Lanzhou University

Single-cell transcriptomic analysis reveals seed cells and microenvironmental crosstalk in gastric cancer peritoneal metastasis

Abstract Peritoneal metastasis is the most frequent and lethal metastatic pattern in gastric cancer, yet the identity of metastatic seed cells and the accompanying microenvironmental remodeling remain poorly defined. Integrated single-cell RNA sequencing analysis of cells derived...

Greening thy neighbor: The impact of cross-border high-speed rail network positions on transboundary air pollution in China

Existing studies mainly examine the environmental effects of high-speed rail (HSR) at the regional level, with limited attention to administrative border areas where pollution externalities interact with jurisdictional fragmentation. This study introduces the concept of cross-bor...

Anisotropic magnetic damping and interface spin transport in fully epitaxial cubic Fe74V26/Pt heterostructure

The directional control of magnetic damping and interfacial spin transport has emerged as a promising yet challenging route toward anisotropic spintronic devices. In this work, we investigated the magnetic damping and spin-pumping effect of fully epitaxial Fe74V26/Pt heterostruct...

Photoelectrocatalytic bromolactonization with NaBr as the bromine source coupled with hydrogen evolution

We report a mild and efficient photoelectrochemical (PEC) synthetic strategy for the construction of isobenzofuranone skeletons via bromolactonization using NaBr as the bromine source. This transformation proceeds in the absence of exogenous oxidants and additional catalysts, del...

Lower soil organic carbon mineralization and temperature sensitivity along a freeze-thaw erosion gradient in permafrost soils

Freeze-thaw erosion (FTE) is widespread in permafrost regions, yet its effects on soil organic carbon (SOC) dynamics remain unclear. Here, we investigated SOC fractions, physicochemical properties, microbial biomass and community composition, SOC-degradation functional genes, SOC...

Spatiotemporal characteristics of vegetation responses to compound drought and heatwave events in Central Asia

With climate warming intensifying, compound drought and heatwave (CDHW) events have become more frequent and intense in arid Central Asia, severely affecting vegetation growth. However, systematic quantitative assessments of vegetation responses and their drivers under such compo...

Surface and interface engineering of SnO2-based electron transport layers for high-performance and flexible perovskite solar cells

Perovskite solar cells (PSCs) have emerged as a leading photovoltaic (PV) technology, achieving rapid progress in power conversion efficiency (PCE) and promising prospects for scalable, flexible applications. Within these devices, the electron transport layer (ETL) plays a decisi...

Algorithms on partial inverse min–max spanning tree problem under the l∞-norm

Given a connected edge-weighted graph G and a forest F of G , the goal of the partial inverse min–max spanning tree problem is to change the weight function as little as possible, so that there is a min–max spanning tree with respect to the new weight function containing F . In t...

Inhibition mechanism of OH/F doping on radiation-induced optical degradation of amorphous silica

Irradiation-induced formation of color centers in amorphous silica often deteriorates the optical performance of the material, thereby significantly affecting its long-term service performance. At present, the mechanism underlying the inhibition of color centers induced optical p...

Histological significance of MPO, ER, and PR in endometrial polyps of premenopausal women.

BACKGROUND: Endometrial polyps (EP) can lead to irregular bleeding and infertility in women. The identification of biomarkers associated with EP holds clinical importance. METHODS: Patients who visited the hospital due to abnormal uterine bleeding, endometrial thickening, abnorma...

Spatial-homogenized soil-surface pollen data can service as substitute for lake-surface pollen assemblage

Lake-surface pollen assemblage is the ideal modern analogue for past climate and vegetation reconstructions quantitatively based on lacustrine fossil pollen spectra. Soil-surface pollen assemblage, on the other hand, has been more widely applied due to its ready accessibility, ye...

Digital communication and narrative governance in BRICS healthcare: a website media analysis of public hospital vision and mission statements

Abstract: This study conducts a qualitative thematic analysis of vision and mission statements from leading publicly listed hospitals in BRICS countries-Brazil, Russia, India, China, and South Africa-to explore institutional health priorities and strategic orientations. Drawing o...

Prevalence and geographic variation of enteric pathogens among asymptomatic individuals in China: a nationwide, cross-sectional, multiplex molecular survey

The increasing use of multiplex molecular assays has improved the detection of enteric pathogens, but baseline carriage in asymptomatic populations remains poorly characterized, complicating the interpretation of positive test results. We aimed to investigate the prevalence and g...

Microfluidic-based high-throughput isolation enhances the recovery of novel strains and diversity from Arctic soil microbiome

ABSTRACT Microbial cultivation remains essential for understanding the physiology, ecology, and biotechnological potential of environmental microbes, yet conventional plate-based methods (CPM) recover only a minute fraction of the environmental microbiome. Polar regions, particul...

Porcine Reproductive and Respiratory Syndrome Virus: Adaptive Immunity, Immune Evasion and Emerging Strategies for Disease Control

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important pathogens affecting the global swine industry. This review summarizes current knowledge of PRRSV-induced suppression of adaptive immune responses, with particular emphasis on imp...

Tidal Love numbers of multi-state Boson stars

Abstract In this paper, we calculate the tidal Love numbers of multi-state boson stars (MSBSs) composed of ground state and first excited state complex scalar fields. Under synchronized and nonsynchronized frequency conditions, the background solutions of MSBSs are classified int...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Trophic reorganization may contribute to shifts in nitrogen transformations following alleviation of saline alkaline stress

Soil salinization is a widespread form of land degradation, yet how saline-alkaline stress is linked to belowground micro-food webs and shapes nitrogen transformations remains poorly understood. Here we compare natural saline–sodic and reclaimed farmland soils in northeastern Chi...

Chronic Inflammation, Fibrotic Remodeling, and Regenerative Failure in Duchenne Muscular Dystrophy: Mechanisms and Therapeutic Opportunities

Duchenne muscular dystrophy (DMD) is an X-linked disorder initiated by dystrophin deficiency, but disease progression reflects more than sarcolemmal fragility. Recurrent myofiber injury sustains sterile inflammation through damage-associated innate immune signaling and downstream...

Modifications of Phenols with β-Lactam via Ring–Opening Reaction

Abstract We report a K2CO3-mediated modification of phenols via the ring-opening of β-lactams under mild conditions. This method is compatible with a broad range of substituted substrates, affording the corresponding amino acid-introducing phenolic products in good to excellent y...