Kunming Medical University

Ultrasound triggered microbubbles enhance the diagnosis and therapy of colorectal cancer

Abstract As an emerging integrated diagnostic and therapeutic platform, ultrasound-triggered microbubbles (UTMBs) have demonstrated significant potential in the treatment of colorectal cancer (CRC). This article introduces the different types of UTMBs, including micron-sized bubb...

Ellagic Acid Enhances RSL3 ‐Induced Ferroptosis by Inhibiting the Nrf2/ HO ‐1 Signaling Pathway in Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) exhibits profound therapeutic resistance due to redox adaptation, particularly through Nrf2/HO-1 pathway activation. Ferroptosis induction via GPX4 inhibitors (e.g., RSL3) is promising but limited by adaptive antioxidant responses. Ellagic...

Helicobacter pylori genotypes, virulence and antibiotic resistance patterns among outpatients with gastric diseases in representative urban-rural areas of Yunnan, China

Abstract Background The epidemiological and molecular characteristics of Helicobacter pylori ( H. pylori ) across different gastric lesion stages remain unclear. This study aimed to analyse H. pylori positivity, phylogenetic lineages, virulence genotypes, and antibiotic resistanc...

Dynamic association between gut microbiota succession and host metabolism: differential effects of antibiotic intervention duration on glucose and lipid metabolism in high-fat diet-induced obese mice

Abstract Background The gut microbiota plays a critical role in the onset and progression of obesity. Previous studies have indicated that antibiotic administration may influence host physiology and pathology by modulating the gut microbiota. However, whether different durations...

Noncanonical function of Claudin-1 mitigates lethal endoplasmic reticulum stress to drive prostate cancer lineage plasticity and chemoresistance

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (CRPC) driven by therapy-induced lineage plasticity. While endoplasmic reticulum (ER) homeostasis is critical for cell fate determination and therapeutic response, the molecular mech...

Development and validation of an exosomal microRNA prognostic signature for BCLC stage A/B hepatocellular carcinoma

Hepatocellular carcinoma (HCC) exhibits remarkable prognostic heterogeneity within identical Barcelona Clinic Liver Cancer (BCLC) stages, thus requiring more precise molecular biomarkers. Exosomal microRNAs (miRNAs) are stable, non-invasive biomarkers that faithfully reflect the...

Longitudinal associations between cardiovascular-kidney-metabolic stage and cognitive trajectories among middle-aged and older Chinese adults

Cardiovascular–kidney–metabolic (CKM) dysfunction and cognitive decline frequently coexist, but the temporal direction and potential biomarker pathways linking stage-based CKM burden to cognitive change remain uncertain. We analysed 5547 adults aged 45 years or older from the 201...

Comparative effectiveness and safety of robotic versus laparoscopic liver resection for benign liver diseases: a systematic review and meta-analysis

Robotic liver resection (RLR) is increasingly used as an alternative to laparoscopic liver resection (LLR), but its comparative effectiveness and safety for benign liver diseases remain uncertain. We performed a systematic review and meta-analysis to compare perioperative outcome...

Left ventricular end-diastolic diameter to body surface area ratio as a continuous risk marker in left ventricular non-compaction with a dilated phenotype: a multicenter cross-sectional study

Dilated cardiomyopathy (DCM) is a risk factor for poor outcomes in patients with left ventricular non-compaction (LVNC). This study aims to identify key factors associated with the DCM phenotype in LVNC and develop a risk stratification model. This multicenter cross-sectional stu...

Machine learning prediction of SIRS after percutaneous nephrolithotomy in older adults: role of frailty, malnutrition, and sarcopenia

Systemic inflammatory response syndrome (SIRS) after percutaneous nephrolithotomy (PCNL) is a critical complication in older adults. However, the impact of frailty, malnutrition, and sarcopenia (F-M-S) comorbidity on postoperative SIRS remains unclear. This study aimed to evaluat...

Factors influencing inhaled medication adherence among hospitalized patients with chronic obstructive pulmonary disease from rural and township areas of China with prior primary care experience: a mixed-methods study

Patients with chronic obstructive pulmonary disease require long-term medication to control their symptoms. This study explored factors influencing adherence to inhaled medications in hospitalized patients with chronic obstructive pulmonary disease who resided in rural and townsh...

Cannabis sativa L. juice as a novel functional drink ameliorates hyperlipidemia by inhibiting lipid synthesis and oxidative stress

Hyperlipidemia is a major public health concern due to its increasing global prevalence. Hemp seed ( Cannabis sativa L. seed) is a medicinal plant that has gained attention for its potential applications under the “homology of medicine and food” framework. Previous studies sugges...

Simultaneous Determination of Three Residual Monomers in Polyvinyl Alcohol Eye Drops Using a Dual‐Wavelength RP‐HPLC Method and Evaluation of Its Greenness

ABSTRACT Polyvinyl alcohol eye drops contain high‐molecular‐weight polymeric raw materials and excipients whose synthesis, storage, and pharmaceutical manufacturing processes may introduce or generate residual monomers, thereby affecting the quality, safety, and stability of the...

Seminiferous Tubules‐Targeted Resveratrol Carbon Dots With Sertoli Cell Biomimetic Vesicles Fusion for Improving Spermatogenesis of Cryptorchidism

ABSTRACT Impaired blood‐testis barrier (BTB) integrity, induced by oxidative stress, is one of the primary factors leading to spermatogenic disorders in cryptorchidism. Therefore, the targeted elimination of testicular oxidative stress and repair of the BTB are promising strategi...

Emotional and behavioral problems in children of parents with severe mental illness in Wuhan, China: the roles of child maltreatment and exposure to parental victimization

Guided by a developmental-ecological and trauma-informed framework, children of parents with severe mental illness (SMI) may develop emotional and behavioral problems (EBPs) through inherited vulnerability, disrupted caregiving, socioeconomic adversity, stigma, and trauma-related...

Mobile health interventions for oral health-related behavior management in adolescents with fixed orthodontic appliances: a scoping review

To map the characteristics of mobile health interventions for oral health-related behavior management among adolescents undergoing fixed orthodontic treatment, identify the behavior change techniques embedded within these interventions, and summarize the reported behavioral, clin...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Genomic and transcriptomic landscape of overweight Chinese breast cancer reveals NOTCH2 mutation–mediated endocrine resistance and therapeutic strategies

Abstract Background Obesity (OB) and overweight (OW) are common in patients with breast cancer and are associated with inferior outcomes, yet their impact on tumor molecular architecture remains incompletely understood. This study aimed to define the genomic and transcriptomic fe...

Universal Metal Electrode Contacts in Perovskite Solar Cells via Fermi‐Level Pinning at Yb‐Doped n + Fullerene Interfaces

ABSTRACT Efficient electron extraction at the electron transport layer (ETL)/metal interface is critical for high‐performance perovskite solar cells (PSCs), which is fundamentally governed by interfacial energy‐level alignment; however, the microscopic mechanism by which low‐resi...