Lanzhou University

Gas-Phase Detonation Synthesis of Defect-Rich Nanographitic Carbon for Lightweight Microwave Absorption

Abstract Scalable preparation of lightweight dielectric absorbers is critical for electromagnetic-interference mitigation; however, many high-performance carbon absorbers require multistep syntheses or high filler loadings that compromise processability and impedance matching. He...

Precise Nanoscale Mapping of Electric Fields Across Random Grain Boundaries in Polycrystalline Oxides Using Precession‐Assisted 4D‐STEM

ABSTRACT Space charge layers (SCLs) at grain boundaries play a crucial role in modulating electric fields and thereby influence functional properties of materials. However, experimental analysis of these localized electric fields and the corresponding charge distribution remains...

Thermodynamic Drivers of Rapid Transition From Drought to Flood in Siberia, Russia

Abstract Siberia is a warming hotspot under the impact of climate change, and faces growing threats from hydroclimatic extremes. The rapid transition from drought to extreme wet conditions (hereafter RTDFs) could exacerbate compound hazards, as intense rainfall on drought‐weakene...

PediatricLiver score: a novel risk score for screening elevated liver stiffness in the pediatric population (CHESS2401)

Given the looming crisis of rapid increase in childhood obesity globally, chronic metabolic diseases have consequently emerged but without sufficient awareness among children. Reliable and accessible screening tools thus are required to screen for significant liver fibrosis in th...

Targeted versus metagenomic next-generation sequencing in lower respiratory tract infection: complementary instruments and the interpretation problem that now limits clinical value

Objectives. To establish how targeted (tNGS) and metagenomic (mNGS) next-generation sequencing differ in analytical and diagnostic performance in lower respiratory tract infection (LRTI), how much of any difference is a property of the individual panel rather than of the platform...

Design, Synthesis, and Biological Evaluation of Novel, Fluorinated Camptothecin Derivatives as Potential Topoisomerase I Inhibitors

Abstract Camptothecin (CPT), a classical topoisomerase I (TOP I) inhibitor, shows potent antitumor activity but is limited by toxicity and lactone instability. Herein, structural optimization of the CPT scaffold was conducted via A-ring fluorination and C-7 and C-17 modifications...

Photo-Induced Three-Component Radical Trifluoromethylation/Heteroarylation of Alkenes via EDA Complexes

Abstract This study develops a visible-light-induced electron donor–acceptor (EDA) complex strategy, employing the inexpensive and readily available DBU as the electron donor and the industrially available CF3Br as the trifluoromethyl source, to achieve the trifluoromethylation/h...

Applied current induced degradation of delamination strength of coated conductors and microscopic mechanism revelation

Abstract Coated conductors in superconducting coils experience transverse stresses caused by thermal stress and large electromechanical forces during operation, which risk the coated conductors’ delamination due to their multilayer structure. However, the mechanical–electrical co...

Heterogeneity in cancer: molecular mechanisms and therapeutic strategies

Cancer heterogeneity drives therapeutic failure, resistance, and relapse and encompasses variation across genetic, cellular, tissue, organ, and systemic scales. Existing frameworks define malignant capabilities and tumor–microenvironment interactions but less explicitly address h...

Multi-view stereo and planar Gaussian splatting for generalizable surface reconstruction

Image-based three-dimensional (3D) reconstruction and novel view synthesis (NVS) play a critical role in applications such as virtual/augmented reality, 3D content generation, and autonomous driving. Recent studies have explored the integration of multi-view stereo (MVS) priors w...

Tyrosinase-Catalyzed Tyr–Aniline Coupling Enables Peptide Editing, Macrocyclization, and Phage-Display-Based Selection

Abstract Tyrosine-selective peptide modification provides a valuable route to late-stage diversification, yet current methods remain largely limited to site-specific labeling and rarely extend to macrocyclization or ligand discovery within a unified platform. Here, we report a ty...

Miocene northward expansion of the NE Tibetan Plateau via intracrustal underthrusting: insight from Cenozoic stratigraphy and provenance studies

The India–Eurasia collision and continued convergence caused significant uplift of the Tibetan Plateau and intracontinental deformation. However, how this convergence was accommodated at plateau margins remains debated, with two main models proposed: pure-shear thickening versus...

Rethinking ovarian cancer early detection: risk-adapted strategies, diagnostic pathways, and emerging biomarkers

Ovarian cancer early detection remains a major challenge because most patients present with advanced disease, whereas population-wide screening in average-risk women has not shown a clear mortality benefit. This narrative review examines how early detection should be redefined in...

Gilteritinib Suppresses Hepatocellular Carcinoma Cells in Association with Reduced Calpain-1 Expression and Inhibition of STAT3/AKT Signaling

Background/Objectives: Hepatocellular carcinoma (HCC) is a leading cause of cancer-associated mortality worldwide, and current targeted therapeutic options remain inadequate. Gilteritinib, a clinically approved tyrosine kinase inhibitor, has shown antitumor activity in hematologi...

Contagious caprine pleuropneumonia: a review and gap analysis of its impact, epidemiology, pathogenesis, and control

Contagious caprine pleuropneumonia (CCPP), caused by Mycoplasma capricolum subsp. capripneumoniae ( Mccp ), remains one of the most important small ruminant diseases and a major transboundary disease. Although primarily affecting goats, infections have also been reported in sheep...

Early Eocene Compressional Deformation in the Northeastern Tibetan Plateau Recorded by Magnetic Fabrics of the Longzhong Basin

Abstract Intracontinental deformation records how early Eocene India–Asia collisional stress propagated into continental interiors. How rapidly compression reached the far field, and whether coeval Paleo‐Pacific slab dynamics contributed, remain debated. The Longzhong Basin, ∼1,9...

The application value of DR metal artifact reduction technology in total knee arthroplasty

Abstract Objective To evaluate the effect of the Digital Radiography (DR) metal artifact reduction (MAR) technology (Enhanced Visualization Processing Plus, EVP Plus) in improving image quality in total knee arthroplasty (TKA) patients and its clinical value. Methods This explora...

Paeoniflorin Attenuates Radiation-Induced Brain Injury Associated with Modulation of Microglial Polarization and ERK/MAPK Signaling

Abstract Background: Radiation-induced brain injury (RIBI) is a common side effect of cranial radiotherapy that severely impairs patients’ neurological function and quality of life. Currently, effective and safe remedies for RIBI remain limited. Paeoniflorin (PF), a key component...

Capturing Spatial Covariance for Efficient Multipolar Electrostatic Parameterization in DNA via Multioutput Learning

Abstract In DNA force field development, introducing high-rank atomic multipole moments (AMMs) to describe electron cloud anisotropy improves the accuracy of electrostatic energy calculations. However, high-rank AMMs have many components. Existing machine learning methods usually...

Semi-recumbent position for the prevention of ventilator-associated pneumonia in adults requiring mechanical ventilation

RATIONALE: Ventilator-associated pneumonia (VAP) is associated with increased mortality, hospital stay, and healthcare costs in critically ill patients. Although guidelines recommend a semi-recumbent position for VAP prevention, the evidence remains uncertain due to limitations i...