Kunming Medical University

Interpretable Machine Learning for Predicting Radiation-Induced Hypothyroidism in Head and Neck Cancer: A Dual-Center Retrospective Study

Background/Objectives: Radiation-induced hypothyroidism (RIHT) is a frequent complication in head and neck cancer (HNC) patients following radiotherapy, significantly impacting quality of life. This study aimed to develop and validate an interpretable machine learning model for p...

Acupuncture alleviates the progression of lumbar disc herniation by regulating the autophagy level of nucleus pulposus cells through the SIRT1/Sestrin2 pathway.

BACKGROUND AND PURPOSE: Lumbar disc herniation (LDH) is a degenerative spine disease and the most common cause of lower back pain, with a high prevalence in younger patients. The use of acupuncture (AC) as a conservative treatment for LDH has received widespread attention at home...

Combined Hyaluronic Acid and Collagen Injections for Perioral Rejuvenation: A Randomized Controlled Trial

ABSTRACT Background The perioral region, a critical facial aesthetic subunit, undergoes age‐related changes addressed primarily through dermal fillers. Optimal rejuvenation requires tailored approaches integrating anatomical precision, filler physicochemical properties, and stand...

Nigral DJ-1 gene knockout in tree shrews can induce phosphorylated α-synuclein aggregation and all key phenotypes of Parkinson’s disease

Abstract DJ-1 is a genetic factor associated with Parkinson’s disease (PD), and altered DJ-1 function has been implicated in PD pathogenesis. However, DJ-1 knockout mice fail to reproduce robust PD-like phenotypes or neuropathology, leaving the contribution of DJ-1 deficiency to...

Alignment between undergraduate public health training and workforce competency requirements under medical–public health integration: a dual-perspective cross-sectional study in Yunnan, China

Misalignments may exist between undergraduate public health training and frontline workforce competency requirements under medical–public health integration, particularly in border and multi-ethnic regions. This study assessed this alignment from the combined perspectives of stud...

Sequential Integration of Microenvironment Regulation Utilizing Aggregation‐Induced Emission Luminogen‐Based Carbon Dots for Diabetic Wound Treatment

Effective management of diabetic wound healing remains challenging due to the complex wound microenvironment, characterized by persistent infections and inflammation, as well as obstacles in tissue repair, including impaired extracellular matrix (ECM) remodeling and re-epithelial...

Complete genome-derived metabolic interactions reveal the impact of gut ecology on human health

Abstract Metabolic interactions govern gut microbiome assembly, yet functional rules remain obscured by genomic incompleteness and fragmentation. Here, we leverage 1,150 complete genomes to construct genome-scale metabolic models, demonstrating that draft genomes introduce system...

Synergistic antitumor immune activation in melanoma using LA-PegPI polymeric gene vaccine in conjunction with PD-1 inhibition

Cancer gene vaccines are a promising avenue for cancer immunotherapy; however, their success depends not only on the gene construct itself but more critically on the efficacy and safety of the gene delivery vehicle. Targeting dendritic cells (DCs), the specialized antigen-present...

Integrated proteomics and metabolomics reveal how functional protein supplementation enhances salt tolerance in Zygosaccharomyces rouxii

Zygosaccharomyces rouxii is a halotolerant yeast widely associated with traditional high-salt food fermentations, while also being recognized as a spoilage microorganism in some food systems. Although its performance in fermented foods is strongly influenced by high salinity, the...

Exosomal lncRNAs in Cerebrovascular Diseases: Biomarkers, Pathological Mechanisms, and Therapeutic Potential

Background: Cerebrovascular diseases have complex pathogenesis and pose a serious threat to human health; thus, novel diagnostic and therapeutic strategies are needed. Small extracellular vesicles (sEVs), commonly referred to as exosomes, are 30–150 nm lipid-bilayer vesicles that...

Multimodal nanomedicine for precision colorectal cancer management: integrated diagnosis, targeted therapy, and personalized theranostics

Colorectal cancer (CRC) imposes a substantial health burden because of its high incidence and mortality. Despite advances in surgical procedures, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, the overall efficacy is still unsatisfactory, especially for advanced...

Salt-tolerant β-glucosidases from Karamay saline soil for soybean isoflavone bioconversion

β-Glucosidase (EC 3.2.1.21) hydrolyzes β-glycosidic bonds and is widely used in the food, fuel, and pharmaceutical industries. It holds significant potential particularly for converting glycosides, such as soybean isoflavone glycosides and ginsenosides, into their more bioactive...

Dietary Fatty Acids, Cardiovascular Disease, and Life Expectancy Among Adults With Adverse Mental Health‐Related Characteristics: A Cohort‐Based Target Trial Emulation Study

ABSTRACT Adverse mental health‐related characteristics contribute to decreased life expectancy, largely driven by an elevated risk of cardiovascular disease (CVD). Dietary fatty acids influence disease occurrence and progression, yet the associations of polyunsaturated fatty acid...

Exploration and practice of a DeepSeek‑enhanced, scenario‑based teaching model integrated with a multidisciplinary team approach in gastroenterology residency training

The first year of standardised residency training is a critical transition from medical student to clinical practitioner, during which trainees struggle to integrate theoretical knowledge with clinical competencies. Traditional teaching often lacks active learning and authentic c...

Tetrahydrocurcumin ameliorates depression-like behaviors in chronic restraint stress mice by modulating neuroinflammation and neurotrophic balance via the SIRT1/NF-κB pathway.

OBJECTIVES: the SIRT1/NF‑κB pathway. METHODS: experiment, BV2 microglial cells were stimulated with lipopolysaccharide (LPS) and treated with THC with or without the SIRT1 inhibitor EX-527 for validating the pathway mediating the effect of THC. RESULTS: cells and increased SIRT1...

Effect of Moringa oleifera Seeds Rennet on the Quality of Mozzarella Cheese and Proteomic Identification and Molecular Docking Analysis of Fermentation-Derived Peptides

Abstract This study aimed to characterize bioactive water-soluble peptides (WSPs) in Moringa oleifera seeds rennet-derived cheese (MSRC) and compare them with those in calf (CRC), papain (PRC), and microbial rennet cheese (MRC). Proteolysis of MSRC was enhanced, as indicated by i...

Identification of key genes related to phagocytic regulatory factors in nonalcoholic fatty liver disease: transcriptome and single cell combined analysis

Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease. Disturbed phagocytic regulation may affect lipid clearance, inflammatory balance, and cell-cell communication during disease progression, but phagocytosis regulatory factors (PRFs) in NAFLD have not been...

Machine learning-based analysis of behavioral and dental plaque microbiome features associated with dental caries in 5-year-old children from urban and rural Yunnan

This study aimed to integrate questionnaire-based oral health behavior data with dental plaque microbiome profiles to identify behavioral and microbiological factors associated with dental caries among 5-year-old children from urban and rural areas of Yunnan Province. It also eva...

Raw pyrite tailings as fine aggregate in mortar: performance and potential for architectural surface design

The accumulation of pyrite tailings (PT) poses severe environmental threats, yet its potential as a secondary resource for the construction sector remains underexplored. This study presents a preliminary investigation of raw PT as a partial substitute for fine aggregate in mortar...

From predictive model to clinical application: interpretable prediction of metachronous liver metastasis in colorectal cancer

Metachronous liver metastasis (MLM) after curative surgery is a major determinant of poor prognosis in colorectal cancer (CRC), yet existing approaches based on clinicopathological indicators or imaging alone have limited predictive performance and clinical applicability. This re...