Kunming Medical University

Health inequalities in the global reproductive-age population: GBD 2021 trends and female-male differences, 1990–2021

Socioeconomic health inequality among reproductive-age populations remains insufficiently characterized globally. Using GBD 2021 data for individuals aged 15–49 years in 204 countries and territories, we assessed disability-adjusted life year (DALY) rates and quantified absolute...

Factors affecting the decline of intrinsic capacity of older adults in Chinese communities: a systematic review and meta-analysis

With the rapid aging of the global population, maintaining the intrinsic capacity of older adults has become a critical public health priority. However, the pooled prevalence of intrinsic capacity decline and its key determinants remain unclear. This study aims to assess the rate...

Data-driven clinical phenotypes of diabetic kidney disease and their association with disease progression: a real-world cohort study

Diabetic kidney disease (DKD) has a heterogeneous clinical course. A refined classification of DKD phenotypes could help identify patients at increased risk of kidney disease progression and guide individualized clinical management. This retrospective cohort included 6,667 adults...

Research progress on the diagnosis and treatment of far-out syndrome

Abstract Far-out syndrome (FOS) is a rare cause of L5 radiculopathy, resulting from extraforaminal compression of the L5 spinal nerve within the lumbosacral tunnel. The diagnosis requires the simultaneous fulfillment of two necessary conditions: compression located within this sp...

MMP-9–responsive stealth-to-activation liposomes enable tumor-selective PD-L1 degradation via dual-PEG shedding

Abstract PD-1/PD-L1 blockade benefits patients across > 20 cancer types, yet durable responses remain limited and antibody therapies only transiently engage the axis while causing systemic immune-related adverse events. We report lipoRDPA, a rationally designed liposomal degrader...

ANGPTL4 is a hypoxia associated candidate linked to immune and vascular phenotypes in ccRCC

Clear cell renal cell carcinoma (ccRCC) is characterized by prominent vascularization and cellular heterogeneity, but reliable biomarkers for angiogenesis and response to targeted therapy remain limited. In this study, transcriptomic data from GEO cohorts (GSE53757, GSE66271, GSE...

Measuring Ethical Perceptions of AI in Nursing: The Development and Validation of the AI‐Ren Ethics in Healthcare (RATI) Scale

AIM: To develop and validate a culturally sensitive instrument for assessing nurses' ethical perceptions of artificial intelligence in clinical practice. METHODS: A two-phase scale development study was conducted among nurses in China. The first phase involved item generation thr...

Huangqi Guizhi Wuwu Decoction Ameliorates Cachexia in Lung Cancer Mice Through Regulating Amino Acid Metabolism: Insights From Transcriptomics, Metabolomics and Experimental Validation

ABSTRACT The effects and mechanisms of Huangqi Guizhi Wuwu Decoction (HGWD) in cancer cachexia remain unclear. We generated an in vivo cachexia model by implanting Lewis lung carcinoma cells into mice and treated animals with HGWD. We evaluated muscle function using grip strength...

Stage-specific remodeling of the pulmonary microenvironment during Paragonimus proliferus infection in a rat model

Paragonimiasis, a food-borne zoonosis caused by Paragonimus spp., can cause severe pulmonary inflammation and fibrosis. However, relationships among the host, parasite and lung microbiome at defined infection stages remain poorly understood. We compared independent groups of rats...

Effectiveness of OBE-oriented and online-offline blended teaching versus traditional lecture-based teaching in nuclear medicine nursing education: a multicenter prospective comparative study

Nuclear medicine nursing demands high professional competence, particularly in radiation protection and radiopharmaceutical management. Traditional lecture-based teaching (LBT) fails to meet modern training needs. Outcome-Based Education (OBE) and online-offline blended teaching...

Sphingosine‐1‐Phosphate Attenuates LPS‐Induced Inflammatory Cardiac Injury in Association With RASGRP1–S100A9–NLRP3 Signaling

Lipopolysaccharide (LPS) induces endotoxemia-associated inflammatory cardiac injury rather than classical viral or autoimmune myocarditis. Sphingosine-1-phosphate (S1P) regulates cardiovascular and immune responses, predominantly through S1P receptors, but whether it also modulat...

Mitochondrial dysfunction drives metabolic reprogramming in Gitelman syndrome: insights from proteomics and isogenic modeling

Gitelman syndrome (GS) is an autosomal recessive tubulopathy caused by SLC12A3 gene mutations. While electrolyte disturbances are well-defined, the systemic metabolic consequences and underlying mechanisms remain unclear. This study investigated whether SLC12A3 mutation drives mi...

Density Gradient Centrifugation Versus Swim‐Up for Cumulative Live Birth in IVF/ICSI Cycles With High Sperm DNA Fragmentation: A Propensity Score Matching Analysis

BACKGROUND: A high sperm DNA fragmentation index (DFI) has been found to be associated with male infertility and suboptimal outcomes in assisted reproductive technology (ART). Although sperm preparation techniques can reduce DFI following processing, it is unclear whether density...

Global burden and influencing factors of gastrointestinal diseases: a systematic review and meta-analysis

Abstract Background/objective Gastrointestinal diseases are significant public health conditions affecting millions globally. This review aims to meta-analyzed the pooled prevalence estimates and influencing factors of gastrointestinal diseases. Materials/methods We systematicall...

Prevalence of diabetes, self-management behaviors, and their association with activities of daily living among older adults in rural southwest China

This study aimed to examine the prevalence of diabetes and impaired ADL in Yunnan residents aged 60 years and over, as well as detect associations between impaired ADL and self-management behavior. Further, to investigate diabetes diagnosis’ and self-management behaviors’ ability...

Current and future burden of gastric cancer: an analysis based on CDC WONDER and the global cancer observatory

Gastric cancer remains a major contributor to the global cancer burden, with marked geographic disparities and a substantial contribution from population ageing. We aimed to integrate recent mortality trends in the United States with the latest global burden estimates to provide...

A novel JAG1 variant causing familial Alagille syndrome

Alagille syndrome (ALGS) is a rare autosomal dominant multisystem disorder typically caused by pathogenic variants in JAG1 and NOTCH2, accompanied with a wide range of clinical variability. Currently, new pathogenic variants in JAG1 and NOTCH2 have been continuously reported. Exo...

Helicobacter pylori genotypes, virulence and antibiotic resistance patterns among outpatients with gastric diseases in representative urban-rural areas of Yunnan, China

Abstract Background The epidemiological and molecular characteristics of Helicobacter pylori ( H. pylori ) across different gastric lesion stages remain unclear. This study aimed to analyse H. pylori positivity, phylogenetic lineages, virulence genotypes, and antibiotic resistanc...

Ellagic Acid Enhances RSL3 ‐Induced Ferroptosis by Inhibiting the Nrf2/ HO ‐1 Signaling Pathway in Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) exhibits profound therapeutic resistance due to redox adaptation, particularly through Nrf2/HO-1 pathway activation. Ferroptosis induction via GPX4 inhibitors (e.g., RSL3) is promising but limited by adaptive antioxidant responses. Ellagic...

Ultrasound triggered microbubbles enhance the diagnosis and therapy of colorectal cancer

Abstract As an emerging integrated diagnostic and therapeutic platform, ultrasound-triggered microbubbles (UTMBs) have demonstrated significant potential in the treatment of colorectal cancer (CRC). This article introduces the different types of UTMBs, including micron-sized bubb...