Lanzhou University

Integrated multi-omics analyses reveal the role of PAXX in colorectal cancer progression and the tumor immune microenvironment

Abstract PAXX is a DNA double-strand break repair factor involved in classical non-homologous end joining. Although elevated PAXX expression has been reported in colon cancer, its functional role and downstream mechanisms in colorectal cancer (CRC) remain incompletely defined. Th...

Online fatigue performance evaluation method for smart CFRP-strengthened steel beam structures incorporating FBG monitoring information

Steel beams are susceptible to fatigue damage under long-term cyclic loading. Carbon fiber reinforced polymer (CFRP) strengthening technology has been widely adopted to improve the fatigue performance of steel beams due to its high strength-to-weight ratio, corrosion resistance,...

Association Between Air Pollution and Psoriasis-Related Outcomes: A Systematic Review and Meta-analysis

Skin diseases are a group of consequences due to exposure to air pollution that have received less attention. Among these diseases, the relationships between short-term and long-term exposure to air pollutants and psoriasis remain uncertain. The present systematic review and meta...

Directed construction of high-stability PtPd alloys for methanol electrooxidation

Direct methanol fuel cells (DMFCs) suffer from the high Nost, CO poisoning, and insufficient durability of Pt-based anodes. Alloying Pt with Pd offers a promising route to enhance CO tolerance, yet the stability of PtPd nanoparticles under operating conditions remains a critical...

Network analysis of illegitimate tasks, emotional labor, and turnover intention among clinical nurses: a cross-sectional study

The persistently high turnover rate of nurses worldwide continues to exacerbate workforce shortages, posing a significant threat to the stability of the nursing workforce and patient outcomes. Illegitimate tasks and emotional labor among nurses are key antecedents of their turnov...

Investigation of the transcription factor TEAD-based material basis of Astragalus synergistic dacarbazine in the treatment of uveal melanoma

Abstract Uveal melanoma (UM) is the most common intraocular malignancy in adults, and despite great advances in combination drug therapies based on UM-related pathways, targeted therapies remain an unmet medical need, and there has been a decrease in sensitivity to chemotherapy....

Atomic Engineering of Single Crystals: Designing High‐Efficiency Bifunctional Co/Fe Single‐Atom and Alloy Catalysts for Zinc‐Air and Zinc‐Ion Batteries

ABSTRACT Single‐crystalline metal oxides offer well‐defined coordination environments to suppress metal migration, yet their application as precursors for bifunctional oxygen electrocatalysis remains limited. In this study, single‐crystal x‐ray diffraction and Fourier‐transform i...

The gut microbiota of Brandt’s vole under varying population densities reveals contrasting patterns in the natural environment

The population density of rodents fluctuates due to intrinsic and extrinsic factors, inducing density-dependent effects on organisms and their habitats. The gut microbiota of herbivores plays a pivotal role in digestion, immunity, environmental adaptation, and host fitness. Crowd...

Diagnostic value of CEUS-VI-RADS for predicting muscle invasion in bladder cancer: Validation of the scoring system and introduction of tumor-bladder wall contact length as a supplementary quantitative metric

Purpose To validate the diagnostic performance of the Contrast-Enhanced Ultrasound-based Vesical Imaging-Reporting and Data System (CEUS-VI-RADS) and to explore the incremental value of the tumor-bladder wall contact length (TBCL) as a quantitative metric in predicting muscle inv...

Breaking Barriers Toward Practicality: Critical Materials and Strategies for High‐Energy‐Density Aqueous Zinc‐Ion Batteries

ABSTRACT Driven by the demands of grid‐scale energy storage and the electrification of transport, achieving superior energy density is pivotal to establishing a more sustainable and economically resilient battery ecosystem. However, aqueous zinc‐ion batteries (ZIBs), despite thei...

Phenyl- O -β- d -ribofuranoside Derivatives from the Plant Endophytic Fungus Neofusicoccum sp. LZUC-S1 and Their Herbicidal Activity

Abstract Seven novel phenyl-O-β-d-ribofuranoside derivatives (1–7), along with four known naphthalenones (8–11), were isolated from the endophytic fungus Neofusicoccum sp. LZUC-S1 using a bioactivity-guided isolation. Their chemical structures were elucidated through an integrate...

Human Umbilical Cord Mesenchymal Stem Cells Enhance Folliculogenesis and Fertility in Premature Ovarian Failure Mice via Regulating Steroid synthesis

Abstract Background Premature Ovarian Failure (POF) is a dysfunction that severely impacts women's physiological health and reproductive function. Human umbilical cord mesenchymal stem cell (hUCMSC) transplantation offers a promising therapeutic option for restoring ovarian funct...

Admission low-density lipoprotein cholesterol and early haematoma expansion after spontaneous intracerebral haemorrhage

Background The association between low-density lipoprotein cholesterol (LDL-C) and haematoma expansion (HE) after spontaneous intracerebral haemorrhage (ICH) remains uncertain. This study evaluated whether admission LDL-C was independently associated with early HE and whether it...

An online spectral nudging-based correction system: improving physical model forecasts by incorporating large-scale circulations derived from machine learning models

The development of traditional numerical weather prediction (NWP) relies on continuous advances in observation technology, data assimilation methods, numerical and parameterization algorithms, and the steady growth of computational resources, resulting in lengthy development cycl...

Integrating machine learning and data-driven modelling: predicting dengue outbreaks and revealing spatially heterogeneous climatic drivers in Brazil

Dengue fever poses a major global health threat, with Brazil experiencing severe recurrent outbreaks driven by climatic, socio-economic and mobility factors. Accurate prediction remains challenging owing to dynamically shifting transmission patterns under intervention. This study...

The performance of GaSb cell and coupling effect of thermal-optical-electrical in thermophotovoltaic system

Radioisotope thermophotovoltaic (RTPV) systems, with their inherent high energy density and conversion efficiency, represent a promising power solution for deep space exploration. Under the strict heat dissipation constraints of deep space missions, different optical cavity confi...

Social connections and risk of cardiovascular disease: a 25-year population-based cohort study

Abstract Background Although the associations of social isolation and loneliness with cardiovascular disease (CVD) risk have been extensively studied, evidence that simultaneously evaluates multiple dimensions of social connection remains limited. We aimed to examine the associat...

Topological Reinforcement of Rhizosphere Microbial Networks Facilitates the Invasive Superiority of Spartina anglica

Rhizosphere microbial interaction patterns underpin the resilience and dominance of invasive plants in fluctuating coastal salt marshes. We compared the rhizosphere microbial communities of the invasive Spartina anglica and the native Spartina maritima across varying distances fr...

Result-Oriented Generation Meets Process-Oriented Creation: Understanding the Tension Between Generative AI and Craft Practice

Generative artificial intelligence (GenAI) is reshaping creative work, yet research focuses mainly on digital creation, with limited attention to embodied practices grounded in material interaction and physical making. Taking craft as an entry point, we examine GenAI in craft thr...

Bisphenol A and Its Substitutes Bisphenol S/Bisphenol F in Combined Exposure Collectively Exacerbate Hepatotoxicity by Triggering Oxidative Stress and Inflammatory Responses via the PI3K-Akt/NF-κB Axis

Abstract Bisphenol A (BPA) and its substitutes bisphenol S (BPS) and bisphenol F (BPF) are environmental endocrine-disrupting chemicals that frequently co-occur. However, the hepatotoxic effects and underlying mechanisms of their combined exposure remain unclear. This study integ...