Manipal Academy of Higher Education

Safety and efficacy of indigenous ultrathin-strut versus international thin-strut drug-eluting coronary stents in percutaneous coronary intervention: a systematic review of randomized controlled trials

Introduction Ultrathin-strut drug-eluting stents (DES) have been developed to enhance vascular healing and reduce restenosis following percutaneous coronary intervention (PCI). Indigenous biodegradable-polymer ultrathin-strut DES are increasingly used in high-burden settings; how...

Multicentre biobanking for rare diseases in India: Utility and challenges of lymphoblastoid cell line generation

Background and objectives For rare disease research, we aimed to establish immortalised lymphoblastoid cell lines (LCLs) from patient-derived blood samples. LCLs serve as a reliable substitute for accessing and studying the patient-specific disease biology, as patients may not al...

A deep learning-based plant disease classification using image recognition techniques

Abstract Plant diseases significantly threaten global food security, necessitating accurate and automated diagnostic systems. This work presents a modular deep learning framework for systematic benchmarking and comparative analysis of multiple architectures using the PlantVillage...

Optimized CNN–BiGRU–BiLSTM Architecture with Variational Mode Decomposition and Attention Mechanism for Electricity Price Forecasting

Abstract With the advent of deregulation in electricity markets, price forecasting has become an important task for generation and retail companies to enhance economic efficiency and market competitiveness. Traditional statistical models are widely employed, but they struggle to...

Burden assessment tools in epilepsy caregiving: A scoping review

Background Informal caregivers of people with epilepsy (PWE) experience a substantial burden because of the chronic nature and unpredictability of seizures. Although several caregiver burden assessment tools are available to quantify this burden, little is known about which of th...

Development and Validation of a Needs Assessment Guide for mHealth-Based Self-Management among Patients with Hypertension

Background Given the significant global burden of hypertension and the need to understand patients’ self-management needs, preferences, and barriers when developing mobile health (mHealth) interventions, this study aimed to develop and validate a Focus Group Discussion (FGD) guid...

Strategic Innovation in the Bakery Industry Through Underutilized Bioresources: A Narrative Review of Nutritional Enhancement, Circular Economy Approaches, Consumer Acceptance, and Industry 4.0 Technologies

The bakery industry is undergoing paradigm shifts due to increased customer demand for healthy foods, sustainable manufacturing techniques and innovations. At the same time, growing concerns about food waste, environmental harm and the depletion of natural resources are driving i...

Binary Mixtures of 4-acetylpyridine and 4-n-alkyloxybenzoic Acids (4Ac.Py:nOBA): Investigations on Mesomorphism

Abstract The induction and stability of mesomorphism in new binary mixtures capable of forming intermolecular hydrogen-bonding (HB) interactions were investigated. The mixtures were prepared by treating 4-acetylpyridine, a nonmesogenic liquid, with mesogenic 4- n -alkyloxybenzoic...

Study of performance and combustion in ammonia-fueled CI engines via diesel simultaneous injection

Abstract Ammonia is a promising carbon-free hydrogen carrier with wide industrial availability; however, its low flame speed, high latent heat, and narrow flammability characteristics create significant challenges for compression ignition engines. This study investigates ammonia/...

A review on intranasal nanoparticle delivery systems for blood–brain barrier penetration in medulloblastoma therapeutics: current insights and future perspectives

Accounting for approximately 20% of all childhood central nervous system (CNS) malignancies, medulloblastoma is the most common malignant pediatric brain tumor. Current standard-of-care treatment, comprising craniospinal irradiation, adjuvant chemotherapy, and surgical resection...

Surrogate-Driven Multi-Objective SMEPO Framework for Optimal EEG Channel and Feature Selection in Motor Imagery BCI

Abstract Brain-computer interfaces (BCIs) hold significant potential in communication, mechatronic control, and rehabilitation. However, existing BCI systems are often expensive, and require laborious preparation. A major challenge in motor imagery (MI)-based BCIs is the effectiv...

Effect of Sagittal Imbalance on Functional Disability in Patients with Degenerative Spondylolisthesis

BACKGROUND: Sagittal imbalance often causes pain and disability in patients with degenerative spondylolisthesis (DS). This occurs due to the slipping of one vertebra over another as a result of degenerative changes in the disc and facet joints. In this study, we aimed to assess t...

Inflectional Morphology Development and Its Association With Parental Input: Evidence From Kannada-Speaking Preschool Children

Morphological development is a crucial component of early language acquisition. This study examined developmental changes in types and tokens of inflectional morphemes produced among 214 typically developing Kannada-speaking preschool children and their parents. Inflectional use...

Delivery room skin-to-skin contact for preterm neonates: a systematic review and meta-analysis

Abstract Background Immediate skin-to-skin contact (SSC) is the biological norm for newborns; however, preterm infants are routinely separated from their mothers at birth because of fears of thermal and clinical instability. This practice prioritizes technical stabilization and p...

TiO2/PdO-based eye-detectable fast-responding sensor to address H2 safety infrastructure: Unveiling the colour change mechanism and active sites

Deployment of hydrogen-based infrastructure is impeded by the difficulty of real-time detection of hydrogen leaks. To address this issue, a TiO 2 /PdO composite chemochromic hydrogen sensor is optimized by tuning TiO 2 particle size and Pd precursor concentration to achieve rapid...

Mathematical analysis of electromagnetically driven squeezing flow in confined microchannels

Abstract Nanofluids flowing through confined channels are widely used in micro-cooling systems, miniature pumps, and other microfluidic technologies, where the combined effects of electromagnetic forces and variable fluid properties play an important role in transport phenomena....

Artificial Intelligence for MRI-Based Identification of Autism Spectrum Disorder: A Systematic Review of Methods, Performance, and Clinical Translation

Background Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by impairments in social communication and restricted or repetitive behaviours. Early diagnosis is important for timely intervention, motivating increasing interest in computer-aided diagnos...

Entrepreneurial Orientation and Sustainable Enterprise Growth: The Role of Entrepreneurial Agility

ABSTRACT This study examines the relationships among entrepreneurial orientation (EO), entrepreneurial agility (EA), and sustainable enterprise growth (SEG) in manufacturing SMEs in Ghana, drawing on Dynamic Capability Theory. A quantitative design was used, with data collected f...

Multi-objective sustainable DER allocation in active distribution networks based on Slime Mould Algorithm

Abstract The rapid increase in deployment of Distributed Energy Resources (DERs) is transforming traditional passive distribution networks into active and intelligent power systems capable of meeting the objectives of the sustainable energy transition. However, identifying approp...

Epigenetic modulators of melanogenesis: the role of environment, lifestyle, and stress

Abstract Melanogenesis is the process through which a pigment called melanin is produced by melanocytes in melanosomes. Increased or decreased production of melanin through melanogenesis can lead to pigmentation diseases, namely, hyperpigmentation and hypopigmentation. Melanogene...