interaction between the viral glycopro...

Effect of thermal exposure on the wear and phase stability of HVOF-deposited WC-17Co coatings

Wear-induced material loss is a major concern in industrial applications, driving the development of wear-resistant surface coatings. High-velocity oxy-fuel (HVOF) spraying is widely used to deposit coatings with high bond strength, low porosity, and improved wear resistance. Amo...

Ultra-StableHybrid Supercapacitor Enabled by α-MoO3/GrapheneNanohybrids: From Scalable Synthesis to Real-WorldApplications

Abstract The increasing demand for efficient and sustainable energy storage has accelerated research into supercapacitors (SCs), which provide high power density and a long cycle life. However, their poor performance remains a major drawback. The layered structure and rich redox...

Histoplasmosis in India: a systematic review of reported cases

BACKGROUND: Histoplasmosis is a systemic fungal infection caused by Histoplasma capsulatum and is increasingly recognised in India, but its epidemiology, clinical spectrum, diagnosis, treatment, and outcomes remain poorly characterised. We conducted a systematic review of reporte...

Development and Content Validation of an Exercise‐Based Framework for the Management of Lumbar Radiculopathy

BACKGROUND AND PURPOSE: Current guidelines for the management of lumbar radiculopathy recommend patient education, staying active, manual therapy, and nonsteroidal anti-inflammatory drugs (NSAIDs) as first-line treatments. Physiotherapy-specific interventions for low back pain th...

Is Influencer Marketing More than Persuasion? A SOR-Based Review of the Indian Consumer Mindset

Influencer marketing has emerged as a dominant communication strategy in India’s rapidly expanding digital marketplace, reshaping how brands engage with consumers across social media platforms. Despite growing scholarly attention, existing research remains fragmented across theme...

Machine learning-assisted fixed-bed column adsorption of chlorpyrifos using sustainable biomass-derived activated carbon

Abstract Chlorpyrifos pollution in aquatic streams has become a serious environmental concern due to its high toxicity and adverse effects on ecosystems and human health. In this study, continuous fixed-bed column adsorption of chlorpyrifos was studied using activated carbon synt...

Enhancing botnet attack detection using a hybrid deep learning model combining network flow and DNS query features with explainable AI for cybersecurity

Abstract The growing dependency on the Internet and the expanding demand for connectivity have led to an increasing threat of botnet-based cyberattacks. Botnets are networks of infected devices managed by a botmaster. The botnets can launch distributed denial of service (DDoS) at...

Synergetic Enhancement in Thermoelectric Performance via Localized Magnetic Moments and Lattice Softening

ABSTRACT Magnetism‐assisted transport is achieved in Mn‐containing SnSe magnetic nanocomposites, where superparamagnetic MnSe nanoprecipitates are introduced to modulate both carrier and phonon scattering. Transmission electron microscopy reveals well‐dispersed 5–10 nm MnSe inclu...

A comprehensive review of deepfake generation methods, detection strategies and open challenges in multimedia and Internet of Things systems

Abstract Deep Learning (DL) has driven extensive progress in Artificial Intelligence (AI) and data analysis in areas such as communication and computer vision but this progress also increased misuse. A significant example is deepfake technology, which produces highly realistic fa...

Understanding the Link Between Toxic Leadership and Employee Well-being: The Interplay of Employee Turnover, Organizational commitment, Shift timing & Industry Sector

<ns5:p>Background This study deals with the issue of toxic leadership and employees’ well-being, its effect on employees’ turnover among various industry sectors in the United Arab Emirates (UAE) and to gauge the moderating effect of organizational commitment, shift timing, and i...

Fetal atrial strain: a scoping review of physiology, methods, and clinical applications

Abstract Background The evaluation of fetal cardiac function is moving towards the angle-independent myocardial deformation techniques, including the atrial strain obtained with speckle-tracking echocardiography. Angle-independent myocardial deformation techniques are gaining inc...

Medullary Carcinoma of the Colon: A Case Report

Colorectal cancer (CRC) is a significant global health burden. Medullary carcinoma (MC) of the colon is a rare histological subtype, accounting for less than 3% of CRCs and often associated with hereditary nonpolyposis colorectal cancer (HNPCC). It is characterized histologically...

Design and experimental validation of dual-feed cavity-backed slot antenna diplexer for millimeter-wave dual-band 5G applications

Abstract This article presents the development of a novel cavity-backed dual-feed miniaturized antenna with an intrinsic self-diplexing property for millimeter-wave dual-frequency 5G applications. The proposed device is designed using a rectangular substrate integrated cavity loa...

Bulk and single-cell multiomics insights into theca cell and granulosa cell dysfunction in polyendocrine metabolic ovarian syndrome

Abstract Polyendocrine metabolic ovarian syndrome (PMOS) is a heterogeneous disorder marked by a variety of clinical, hormonal, and metabolic disorders of an endocrine nature, affecting women of reproductive age and causing anovulatory infertility, metabolic dysfunction and hormo...

A comparative evaluation of deep learning architectures, loss functions, and ensemble strategies for underwater fish species classification

Abstract The accurate classification of underwater fish species is important for biodiver-sity monitoring, sustainable fisheries management, and aquaculture. However, underwater fish classification remains challenging due to class imbalance, varying imaging conditions, and high v...

Successful caesarean section under spinal anaesthesia in a pregnant woman with guillain–barré syndrome: a case report from a resource-limited setting

Guillain-Barre syndrome (GBS) is a rare but serious neurological condition due to autonomic instability, decreased respiratory function, and unpredictable medication responses, which can make pregnancy difficult and provide considerable anaesthetic issues. We report a case of a 2...

Translational design of multifunctional novasomes for theranostic-driven precision therapy of cutaneous oncology

Cutaneous oncology needs to be treated locally with maximal exposure to the target with minimum systemic toxicity. Novasomes, surfactant-rich vesicles, have proven to be promising theranostic carriers for both topical and intralesional delivery. This review aims to establish a tr...

Terminology for describing the 24-h cycle of physical activity, sedentary behaviour, and sleep: a scoping review

Abstract Background Physical activity, sedentary behaviour, and sleep are three behaviours which occupy the 24-h cycle and interact to influence a multitude of health outcomes. Different terms are currently used to describe these behaviours collectively (e.g., movement behaviours...

Association of small nerve fiber dysfunction on pain characteristics in type 2 diabetes mellitus individuals with chronic low back pain

Abstract Type 2 diabetes mellitus (T2DM) is associated with small nerve fiber (SNF) dysfunction. Quantitative assessment of thermal perception thresholds is a validated method for evaluating SNF dysfunction. Pain characteristics such as numbness and pain irritability are commonly...